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Significance of activation of lymphocytic dendritic cells in induction of tumor immunity

Research Project

Project/Area Number 19591508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionHiroshima University

Principal Investigator

ARIHIRO Koji  Hiroshima University, 病院, 准教授 (70232064)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Sigeru  広島大学, 病院, 講師 (00403527)
TANABE Kazuteru  広島大学, 病院, 講師 (40379847)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsAutophagy / 治療抵抗性 / 乳癌 / 術前化学療法 / LC3 / GATE-16 / PI-3K / Breast cancer / Dendritic cell
Research Abstract

術前化学療法によるヒト乳癌の腫瘍縮小効果と治療抵抗性を評価するため、樹状細胞の活性化とautophagyに注目して乳癌細胞の質的変化を客観的に検討することを試みた。本学外科で術前化学療法を施行された56例を対象として、化学療法による細胞内恒常性の破綻のため蓄積する不要な蛋白質の分解に先立ってautophagosomeの形成に必須なLC3, GABA受容体関連蛋白質、Golgi-associatedATPase enhancer(GATE-16)またAtg3, Atg4B, Atg7, Atg16L などの因子の発現を免疫組織化学的染色法により検討した。その結果、Grade2と判定した16例中4例にLC3、GATE-16、Atg4B、Atg7、Atg16Lの発現を認めた。胞体内に空胞変性を伴い核の膨化を示す高度の変性像と判定した乳癌細胞でもautophagyにより生存の可能性があることが示されたが、今回対象とした56例では未だ再発例や遠隔転移を伴う死亡例はなく、無病再発や生存を指標とした評価は困難であった。一方、未成熟・成熟樹状細胞(pDC, mDC)の発現をCD1a、CD11c、CD123、CD80、CD83、CD86 をマーカーとして検討したが、これらを発現する細胞は殆どなく、pDC, mDCの関与を検討するためには化学療法開始後4週間後あるいは8週間後の生検標本を用いるべきであろうと考えた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (42 results)

All 2008 2007 2006

All Journal Article (42 results) (of which Peer Reviewed: 41 results)

  • [Journal Article] Expression of hypoxia-inducible factor-1{alpha} and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours2008

    • Author(s)
      T. Kubo, T. Sugita, S. Shimose, T. Matsuo, K. Arihiro, and M. Ochi
    • Journal Title

      J Bone Joint Surg Br 90-B(3)

      Pages: 364-370

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 乳腺乳頭部腺腫の1例2008

    • Author(s)
      片岡健、田中友加、小川勝成、尾田三世、有広光司
    • Journal Title

      日本臨床細胞学会雑誌 47(2)

      Pages: 156-157

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma2008

    • Author(s)
      Miki D, Aikata H, Uka K, Saneto H, Kawaoka T, Azakami T, Takaki S, Jeong SC, Imamura M, Kawakami Y, Takahashi S, Itamoto T, Asahara T, Arihiro K, Chayama K
    • Journal Title

      J Gastroenterol 43(7)

      Pages: 550-557

    • NAID

      10021937291

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose2008

    • Author(s)
      Hamatani K, Eguchi H, Ito R, Mukai M, Takahashi K, Taga M, Imai K, Cologne J, Soda M, Arihiro K, Fujihara M, Abe K, Hayashi T, Nakashima M, Sekine I, Yasui W, Hayashi Y, Nakachi K
    • Journal Title

      Cancer Res 68(17)

      Pages: 7176-7182

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of vascular endothelial growth factor-C and -D mRNA in breast cancer2008

    • Author(s)
      Teramoto S, Arihiro K, Koseki M, Kataoka T, Asahara T, Ohdan H
    • Journal Title

      Hiroshima J Med Sci 57(2)

      Pages: 73-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell delivery system using magnetically labeled mesenchymal stem cells and an external magnetic device for clinical cartilage repair2008

    • Author(s)
      Kobayashi T, Ochi M, Yanada S, Ishikawa M, Adachi N, Deie M, Arihiro K.
    • Journal Title

      Arthroscopy 24(1)

      Pages: 69-76

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia2008

    • Author(s)
      Hyogo H, Tazuma S, Arihiro K, Iwamoto K, Nabeshima Y, Inoue M, Ishitobi T, Nonaka M, Chayama K
    • Journal Title

