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The effect of splenic venous hemodynamics on liver regeneration and carcinogenesis.

Research Project

Project/Area Number 19591604
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNippon Medical School

Principal Investigator

YOSHIDA Hiroshi  Nippon Medical School, 医学部, 准教授 (60246999)

Co-Investigator(Kenkyū-buntansha) MAMADA Yasuhiro  日本医科大学, 医学部, 准教授 (40312061)
TANIAI Nobuhiko  日本医科大学, 医学部, 准教授 (20287725)
田尻 孝  日本医科大学, 大学院・医学研究科, 教授 (20163462)
秋丸 琥甫  日本医科大学, 医学部, 教授 (40142541)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血行動態 / 肝再生 / 発癌 / 遺伝子 / 脾臓
Research Abstract

肝臓と脾臓の臓器相関のメカニズムは未だ解明されていない。我々はガラクトシル人血清アルブミンジエチレントリアミン五酢酸テクネチウム(Tc-99mGSA)を用いた経脾門脈シンチグラフィー(SSP)を考案した。本検査により生理的な脾静脈の血行動態と肝細胞密度を同時に解析可能となり報告した。また我々が考案したTc-99m GSAによるSSPでは、first pass imageで生理的な脾静脈血行動態を把握できると同時に、非観血的な測定が難しい門脈血に占める脾静脈血の割合、脾静脈血の肝内分布状況や濃度、流量が測定できる。更にstatic imageにより肝細胞数、肝細胞密度を同時に測定することが可能となった。この手法で肝細胞数に比して脾静脈血流量が多い領域(葉)は正常肝および慢性肝炎では右葉で、肝硬変では左葉であることを発表した(Hepatogastroenterol 2005 ; 52 : 1313-1319)。これは肝硬変の右葉萎縮、左葉代償性肥大のメカニズム解明の手掛かりと考える。さらに脾臓より多く産生されるtransforming growth factor Beta(TGFβ)が肝不全に与える影響を検討し報告した(Gastroenterology 2005 ; 129 : 1654-1662)。
本研究ではさらに脾静脈血行動態の研究に取り組んだ。門脈圧亢進症における脾静脈血行動態の研究を進め、脾静脈血の流入減少が肝に及ぼす影響を更に追及した(Yoshida H.et al.Simultaneous evaluation of portal hemodynamics and liver function by scintiphotosplenoportography in pediatric recipients of living-donor liver transplants Hepato-Gasmenterology 2009 ; 56 : 819-823.)。肝臓と脾臓の臓器相関のメカニズムの一部が解明された。

Report

(4 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007 Other

All Journal Article (19 results) (of which Peer Reviewed: 10 results) Presentation (24 results) Book (1 results)

  • [Journal Article] Simultaneous evaluation of portal hemodynamics and liver function by scintiphotosplenoportography in pediatric recipients of living-donor liver transplants2009

    • Author(s)
      Yoshida H.
    • Journal Title

      Hepato-Gastroenterology 56

      Pages: 819-823

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions between anti-ulcer drugs and non-steroidal anti-inflammatory drugs in cirrhotic patients with bleeding esophagogastric varices2009

    • Author(s)
      Yoshida H.
    • Journal Title

      Hepato-Gastroenterology 56

      Pages: 1366-1370

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New trends in surgical treatment for portal hypertension2009

    • Author(s)
      Yoshida H.
    • Journal Title

      Hepatology Reserch 39

      Pages: 1044-1051

    • NAID

      10027405394

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Silicon drain with channels along the sides for internal biliary stenting of hepaticojejunostomy in hepatic hilar malignancies2009

    • Author(s)
      Yoshida H.
    • Journal Title

      J Gastroenterol Hepatol 24

      Pages: 752-756

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA profiling of human intrahepatic cholangiocarcinoma cell lines reveals bilialy epithelial cell-specific microRNAs2009

    • Author(s)
      Kawahigashi Y
    • Journal Title

      J Nippon Med Sch 76

      Pages: 188-197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placement of a percutaneous transhepatic biliary stent using a silicon drain with channels along the sides for the treatment of a stenotic hepaticojejunostomy2009

    • Author(s)
      Yoshida H.
    • Journal Title

      World J Gastroenterol 15

      Pages: 4201-4203

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 門亢症とIVR-各種塞栓術の組み合わせ2009

    • Author(s)
      真々田裕宏
    • Journal Title

      日本門脈圧亢進症雑誌 15

      Pages: 348-351

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Simultaneous evaluation of portal hemodynamics and liver function by scintiphotosplenoportography in pediatric recipients of living-donor liver transplants.2009

    • Author(s)
      Yoshida H, Mamada Y, Taniai N, Hirakata A, Kawano Y, Kakinuma D, Mineta S, Tajiri T
    • Journal Title

