| Project/Area Number |
19591612
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
YOSHIDA Shigetoshi Chiba University, 医学部附属病院, 講師 (90334200)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHINO Ichiro 千葉大学, 大学院・医学研究院, 教授 (40281547)
WADA Hironobu 千葉大学, 医学部附属病院, 医員 (90514604)
安福 和弘 千葉大学, 医学部・附属病院, 助教 (60372356)
鈴木 秀海 千葉大学, 医学部・附属病院, 医員 (60422226)
関根 康雄 千葉大学, 大学院・医学研究院, 講師 (70312957)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SEKINE Yasuo 東京女子医科大学, 医学部, 准教授 (70312957)
YASUFUKU Kazuhiro University Health Network, Toronto, Canada, Division of Thoracic surgery, Toronto General Hospital, Assistant Professor (60372356)
SUZUKI Hidemi 東京女子医科大学, 医学部, 助教 (60422226)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 呼吸器外科学 / 移植・再生医療 / 外科 / 免疫学 / 細胞・組織 / 肺移植 / 免疫抑制 / 免疫寛容 / V型コラーゲン / 制御性T細胞 / 免疫抑制剤 |
|---|
| Research Abstract |
Oral administration of type V collagen [col(V)] plus low-dose cyclosporine (CsA) was abrogates rejection of fully MHC incompatible rat lung allograft. Col(V) plus CsA was down-regulated alloantigen-induced production of IFN-gamma and IL-17A and associated with alloantigen-induced expression of IL-10 in recipient T cells. These data demonstrate that col(V) enhances low-dose CsA-mediated immune suppression, and suggest a role for oral col(V) in immune modulation in lung transplantation.
|