      Metabolism 57(12)

      Pages: 1711-1718

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma2008

    • Author(s)
      Sentani K, Oue N, Tashiro T, Sakamoto N, Nishisaka T, Fukuhara T, Taniyama K, Matsuura H, Arihiro K, Ochiai A, Yasui W
    • Journal Title

      Am J Surg Pathol 32(8)

      Pages: 1182-1189

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scalp metastasis from malignant fibrous histiocytoma of bone2008

    • Author(s)
      Kubo, S. Shimose , T. Matsuo , K. Arihiro, M. Ochi
    • Journal Title

      Journal of the American Academy of Dermatology 59(5)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 乳管腺腫2008

    • Author(s)
      有広光司
    • Journal Title

      病理と臨床 26(11)

      Pages: 1132-1134

    • Related Report
      2008 Final Research Report
  • [Journal Article] 術前化学療法, 胸膜肺全摘術後に再発をきたした線維形成性悪性胸膜中皮腫の1剖検例2008

    • Author(s)
      沖田理貴, 清水克彦, 三村剛史, 恵美学, 川崎由香里, 宮田義浩, 有廣光司, 岡田守人
    • Journal Title

      癌の臨床 54(9)

      Pages: 771-777

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of elaluations for hormone receptors in breast carcinoma using two manual and three automated immunohistochemical assays2008

    • Author(s)
      Arihiro K, Umemura S, Kurosumi M, Moriya T, Oyama T, Yamashita H, Umekita Y, Komoike Y, Shimizu C, Fukushima H, Kajiwara H, Akiyama F
    • Journal Title

      Am J Clin Pathol 127

      Pages: 356-365

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiling with microarray and SAGE identifies PLUNC as a marker for hepatoid adenocarcinoma of the stomach2008

    • Author(s)
      Sentani K
    • Journal Title

      Mod Pathol 21

      Pages: 464-475

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of hypoxia-inducible factor-lalpha and its relationship to tumour angiogenesis and cell proliferation in cartilage tumours2008

    • Author(s)
      Kubo T
    • Journal Title

      J Bone Joint Surg Br 90

      Pages: 364-370

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma2008

    • Author(s)
      Miki D
    • Journal Title

      J Gastroenterol 43

      Pages: 550-557

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose.2008

    • Author(s)
      Hamatani K
    • Journal Title

      Cancer Res 68

      Pages: 7176-7182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of vascular endothelial growth factor-C and -D mRNA in breast cancer2008

    • Author(s)
      Teramoto S
    • Journal Title

      Hiroshima J Med Sci 57

      Pages: 73-78

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel cell delivery system using magnetically labeled mesenchymal stem cells and an external magnetic device for clinical cartilage repair2008

    • Author(s)
      Kobayashi T
    • Journal Title

      Arthroscopy 24

      Pages: 69-76

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia2008

    • Author(s)
      Hyogo H
    • Journal Title

      Metabolism 57

      Pages: 1711-1718

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma2008

    • Author(s)
      Sentani K
    • Journal Title

      Am J Surg Pathol 32

      Pages: 1182-1189

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Scalp metastasis from malignant fibrous histiocytoma of bone.2008

    • Author(s)
      Kubo T
    • Journal Title

      J Am Acad Dermatol 59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 乳管腺腫2008

    • Author(s)
      有廣光司
    • Journal Title

      病理と臨床 26

      Pages: 1132-1134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of BRAF point mutation in adult papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose2007

    • Author(s)
      Takahashi K, Eguchi H, Arihiro K, Ito R, Koyama K, Soda M, Cologne J, Hayashi Y Nakata Y, Nakachi K and Hamatani K
    • Journal Title

      Mol Carcinog 46

      Pages: 242-248

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model2007

    • Author(s)
      Ogawa T, Tashiro H, Miyata Y, Ushitora Y, Fudaba Y, Kobayashi T, Arihiro K, Okajima M and Asahara T
    • Journal Title

      Am J Transplant 7

      Pages: 347-355

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of fixation, processing and evaluation criteria on immunohistochemical detection of hormone receptors in breast cancer2007

    • Author(s)
      Oyama T, Ishikawa Y, Hayashi M, Arihiro K, Horiguchi J
    • Journal Title