      Hepatogastroenterol 56

      Pages: 819-823

    • Related Report
      2008 Final Research Report
  • [Journal Article] Interactions between anti-ulcer drugs and non-steroidal anti-inflammatory drugs in cirrhotic patients with bleeding esophagogastric varices.2009

    • Author(s)
      Yoshida H, Mamada Y, Taniai N, Bando K, Mineta S, Kawano Y, Kakinuma D, Kanda T, Tajiri T
    • Journal Title

      Hepatogastroenterol 56

      Pages: 1366-1370

    • Related Report
      2008 Final Research Report
  • [Journal Article] New trends in surgical treatment for portal hypertension.2009

    • Author(s)
      Yoshida H, Mamada Y, Taniai N, Tajiri T
    • Journal Title

      Hepatology Reserch 39

      Pages: 1044-1051

    • NAID

      10027405394

    • Related Report
      2008 Final Research Report
  • [Journal Article] Silicon drain with channels along the sides for internal biliary stenting of hepaticojejunostomy in hepatic hilar malignancies.2009

    • Author(s)
      Yoshida H, Mamada Y, Taniai N, Mizuguchi Y, Kakinuma D, Ishikawa Y, Kanda T, Matsumoto S, Bando K, Akimaru K, Tajiri T
    • Journal Title

      J Gastroenterol Hepatol 24

      Pages: 752-756

    • Related Report
      2008 Final Research Report
  • [Journal Article] MicroRNA profiling of human intrahepatic cholangiocarcinoma cell lines reveals bilialy epithelial cell-specific microRNAs.2009

    • Author(s)
      Kawahigashi Y, Mishima T, Mizuguchi Y, Arima Y, Yokomuro S, Shimizu T, Kanda T, Takizawa T, Luo SS, Ishibashi O, Yoshida H, Tajiri T, Takizawa T
    • Journal Title

      J Nippon Med Sch 76

      Pages: 188-197

    • Related Report
      2008 Final Research Report
  • [Journal Article] Placement of a percutaneous transhepatic biliary stent using a silicon drain with channels along the sides for the treatment of a stenotic hepaticojejunostomy.2009

    • Author(s)
      Yoshida H, Mamada Y, Taniai N, Bando K, Mizuguchi Y, Sasaki J, Ishikawa Y, Nakamura Y, Aimoto T, Tajiri T
    • Journal Title

      World J Gastroenterol 15

      Pages: 4201-4203

    • Related Report
      2008 Final Research Report
  • [Journal Article] 門亢症とivr-各種塞栓術の組み合わせ2009

    • Author(s)
      真々田裕宏, 吉田寛, 谷合信彦, 田尻孝
    • Journal Title

      日本門脈圧亢進症雑誌 15

      Pages: 348-351

    • Related Report
      2008 Final Research Report
  • [Journal Article] 部分的牌動脈塞栓術(PSE)2008

    • Author(s)
      吉田 寛
    • Journal Title

      日本門脈圧亢進症学会雑誌 14

      Pages: 161-163

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term results of elective hepatectomy for the treatment of ruptured hepatocellular carcinoma2008

    • Author(s)
      Yoshida H
    • Journal Title

      J Hepatobiliary Pancreat Surg 15

      Pages: 178-182

    • NAID

      10024156498

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial splenic embolization2008

    • Author(s)
      Yoshida H
    • Journal Title

      Hepatology Research 38

      Pages: 225-233

    • NAID

      10024147292

    • Related Report
      2008 Annual Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New methods for the management of esophageal varices2007

    • Author(s)
      Yoshida H
    • Journal Title

      World J Gastroenterol 13

      Pages: 1641-1645

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fixation of the greater omentum for prevention of delayed gastric emptying after left hepatectomy with lymphadectomy for cholangiocellular carcinoma.2007

    • Author(s)
      Yoshida H
    • Journal Title

      J Hepatobiliary Pancreat Surg 14

      Pages: 392-396

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 当科における肝切除のクリニカルパスの変遷と功罪2009

    • Author(s)
      吉田寛
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 当科における肝細胞癌に対する肝切除術2009

    • Author(s)
      谷合信彦
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 当科における生体肝移植後血管IVR治療2009

    • Author(s)
      川野陽一
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食道胃静脈瘤破裂とunti-ulcer drugs、NSAIDsとの相互関係2009

    • Author(s)
      吉田寛
    • Organizer
      第16回日本門脈圧亢進症学会総会
    • Place of Presentation
      福島
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 門脈圧亢進症合併肝細胞癌治療における部分脾動脈塞栓術(PSE)の意義(脾摘vsPSE)2009

    • Author(s)
      谷合信彦
    • Organizer
      第16回日本門脈圧亢進症学会総会
    • Place of Presentation
      福島
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝細胞癌治療、生体肝移植における部分脾動脈塞栓術(PSE)の有用性2009

    • Author(s)
      谷合信彦
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特発性門脈圧亢進症におけるシャント手術と直達手術の比較検討2009

