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Analysis of liver regeneration and liver fibrosis focusing on mechanical stress

Research Project

Project/Area Number 19591606
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHyogo College of Medicine

Principal Investigator

IIMURO Yuji  Hyogo College of Medicine, 医学部, 准教授 (30252018)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Jirou  兵庫医科大学, 医学部, 教授 (90199373)
HIRANO Tadamichi  兵庫医科大学, 医学部, 講師 (90340968)
UYAMA Naoki  兵庫医科大学, 医学部, 助教 (70402873)
飯干 泰彦  兵庫医科大学, 医学部, 助教 (10340994)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords再生医学 / 細胞・組織 / 流体工学 / シミュレーション
Research Abstract

ヒトにおける切除後肝再生のメカニズムをメカニカルストレス応答の面から解析し、相対的門脈血流量の増加(相対的ストレス増加)が、領域別肝再生を制御している可能性が明らかとなった。また、肝臓におけるメカニカルストレス受容体の存在が具体的に示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Computational simulation of peri-operative change in portal biood flow dynamics in fibrotic and non-fibrotic human livers.2009

    • Author(s)
      Yuji Iimuro, et al.
    • Journal Title

      Hepatology International 3

      Pages: 176-176

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-uniform regional liver regeneration after hepatic surgery well correlates with computationally simulated increases in blood flow and pressure in portal branches.2008

    • Author(s)
      Yuji Iimuro, et al.
    • Journal Title

      Journal of Hepatology 48, 2, suppl

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-uniform increases in blood flow and pressure in porta branches after liver surgery assessed by computational flow dynamics simulation Well correlate with the regional liver regeneration2008

    • Author(s)
      Yuji Iimuro, et. al.
    • Journal Title

      Hepatology International 2

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection2007

    • Author(s)
      Yuji Iimuro, et. al.
    • Journal Title

      Hepatology 46,4,suppl

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Computational simulation of peri-operative change in portal blood flow dynamics in fibrotic and non-fibrotic human livers.2009

    • Author(s)
      Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Akito Yada, Jiro Fujimoto.
    • Organizer
      19^<th> Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Hong Kong, China
    • Related Report
      2008 Final Research Report
  • [Presentation] NON-UNIFORM REGIONAL LIVER REGENERATION AFTER HEPATIC SURGERY WELL CORRELATES WITH COMPUTATIONALLY SIMULATED INCREASES IN BLOOD FLOW AND PRESSURE IN PORTAL BRANCHES.2008

    • Author(s)
      Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
    • Organizer
      43rd Annual Meeting of the European Association for the Study of the Liver
    • Place of Presentation
      Milan, Italy
    • Related Report
      2008 Final Research Report
  • [Presentation] Non-uniform increases in blood flow and pressure in portal branches after liver surgery assessed by computational flow dynamics simulation well correlate with the regional liver regeneration.2008

    • Author(s)
      Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
    • Organizer
      18^<th> Conference of the Asian Pacific Association for the Study of the Liver
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2008 Final Research Report
  • [Presentation] Computational flow dynamics simulation of portal branches is useful for analyzing the mechanism of non-uniform regional liver regeneration after surgical resection.2007

    • Author(s)
      Yuji Iimuro, Shin-ichi Saito, Jun-ichi Yamanaka, Tadamichi Hirano, Nobukazu Kuroda, Toshihiro Okada, Takaaki Sugimoto, Yasukane Asano, Naoki Uyama, Yugo Uda, Jiro Fujimoto.
    • Organizer
      58^<th> Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, U.S.A.
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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