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Phase I・II clinical trial of fusion vaccine combined with chemotherapy

Research Project

Project/Area Number 19591494
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTeikyo University

Principal Investigator

OKINAGA Kota  Teikyo University, 医学部, 教授 (00101098)

Co-Investigator(Kenkyū-buntansha) IINUMA Hisae  帝京大学, 医学部, 講師 (30147102)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords融合細胞ワクチン / 胃癌 / TS-1 / 化学療法 / 樹状細胞 / 併用療法 / プロテオーム / ヒートショックプロテイン / 株化細泡 / 癌ワクチン療法
Research Abstract

切除不能進行・再発胃癌を対象に、融合細胞ワクチンと化学療法(TS-1)の併用療法による第I/II相臨床試験を行った。全例にgrade 3以上の有害事象を認めなかった。臨床効果は、融合細胞ワクチンとTS-1併用群でPR3例・SD5例・PD2例、TS-1単独群でPR3例、SD3例、PD4例であった。併用群のPR・SD症例で、CTLの誘導を認めた。融合細胞とTS-1の併用療法は安全に施行でき、腫瘍特異免疫も誘導可能であることから、その有用性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2009 2008 2007 Other

All Journal Article (19 results) (of which Peer Reviewed: 7 results) Presentation (34 results)

  • [Journal Article] Efficient CTL productivity of modified fusion cells by increase of HSP 702009

    • Author(s)
      Koide H, Iinuma H, et al.
    • Journal Title

      Oncol Rep 21

      Pages: 737-746

    • Related Report
      2008 Final Research Report
  • [Journal Article] Efficient CTL productivity of modified fusion cells by increase of heat shock protein 70.2009

    • Author(s)
      Koide T, Iinuma H., et. al.
    • Journal Title

      Oncol. Reports 21(3)

      Pages: 737-746

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of 5-fluorouracil metabolic enzyme genes in Dukes stage B and C colorectal cancer patients treated with 5-fluorouracil based adjuvant chemotherapy2008

    • Author(s)
      Yamada H, Iinuma H, et al.
    • Journal Title

      Oncol Rep 19

      Pages: 729-735

    • Related Report
      2008 Final Research Report
  • [Journal Article] Hematogeneous metastasis in gastric cancer requires isolated tumor cells and expression of vascular endothelial2008

    • Author(s)
      Mimori T, I inuma H, et al.
    • Journal Title

      Clin Cancer Res 14

      Pages: 2609-2616

    • Related Report
      2008 Final Research Report
  • [Journal Article] 細胞融合とプロテオーム解析を用いた癌治療の新たな標的分子の探索2008

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Journal Title

      臨床免疫・アレルギー科 50(6)

      Pages: 728-730

    • Related Report
      2008 Final Research Report
  • [Journal Article] 細胞融合とプロテオーム解析による新規標的分子の探索2008

    • Author(s)
      飯沼久恵, 沖永功太
    • Journal Title

      Biotherapy 22(4)

      Pages: 248-254

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prognostic value of 5-FU metabolic enzyme in Dukes' stage B and C colorectal cancer patients treated by oral 5-FU-based adjuvant chemotherapy.2008

    • Author(s)
      Yatmada H, Iinuma H., et al
    • Journal Title

      Oncol. Reports 19

      Pages: 729-735

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hematogenous metastasis in gastric cancer requires isolated tumor cells and expression of vascular endothelial growth factor receptor-1.2008

    • Author(s)
      Mimori K, Iinuma H, et al.
    • Journal Title

      Clin Cancer Res. 14(9)

      Pages: 2609-2616

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 融合細胞ワクチン療法2008

    • Author(s)
      飯沼久恵, 冲永功太
    • Journal Title

      Biotherapy 22(6)

      Pages: 389-398

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 細胞融合とプロテオーム解析を用いた癌治療の新たな標的分子の探索2008

    • Author(s)
      飯沼久恵, 冲永功太
    • Journal Title

      臨床免疫・アレルギー科 50(6)

      Pages: 728-730

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of 5-fluorouracil metabolic enzyme genes in Dukes stage B and C colorectal cancer patients treated with 5-fluorouracil based adjuvant chemotherapy.2008

    • Author(s)
      H. Yamada, H. Iinuma, T. Watanabe
    • Journal Title

      Oncol Rep 19

      Pages: 729-735

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective study of quantitative CEA and CK20 mRNA detection in peritoneal washes to predict peritoneal recurrence in gastric carcinoma patients2007

