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The analysis of the mechanism for accommodation in ABO incompatible transplantations

Research Project

Project/Area Number 19591496
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionTokyo Women's Medical University

Principal Investigator

ISHIDA Hideki  Tokyo Women's Medical University, 医学部, 准教授 (60246543)

Co-Investigator(Kenkyū-buntansha) TANABE Kazunari  東京女子医科大学, 医学部, 教授 (80188359)
白川 浩希  東京女子医科大学, 医学部, 助教 (60263539)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎移植 / 血液型不適合 / Accommodation / 免疫寛容 / 腎臓 / 移植 / 免疫学的寛容 / 血液型不適合腎臓移植 / 抗血液型抗体
Research Abstract

血液型を間違えた輸血(異型輸血)を施行すると溶血を起こし死にまで至る。1989年から当大学当科では血液型の異なる腎臓移植を施行してきた。1990 年代後半より開発された免疫抑制剤はいまやこのような難解な移植をもほぼ100%近い成績にまで達成させている。しかし今も昔もどのようにしてこれらの血液型の異なる腎臓がレシピエントに許容され長い間優れた腎臓の機能を発揮させることができるのか、不明な点は少なくない。この研究は血液型不適合移植における免疫的な機序の解明を目的とした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (20 results)

All 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (7 results)

  • [Journal Article] Efficacy of dexoxyspergualine for antibody mediated rejection and proteinuria after kidney transplantation2008

    • Author(s)
      石田英樹、田邉一成
    • Journal Title

      Ther Clin Risk Manag 4(3)

      Pages: 641-644

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Poor graft outcome in recipients with de novo donor specific antibody after living related kidney transplantation2008

    • Author(s)
      Li X、石田英樹、田邉一成、他4名
    • Journal Title

      Transpl Int 13

      Pages: 432-436

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of splenectomy for chronic active antibody mediated rejection after renal transplantation2008

    • Author(s)
      石田英樹、尾本和也、田邉一成、他4名
    • Journal Title

      Transpl Int 11

      Pages: 602604-602604

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunological status in three patients2008

    • Author(s)
      宮本直志、石田英樹、田邉一成、他5名
    • Journal Title

      thirty years after living related renal transplantation ; antibody production in long term survivors. Transplant Immunology 18(4)

      Pages: 368-372

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of renal transplant protocol biopsies in ABO-incompatible kidney transplantation2008

    • Author(s)
      瀬戸口誠、石田英樹、田邉一成、他6名
    • Journal Title

      Am J Transplant 18(4)

      Pages: 86-94

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of dexoxyspergualine for antibody mediated rejection and proteinuria after kidney transplantation.2008

    • Author(s)
      石田英樹, 田邉一成
    • Journal Title

      Ther Clin Risk Manag 4(3)

      Pages: 641-644

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poor graft outcome in recipients with de novo donor specific an tibody after living related kidney transplantation.2008

    • Author(s)
      Li X, 石田英樹, 田邉一成
    • Journal Title

      Transpl Int. 13

      Pages: 432-436

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of splenectomy for chronic active antibody mediated rejection after renal transplantation.2008

    • Author(s)
      石田英樹, 尾本和也, 田邉一成
    • Journal Title

      Transpl Int. 11

      Pages: 602-604

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological status in three patients thirty years after LRKTx2008

    • Author(s)
      Miyamoto N., et. al.
    • Journal Title

      Transplant Immunology 18(4)

      Pages: 368-372

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal transplantation after myeloablative and non-myeloablative hematopoietic cell transplantation from the same donor2007

    • Author(s)
      田中俊明、石田英樹、田邉一成、他4名
    • Journal Title

      Int J Urol 14(11)

      Pages: 1044-45

    • NAID

      10019799554

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of immunosuppressive regimens in ABO-incompatible living related kidney transplantation-single centre analysis-2007

    • Author(s)
      石田英樹、宮本直志、田邉一成、他4名
    • Journal Title

      Am J Transplant 7(4)

      Pages: 825-831

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anlaysis of protocol biopsies in ABO-incompatible kidney transplantations2007

    • Author(s)
      Setoguchi, et. al.
    • Journal Title

      Am J Transplant 8(1)

      Pages: 86-89

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal transplantation after myeloablative and non-myeloablative haematopoietic cell transplantation from the same donor.2007

    • Author(s)
      Tanaka T., et. al.
    • Journal Title

      Int J Urology 14(11)

      Pages: 1044-1045

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] サテライトシンポジウム、既存抗体陽性腎移植における新戦略2008

    • Author(s)
      石田英樹
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 既存抗体陽性腎移植における新戦略2008

    • Author(s)
      石田英樹サテライトシンポジウム
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植における基本手技(レシピエント)2008

    • Author(s)
      石田英樹
    • Organizer
      第96回日本泌尿器学会総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] リツキシマブの光と影2007

    • Author(s)
      石田英樹、シンポジウム
    • Organizer
      第14回腎移植血管外科研究会
    • Place of Presentation
      岩手花巻
    • Related Report
      2008 Final Research Report
  • [Presentation] 血液型不適合移植と抗体関連型拒絶反応対策の進歩2007

    • Author(s)
      石田英樹、シンポジウム
    • Organizer
      第50回日本腎臓学会
    • Place of Presentation
      浜松
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植最近の話題2007

    • Author(s)
      石田英樹、シンポジウム
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗体陽性例に対する腎臓移植について2007

    • Author(s)
      石田英樹
    • Organizer
      日本泌尿器科学会総会シンポジウム
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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