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Investigation of mechanism for neuronal recovery from cerebral strokeusing high field magnetic resonance imaging

Research Project

Project/Area Number 19591698
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionIwate Medical University

Principal Investigator

INOUE Takashi  Iwate Medical University, 医学部, 非常勤講師 (70326651)

Co-Investigator(Kenkyū-buntansha) OGAWA Akira  岩手医科大学, 学長 (10204067)
OGASAWARA Kuniaki  岩手医科大学, 医学部, 教授 (00305989)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsMRI / 神経画像診断学 / 脳卒中 / DTI / FAIR / 脳血管性障害 / 神経回復 / 定量化 / 画像診断 / 神経線維 / 脳血管障害
Research Abstract

本研究の目的は脳血管性障害における神経細胞・神経線維の障害程度を定量的に評価し、さらにその後の回復過程を画像化することである。
拡散テンソル画像を応用することにより神経線維を描出することが可能となった。また脳灌流画像においては、定量化を確立した。経時的評価を行うことにより、神経機能回復を客観的に評価する手法を確立した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (43 results)

All 2008 2007 Other

All Journal Article (27 results) (of which Peer Reviewed: 6 results) Presentation (13 results) Book (3 results)

  • [Journal Article] A method for visualization of brain neural pathway using critical points and target regions2008

    • Author(s)
      Doi A, Fujimura H, Nagano M, Inoue T, Ogawa A.
    • Journal Title

      Journal of Fluid Science and Technology 3

      Pages: 678-689

    • NAID

      130000077334

    • Related Report
      2008 Final Research Report
  • [Journal Article] Evaluation fo a neurosurgical planning system "Sei" In patients with brain tumor2008

    • Author(s)
      Fujiwara S, Kameda M, Inoue T, Matsuda K, Matsumura Y, Kanbara Y, Nishimoto H, Beppu T, Arai H, Saso M, Kashimura H, Ogasawara K, Ogawa A.
    • Journal Title

      JJSCAS 10

      Pages: 39-44

    • Related Report
      2008 Final Research Report
  • [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers2008

    • Author(s)
      Fujiwara S, Sasaki M, Kanbara Y, Inoue T, Hirooka R, Ogawa A
    • Journal Title

      Neuroradiology 50

      Pages: 131-136

    • Related Report
      2008 Final Research Report
  • [Journal Article] Magnetic resonance imaging in patients with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy2008

    • Author(s)
      Hirooka R, Ogasawara K, Sasaki M, Yamadate K, Kobayashi M, Suga Y, Yoshida K, Otawara Y, Inoue T, Ogawa A.
    • Journal Title

      J Neurosurg 108

      Pages: 1178-1183

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endarterectomy for mild cervical carotid artery stenosis in patients with ischemic stroke events refractory to medical treatment2008

    • Author(s)
      Kobayashi M, Ogasawara K, Inoue T, Saito H, Suga Y, Ogawa A.
    • Journal Title

      Neurol Med Chir(Tokyo) 48

      Pages: 211-215

    • Related Report
      2008 Final Research Report
  • [Journal Article] Magnetic resonance angiographic occlusion of the cervical carotid artery at 3 tesla : Its pitfall2008

    • Author(s)
      Mano Y, Shimizu H, Inoue T, Tominaga T.
    • Journal Title

      No Shinkei Geka 36

      Pages: 51-58

    • Related Report
      2008 Final Research Report
  • [Journal Article] Computer-assisted identification of the central sulcus in patients with brain tumors using mri2008

    • Author(s)
      Uwano I, Kameda M, Inoue T, Nishimoto H, Fujiwara S, Hirooka R, Ogawa A.
    • Journal Title

      J Magn Reson Imaging 27

      Pages: 1242-1249

    • Related Report
      2008 Final Research Report
  • [Journal Article] Computer-assisted identification of the central sulcus in patients with brain tumors using MRI2008

    • Author(s)
      Inoue T., 他
    • Journal Title

      J Magn Reson Imaging 27

      Pages: 1242-1249

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging in patients with cerebral hyperperfusion and cognitive impairment after carotid endarterectomy2008

    • Author(s)
      Inoue T., 他
    • Journal Title

      J Neurosurg 108

      Pages: 1178-1183

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers2008

    • Author(s)
      Inoue T., 他
    • Journal Title

      Neuroradiology 50

      Pages: 131-136

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary granulomatous angiitis of the central nervous system : Findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery2007

    • Author(s)
      Beppu T, Inoue T, Nishimoto H, Nakamura S, Nakazato Y, Ogasawara K, Ogawa A.
    • Journal Title