    • Author(s)
      Tamura H, linuma H, et al.
    • Journal Title

      Oncol Rep 17

      Pages: 667-672

    • Related Report
      2008 Final Research Report
  • [Journal Article] IL-I2, IL-18遺伝子導入腫瘍細胞・樹状細胞の融合細胞による腫瘍免疫療法2007

    • Author(s)
      飯沼久恵
    • Journal Title

      臨床免疫・アレルギー科 47(1)

      Pages: 109-116

    • Related Report
      2008 Final Research Report
  • [Journal Article] 癌細胞と樹状細胞との融合細胞ワクチンを用いた癌免疫療法2007

    • Author(s)
      飯沼久恵・沖永功太
    • Journal Title

      Biotherapy 21(1)

      Pages: 48-55

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prospective study of quantitative CEA and CK20 mRNA detection in peritoneal washes to predict peritoneal recurrence in gastric carcinoma patients.2007

    • Author(s)
      N. Tamura, H. Iinuma, T. Takada.
    • Journal Title

      Oncol Rep 17

      Pages: 667-672

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid genetic diagnosis with transxription -reverse transcription concerted reaction system for peritoneal recurrence and survival in colorectal cancer patients.2007

    • Author(s)
      T. Hayama, H. Iinuma, T. Watanabe
    • Journal Title

      Oncol Rep 18

      Pages: 779-784

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌細胞と樹状細胞との融合細胞ワクチンを用いた癌免疫療法2007

    • Author(s)
      飯沼 久恵、沖永 功太
    • Journal Title

      Biotherapy 21

      Pages: 48-55

    • Related Report
      2007 Annual Research Report
  • [Journal Article] IL-12,IL-18遺伝子導入腫瘍細胞・樹状細胞の融合細胞による腫瘍免疫療法2007

    • Author(s)
      飯沼 久恵
    • Journal Title

      臨床免疫・アレルギー科 47

      Pages: 109-116

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 融合細胞ワクチン療法

    • Author(s)
      飯沼久恵, 沖永功太
    • Journal Title

      Biotherapy

    • Related Report
      2008 Final Research Report
  • [Presentation] 進行・再発食道癌の放射線化学療法併用新規ペプチドワクチン療法2008

    • Author(s)
      飯沼久恵, 冲永功, 他
    • Organizer
      日本バイオセラピイ学会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 消化器癌幹細胞を指標とした腹膜再発の予測診断と臨床的意義2008

    • Author(s)
      飯沼久恵, 冲永功太, 他
    • Organizer
      日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Efficient of HSP 70-peptide complex vaccine derived from fusion cells of TLR-stimulated DCs and heat-stressed tumor cells.2008

    • Author(s)
      Iinuma H, Okinaga K
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 融合細胞のCD4+ThとCD8+memory CTL誘導2008

    • Author(s)
      飯沼久恵, 冲永功太, 他
    • Organizer
      癌免疫外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 消化器癌幹細胞を指標とした腹膜再発予測診断の臨床的意義2008

    • Author(s)
      佐野宏賢・飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸癌幹細胞の特徴と microRNA発現2008

    • Author(s)
      田村純子, 飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] IEFを用いた上部消化管外科周術期栄養管理の検討2008

    • Author(s)
      堀川昌宏・飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行・再発食道癌の放射線化学療法併用新規ペプチドワクチン療法2008

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 改良型融合細胞ワクチンの抗腫瘍免疫能とHSPペプチド複合体の関与2008

    • Author(s)
      小出泰平・飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 改良型融合細胞ワクチンによる免疫抑制解除2008

    • Author(s)
      石田えり・飯沼久恵・沖永功太, 他
    • Organizer
      第21回日本バイオセラピイー学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 消化器癌幹細胞を指標とした腹膜再発の予測診断と臨床的意義2008

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第46回日本癌治療学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of HSP 70-peptide complex vaccine derived from fusion cells of TLR-stimulated DCs and heat-stressed tumor cells2008

    • Author(s)
      Hisae Iinuma, Kota Okinaga., et al.
    • Organizer
      67^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Final Research Report
  • [Presentation] Efficient cross- presentation of heat shock protein 70-peptode complex from fusion cells by TLR-stimulated dendritic cell and heat-stressed tumor cells2008

    • Author(s)
      Hisae Tinuma, Kota Okinaga, et al.
    • Organizer
      11^<th> liposome research days conference
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report
  • [Presentation] 融合細胞から分離したHSP70ペプチド複合体の抗腫瘍免疫誘導2008