    • Author(s)
      吉田寛
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 教育講演 : Interventional radiology for esophagogastric varices2009

    • Author(s)
      Yoshida H
    • Organizer
      A-PHPBA 2009
    • Place of Presentation
      Thai
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Simultaneous evaluation of portal hemodynamics and liver function by scintiphotosplenoportography in pediatric recipients of living-donor liver2009

    • Author(s)
      Yoshida H
    • Organizer
      A-PHPBA 2009
    • Place of Presentation
      Thai
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 教育講演 : New trend of surgical treatment for portal hypertension.2008

    • Author(s)
      Yoshida H
    • Organizer
      JSH Single Topic Conference
    • Place of Presentation
      福岡
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] パネルディスカッション : 当科における門脈圧亢進症治療法の工夫と変遷2008

    • Author(s)
      吉田 寛
    • Organizer
      第12回日本肝臓学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食道胃静脈瘤破裂症例の検討-unti-ulcer drugs、Alcohol、NSAID_sとの相互関係を中心に2008

    • Author(s)
      吉田 寛
    • Organizer
      第108回日本外科学会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Surgical disconnection of patent paraumbilical vein in refractory hepatic encephalopathy(会長賞受賞)2008

    • Author(s)
      Yoshida H
    • Organizer
      18th APASL
    • Place of Presentation
      Korea
    • Year and Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ワークショップ:当科における食道噴門部静脈瘤に対する新しい治療戦略2007

    • Author(s)
      吉田 寛
    • Organizer
      第11回日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 教育講演:Bi-monthly versus Bi-weekly Endoscopic Variceal Ligation of Esophageal Varices2007

    • Author(s)
      Yoshida H
    • Organizer
      China-Indonesia joint International Symposium on hepatobiliary Medicine and Surgery 2007
    • Place of Presentation
      インドネシア(バリ)
    • Year and Date
      2007-08-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] 教育講演:Treatment of esophagogastric varices2007

    • Author(s)
      Yoshida H
    • Organizer
      China-Indonesia joint International Symposium on hepatobiliary Medicine and Surgery 2007
    • Place of Presentation
      インドネシア(バリ)
    • Year and Date
      2007-08-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] パネルディスカッション:当科における胃静脈瘤治療の最新の考え方2007

    • Author(s)
      吉田 寛
    • Organizer
      第61回日本食道学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-06-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] 特発性門脈圧亢進症におけるシャント手術と直達手術の比較検討

    • Author(s)
      吉田寛, 真々田裕宏, 谷合信彦, 峯田章, 川野陽一, 水口義昭, 神田知洋, 内田英二, 田尻孝
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝細胞癌治療、生体肝移植における部分脾動脈塞栓術(PSE)の有用性

    • Author(s)
      谷合信彦, 吉田寛, 真々田裕宏, 峯田章, 川野陽一, 神田知洋, 平方敦史, 柿沼大輔, 内田英二, 田尻孝
    • Organizer
      第21回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 食道胃静脈瘤破裂とunti-ulcer drugs、NSAIDsとの相互関係

    • Author(s)
      吉田寛, 真々田裕宏, 谷合信彦, 峯田章, 川野陽一, 柿沼大輔, 神田知洋, 上田純志, 内田英二, 田尻孝
    • Organizer
      第16回日本門脈圧亢進症学会総会
    • Place of Presentation
      福島
    • Related Report
      2008 Final Research Report
  • [Presentation] 門脈圧亢進症合併肝細胞癌治療における部分脾動脈塞栓術(PSE)の意義(脾摘vs PSE)

    • Author(s)
      谷合信彦, 吉田寛, 峯田章, 川野陽一, 真々田裕宏, 柿沼大輔, 内田英二, 田尻孝
    • Organizer
      第16回日本門脈圧亢進症学会総会
    • Place of Presentation
      福島
    • Related Report
      2008 Final Research Report
  • [Presentation] 当科における肝切除のクリニカルパスの変遷と功罪

    • Author(s)
      吉田寛, 真々田裕宏, 谷合信彦, 峯田章, 川野陽一, 水口義昭, 神田知洋, 内田英二
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 当科における肝細胞癌に対する肝切除術

    • Author(s)
      谷合信彦, 吉田寛, 峯田章, 川野陽一, 神田知洋, 内田英二, 田尻孝
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 当科における生体肝移植後血管IVR治療

    • Author(s)
      川野陽一, 谷合信彦, 吉田寛, 峯田章, 神田知洋, 平方敦史, 柿沼大輔, 秋丸琥甫, 田尻孝, 村田智, 汲田伸一郎, 内田英二
    • Organizer
      第71回日本臨床外科学会総会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Book] Regional Cancer therapy(Cancer Drug Discovery and Development)(Schlag PM, Stein U Edit)Humana Press2007

    • Author(s)
      Yoshida H
    • Publisher
      Regional therapy of pancreatic cancer
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2017-05-19  

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