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Study of the optimal dose of some chemotherapeutic drugs forenhancement of cancer specific immunotherapy by dendritic cell

Research Project

Project/Area Number 19591536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionChiba University

Principal Investigator

TAKAHASHI Yutaka  Chiba University, 大学院・医学研究院, 客員教授 (10179541)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Masato  武蔵野大学, 附置研究所, 客員教授 (10243718)
MINAMOTO Toshinari  金沢大学, がん研究所, 教授 (50239323)
Co-Investigator(Renkei-kenkyūsha) OKAMOTO Masato  武蔵野大学, 附置研究所, 客員教授 (10243718)
MINAMOTO Toshinari  金沢大学, がん研究所, 教授 (50239323)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords胃十二指腸外科学 / 樹状細胞療法 / 化学療法 / 白血球減少 / MTD / 樹状細胞 / CPT-11 / Docetaxe1 / OK432
Research Abstract

樹状細胞を用いた癌特異免疫療法において、併用する各種抗癌剤の適量について検討した。その結果、抗癌剤単独では最も効果が高いとされているMTD (maximumtolerated dose)よりも低い濃度で、併用効果が高いことが判明した。またその時のマウスの骨髄抑制を検討したところ、軽度から中等度であった。以上から、樹状細胞療法と抗癌剤の併用を臨床応用する場合は、軽度の骨髄抑制を指標として抗癌剤の量を調節することが重要であることが示唆された。ombination in VEGF-targeted and-non-targeted anti-angiogenesis therapya。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (2 results) Book (1 results)

  • [Journal Article] 胃癌のバイオマーカー2009

    • Author(s)
      高橋豊
    • Journal Title

      Biotherapy 23

      Pages: 92-97

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Tumor dormancy therapy2008

    • Author(s)
      高橋豊
    • Journal Title

      日本保険医学会雑誌 106

      Pages: 165-172

    • NAID

      10020021889

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ヒト胃癌の同所性移植および経門脈(経脾)による肝転移モデル(ヌードマウス)2008

    • Author(s)
      高橋豊, I. J. Fidler
    • Journal Title

      がん転移研究の実験手法

    • Related Report
      2008 Annual Research Report
  • [Journal Article] AdjuvantImmunochemotherapy with Protein-boundPolysaccharide K for Colon Cancer inRelation to Oncogenic beta-catenin Activation2007

    • Author(s)
      Yamashita K, Nakazato H, Ito K, OugolkovAV, Kitakata H, Yasumoto K, Omote K, MaiM, Takahashi Y, Minamoto T
    • Journal Title

      Diseases of Colon and Rectum 50

      Pages: 1182-1187

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of GSK3|*beta*|activity attenuates proliferation of humancolon cancer cells in rodents2007

    • Author(s)
      Shakoori A, Mai W Miyashita K, YasumotoK, Takahashi Y, Ooi A, Kawakami K,Minamoto T.
    • Journal Title

      CancerScience 98

      Pages: 1388-1393

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of primary small cellcarcinoma of the breast2007

    • Author(s)
      Kitakata H, Yasumoto K, Sudo Y, Minato H, Takahashi Y
    • Journal Title

      Breast Cancer 14

      Pages: 414-419

    • NAID

      10019800636

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvant Immunochemotherapy with Protein-bound Polysaccharide K for Colon Cancer in Relation to Oncogenic beta-catenin Activation2007

    • Author(s)
      Yamashita K, Takahashi Y, et. al.
    • Journal Title

      Diseases of Colon and Rectum 50

      Pages: 1182-1187

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of GSK31*beta activity attenuates proliferation of human colon cancer cells in rodents.2007

    • Author(s)
      Shakoori A, Takahashi Y, et al
    • Journal Title

      Cancer Science 98

      Pages: 1388-1393

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo combination therapy of anti-VEGF antibody and DFMO on VEGF-dependent and -independent tumors : Significance of the combination in VEGF-targeted and-non-targeted anti-angiogenesis therapy

    • Author(s)
      Takahashi Y and Nishioka K
    • Journal Title

      Recent advance of metastaticgastrointestinal cancers (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo combination therapy of anti-VEGF antibody and DFMO on VEGF-dependent and -independent tumor:Significance of the combination in Vegf-targeted and -non-targeted anti-angiogenesis therapy

    • Author(s)
      Takahashi Y, Nishiola K
    • Journal Title

      Recent advance of metastatic gastrointetinal cancers (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] RANDOMIZED PHASE II CLINICAL TRIAL OF TAILORED IRINOTECAN (CPT-11) PLUS S-1 VERSUS S-1 IN PATIENTS WITH ADVANCED OR RECURRENT GASTRIC CARCINOMA AS THE FIRST-LINE CHEMOTHERAPY2008

    • Author(s)
      Takahashi Y, et al.
    • Organizer
      ESMO 2008
    • Place of Presentation
      Stockholm
    • Year and Date
      2008-09-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANDOMIZED PHASE IICLINICAL TRIAL OF TAILORED IRINOTECAN(CPT-11) PLUS S-1 VERSUS S-1 IN PATIENTSWITH ADVANCED OR RECURRENT GASTRICCARCINOMA AS THE FIRST-LINE CHEMOTHERAPY CLINICAL TRIAL OF TAILORED IRINOTECAN (CPT-11) PLUS S-1 VERSUS S-1 IN PATIENTS WITH ADVANCED OR RECURRENT GASTRIC CARCINOMA AS THE FIRST-LINE CHEMOTHERAPY2008

    • Author(s)
      Takahashi Y, et.al.
    • Organizer
      ESMO
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2008 Final Research Report
  • [Book] ヒト胃癌の同所性移植および経門脈(経脾)による肝転移モデル(ヌードマウス)2008

    • Author(s)
      高橋 豊、IJ Fidler
    • Publisher
      がん転移研究の実験手法, 金芳堂
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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