      Breast Cancer 14

      Pages: 182-188

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potential functional role of plasmacytoid dendritic cells in cancer immunity2007

    • Author(s)
      Kim R, Emi M, Tanabe K and Arihiro K
    • Journal Title

      Immunol 121

      Pages: 149-157

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epithelioid trophoblastic tumor of the lung2007

    • Author(s)
      Urabe S, Fujiwara H, Miyoshi H, Arihiro K, Soma H, Yoshihama I, Mineo S, Kudo Y
    • Journal Title

      J Obstet Gynaecol Res 33(3)

      Pages: 397-401

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma2007

    • Author(s)
      Mukai S, Hiyama T, Tanaka S, Yoshihara M, Arihiro K, Chayama K
    • Journal Title

      World J Gastroenterol 13(29)

      Pages: 3932-3938

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer2007

    • Author(s)
      Kaneko I, Tanaka S, Oka S, Yoshida S, Hiyama T, Arihiro K, Shimamoto F, Chayama K
    • Journal Title

      World J Gastroenterol 13(28)

      Pages: 3829-3835

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝細胞癌と肝内結石症に起因したと思われる胆管内発育型肝内胆管癌の同時性重複癌の1例2007

    • Author(s)
      小川尚之、板本敏行、田代裕尊、浅原利正、有広光司、北本幹也
    • Journal Title

      日臨外会誌 68(6)

      Pages: 1528-1534

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis2007

    • Author(s)
      Liang S, Wei FY, Wu YM, Tanabe K, Abe T, Oda Y, Yoshida Y, Yamada H, Matsui H, Tomizawa K, Takei K
    • Journal Title

      J Neurochem 102(5)

      Pages: 1466-1476

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kidney metastasis of resected early gastric carcinoma2007

    • Author(s)
      Wada Y, Yoshida K, Hihara J, Tanabe K, Ukon K
    • Journal Title

      report of a case. Surg 37(3)

      Pages: 248-250

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines2007

    • Author(s)
      Wada Y, Yoshida K, Tsutani Y, Shigematsu H, Oeda M, Sanada Y, Suzuki T, Mizuiri H, Hamai Y, Tanabe K, Ukon K, Hihara J
    • Journal Title

      Oncol Rep 17(1)

      Pages: 161-167

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer immunoediting from immune surveillance to immune escape2007

    • Author(s)
      Kim R, Emi M, Tanabe K
    • Journal Title

      Immunology 121(1)

      Pages: 1-14

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of elaluations for hormone receptors in breast carcinoma using two manual and three automated immunohistochemical assays2007

    • Author(s)
      Arihiro K
    • Journal Title

      Am J Clin Pathol 127

      Pages: 356-365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The presence of BRAF point mutation in adlut papillary thyroid carcinomas from atomic bomb survivors correlates with radiation dose2007

    • Author(s)
      Takahashi K
    • Journal Title

      Mol Carcinog 46

      Pages: 242-248

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model2007

    • Author(s)
      Ogawa T
    • Journal Title

      Am J Transplant 7

      Pages: 347-355

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of fixation, processing and evaluation criteria on immunohistochemical detection of hormone receptors in breast cancer2007

    • Author(s)
      Oyama T
    • Journal Title

      Breast Cancer 14

      Pages: 182-188

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential functional role of plasmacytoid dendritic cells in cancer immunity2007

    • Author(s)
      Kim R
    • Journal Title

      Immunol 121

      Pages: 149-157

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma2007

    • Author(s)
      Mukai S
    • Journal Title

      World J Gastroenterol 13

      Pages: 3932-3938

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer2007

    • Author(s)
      Kaneko I
    • Journal Title

      World J Gastroenterol 13

      Pages: 3829-3835

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the orotate phosphoribosyl-transferase gene enhances the effect of 5-fluorouracil on gastric cancer cell lines2006

    • Author(s)
      Taomoto J, Yoshida K, Wada Y, Tanabe K, Konishi K, Tahara H, Fukushima M
    • Journal Title

      Oncology 70(6)

      Pages: 458-464

    • Related Report
      2008 Final Research Report
    • Peer Reviewed

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Published: 2007-04-01   Modified: 2016-04-21  

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