      Case report. J Neurosurg 107

      Pages: 873-877

    • Related Report
      2008 Final Research Report
  • [Journal Article] Preoperative imaging of superficially located glioma resection using short inversion-time inversion recovery images in high-field magnetic resonance imaging2007

    • Author(s)
      Beppu T, Inoue T, Nishimoto H, Ogasawara K, Ogawa A, Sasaki M.
    • Journal Title

      Clin Neurol Neurosurg

    • Related Report
      2008 Final Research Report
  • [Journal Article] Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers2007

    • Author(s)
      Fujiwara S, Sasaki M, Kanbara Y, Inoue T, Hirooka R, Ogawa A.
    • Journal Title

      Neuroradiology

    • Related Report
      2008 Final Research Report
  • [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 tesla2007

    • Author(s)
      Fujiwara S, Sasaki M, Kanbara Y, Matsumura Y, SHibata E, Inoue T, Nishimoto H, Ogawa A.
    • Journal Title

      Magn Reson Med Sci 6

      Pages: 127-132

    • NAID

      10019798069

    • Related Report
      2008 Final Research Report
  • [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 tesla2007

    • Author(s)
      Fujiwara S, Sasaki M, Kanbara Y, Matsumura Y, Shibata E, Inoue T, Nishimoto H, Ogawa A.
    • Journal Title

      Magn Reson Med Sci 6

      Pages: 127-132

    • NAID

      10019798069

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prediction of cerebral hyperperfusion after carotid endarterectomy using cerebral blood volume measured by perfusion-weighted mr imaging compared with single-photon emission ct2007

    • Author(s)
      Fukuda T, Ogasawara K, Kobayashi M, Komoribayashi N, Endo H, Inoue T, Kuzu Y, Nishimoto H, Terasaki K, Ogawa A.
    • Journal Title

      AJNR Am J Neuroradiol 28

      Pages: 737-742

    • Related Report
      2008 Final Research Report
  • [Journal Article] Diffusion tensor imaging for differentiation of recurrent brain tumor and radiation necrosis after radiotherapy--three case reports2007

    • Author(s)
      Kashimura H, Inoue T, Beppu T, Ogasawara K, Ogawa A.
    • Journal Title

      Clin Neurol Neurosurg 109

      Pages: 106-110

    • Related Report
      2008 Final Research Report
  • [Journal Article] Prediction of meningioma consistency using fractional anisotropy value measured by magnetic resonance imaging2007

    • Author(s)
      Kashimura H, Inoue T, Ogasawara K, Arai H, Otawara Y, Kanbara Y, Ogawa A.
    • Journal Title

      J Neurosurg 107

      Pages: 784-787

    • Related Report
      2008 Final Research Report
  • [Journal Article] Three-dimensional anisotropy contrast imaging of pontine gliomas : 2 case reports.2007

    • Author(s)
      Kashimura H, Inoue T, Ogasawara K, Beppu T, Kanbara Y, Ogawa A.
    • Journal Title

      Surg Neurol 67

      Pages: 156-159

    • Related Report
      2008 Final Research Report
  • [Journal Article] Urgent endarterectomy using pretreatment with free radical scavenger, edaravone, and early clamping of the parent arteries for cervical carotid artery stenosis with crescendo transient ischemic attacks caused by mobile thrombus and hemodynamic cerebral ischemia2007

    • Author(s)
      Kobayashi M, Ogasawara K, Inoue T, Saito H, Komoribayashi N, Suga Y, Ogawa A.
    • Journal Title

      Case report. Neurol Med Chir(Tokyo) 47

      Pages: 121-125

    • Related Report
      2008 Final Research Report
  • [Journal Article] Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke : The middle cerebral artery embolism local fibrinolytic intervention trial (melt) japan2007

    • Author(s)
      Ogawa A, Mori E, Minematsu K, Taki W, Takahashi A, Nemoto S, Miyamoto S, Sasaki M, Inoue T.
    • Journal Title

      Stroke 38

      Pages: 2633-2639

    • NAID

      40015989860

    • Related Report
      2008 Final Research Report
  • [Journal Article] Concentration of malondialdehyde-modified low-density lipoprotein in the jugular bulb during carotid endarterectomy correlates with development of postoperative cognitive impairment2007

    • Author(s)
      Saito H, Ogasawara K, Komoribayashi N, Kobayashi M, Inoue Otawara Y, Ogawa A
    • Journal Title

      Neurosurgery 60

      Pages: 1067-1073

    • Related Report
      2008 Final Research Report
  • [Journal Article] proximal ligation of the parent artery for symptomatic tandem stenosis of the extradural internal carotid artery : A case report2007