    • Author(s)
      小出泰平・飯沼久恵・沖永功太, 他
    • Organizer
      第29回癌免疫外科研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌の脾臓における regulatory T細胞の動態解析2008

    • Author(s)
      飯沼久恵・沖永功太
    • Organizer
      第21回日本小児脾臓研究会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Phase I clinical trial of DC-tumor fusion vaccine in patients with gastrointestinal cancer.2008

    • Author(s)
      Iinuma H, Okinaga K, et al
    • Organizer
      米国癌学会 AACR
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 樹状細胞ワクチン療法における腫瘍抗原感作法の違いによる抗腫瘍免疫の誘導2007

    • Author(s)
      伊藤篤志・飯沼久恵・沖永功太, 他
    • Organizer
      第20回日本バイオセラピイー学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 胃癌症例におけるTRC法による腹膜再発の迅速予測診断2007

    • Author(s)
      田村純子・飯沼久恵・沖永功太, 他
    • Organizer
      第20回日本バイオセラピイー学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 切除不能進行および再発胃癌に対するTS-1療法とTS-1+PSK療法の多施設共同無作為化第II相比較臨床試験2007

    • Author(s)
      寺島雅典・飯沼久恵, 他
    • Organizer
      第20回日本バイオセラピイー学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 樹状細胞と腫瘍細胞の融合細胞により分離した heat shock protein 70とペプチド複合体による抗腫瘍免疫増強効果2007

    • Author(s)
      中村将薫・飯沼久恵・沖永功太, 他
    • Organizer
      第20回日本バイオセラピイー学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞融合とプロテオーム解析による新規標的分子の探索2007

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第20回日本バイオセラピイー学会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞融合とプロテオーム解析による新規標的分子の探索2007

    • Author(s)
      飯沼 久恵・沖永 功太, 他
    • Organizer
      第20回 日本バイオセラピイ学界学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 樹状細胞と腫瘍細胞の融含細胞により分離した heat shock protein 70とペプチド複合体による抗腫瘍免疫増強効果2007

    • Author(s)
      飯沼 久恵・沖永 功太, 他
    • Organizer
      第20回 日本バイオセラピイ学界学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 樹状細胞ワクチン療法における腫瘍抗原感作法の違いによる抗腫瘍免疫の誘導2007

    • Author(s)
      伊藤 篤志・飯沼 久恵・沖永 功太, 他
    • Organizer
      第20回 日本バイオセラピイ学界学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 胃癌症例におけるTRC法による腹膜再発の迅速予測診断2007

    • Author(s)
      田村 純子、飯沼 久恵、沖永 功太, 他
    • Organizer
      第20回 日本バイオセラピイ学界学術集会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] A novel rapid genetic diagnosis for peritoneal recurrence in gastrointestinal cancer patients.2007

    • Author(s)
      Hisae Iinuma, Kota Okinaga, et. al.
    • Organizer
      66th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテオーム解析と細胞融合を用いたに新規標的分子の探索2007

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] プロテオーム解析と細胞融合を用いたに新規標的分子の探索2007

    • Author(s)
      飯沼 久恵・沖永 功太, 他
    • Organizer
      第45回 日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic diagnosis for peritoneal recurrence in gastrointestinal cancer patients2007

    • Author(s)
      Hisae Iinuma, Kota Okinaga, et. al.
    • Organizer
      2007 ASCO Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-06-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腫瘍細胞と樹状細胞との融合細胞により分離した heat sllock 70 (HSP70) によるT細胞の活性化についての検討2007

    • Author(s)
      小出泰平・飯沼久恵・Gong Jianlin
    • Organizer
      第28回癌免疫外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 細胞融合とプロテオーム解析による腫瘍血管関連標的分子の探索2007

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第28回癌免疫外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 消化器癌症例におけるTRC法による腹膜再発術中予測診断2007

    • Author(s)
      飯沼久恵・沖永功太, 他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-13
    • Related Report
      2008 Final Research Report
  • [Presentation] A novel rapid genetic diagnosis for peritoneal recurrence in gastrointestinal cancer patients2007

    • Author(s)
      Hisae Iinuma. Kota Okinaaa, et al.
    • Organizer
      66^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic diagnosis for peritoneal recurrence in gastrointestinal cancer patients2007

    • Author(s)
      Kota Okinaga, et al
    • Organizer
      43th ASCO Annual Meeting Hisae Iinuma
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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