    • Author(s)
      Suga Y, Ogasawara K, Saito H, Kobayashi M, Inoue T, Kondo R, Ogawa A.
    • Journal Title

      No Shinkei Geka 35

      Pages: 787-791

    • Related Report
      2008 Final Research Report
  • [Journal Article] Preoperative cerebral hemodynamic impairment and reactive oxygen species produced during carotid endarterectomy correlate with development of postoperative cerebral hyperperfusion2007

    • Author(s)
      Suga Y, Ogasawara K, Saito H, Komoribayashi N, Kobayashi M, Inoue T, Otawara Y, Ogawa A.
    • Journal Title

      Stroke 38

      Pages: 2712-2717

    • Related Report
      2008 Final Research Report
  • [Journal Article] Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial(MELT)Japan2007

    • Author(s)
      Inoue T, 他
    • Journal Title

      Stroke 38

      Pages: 2633-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of cerebral metabolic change in patients undergoing carotid endarterec tomy using magnetic resonance spectroscopy2007

    • Author(s)
      Inoue T, 他
    • Journal Title

      Proceedings of ISMRM

      Pages: 448-448

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improved geometric distortion in coronal diffusion-weighted and diffusion tensor imaging using a whole-brain isotropic-voxel acquisition technique at 3 Tesla2007

    • Author(s)
      Inoue T, 他
    • Journal Title

      Magn Reson Med Sci. 6

      Pages: 127-32

    • NAID

      10019798069

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 3T MRIによる脳温測定2008

    • Author(s)
      井上敬他
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      旭川
    • Related Report
      2008 Final Research Report
  • [Presentation] MRIによる脳温測定の可能性2008

    • Author(s)
      井上敬他
    • Organizer
      AVMによる検討
    • Place of Presentation
      盛岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 高磁場2008

    • Author(s)
      井上敬他
    • Organizer
      MRIによる血管評価
    • Place of Presentation
      0月
    • Related Report
      2008 Final Research Report
  • [Presentation] 3.0Tesla2008

    • Author(s)
      井上敬
    • Organizer
      MRIによる非侵襲脳循環代謝測定法の臨床応用
    • Place of Presentation
      松山
    • Related Report
      2008 Final Research Report
  • [Presentation] MELT Japanからみた局所線溶療法の将来予測2008

    • Author(s)
      井上敬他
    • Organizer
      脳神経外科コングレス
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 急性期脳卒中のMRI診断2008

    • Author(s)
      井上敬
    • Organizer
      脳卒中学会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] 3T MRI による非侵襲的脳循環評価2008

    • Author(s)
      井上敬
    • Organizer
      脳神経CI学会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] MRIによるOEF評価2008

    • Author(s)
      井上敬他
    • Organizer
      脳卒中学会
    • Place of Presentation
      京都
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessment of cerebral metabolic change in patients undergoing carotid endarterectomy using magnetic resonance spectroscopy2007

    • Author(s)
      Inoue T, Ogasawara K, Kobayashi M, Nishimoto H, Hirooka R, Kanbara Y, Matsumura Y, Fujiwara S, Ogawa A
    • Organizer
      Presented at annual meeting International Society of Magnetic Resonance in Medicine
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] 局所線溶療法の現状-tPA時代を迎えて2007

    • Author(s)
      井上敬
    • Organizer
      Brain heart attach forum
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳梗塞超急性期局所線溶療法の有効性-MELT-Japan2007

    • Author(s)
      井上敬、小川彰、MELT Japan Study Group
    • Organizer
      脳卒中学会
    • Place of Presentation
      福岡
    • Related Report
      2008 Final Research Report
  • [Presentation] 3TMRIで神経外傷がどこまで分かるか2007

    • Author(s)
      井上敬
    • Organizer
      神経外傷学会
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] Assessment of cerebral metabolic change in patients undergoing carotid endarterec,.tomy using magnefic resonance spectroscopy2007

    • Author(s)
      Inoue T, 他
    • Organizer
      ISMRM
    • Place of Presentation
      Berlin
    • Related Report
      2007 Annual Research Report
  • [Book] 脳卒中の画像診断Early CT sign2008

    • Author(s)
      井上敬他
    • Publisher
      永井書店
    • Related Report
      2008 Final Research Report
  • [Book] 脳卒中の画像診断Early CT sign2008

    • Author(s)
      井上敬, 他
    • Total Pages
      572
    • Publisher
      永井書店
    • Related Report
      2008 Annual Research Report
  • [Book] 大規模臨床試験-循環・代謝系

    • Author(s)
      井上 敬, 他
    • Publisher
      日本臨床(印刷中)
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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