Novel therapeutic strategy by inhibition of multiple signal transduction pathways for malignant gliomas
Project/Area Number |
19591701
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
|
Research Institution | Kyorin University |
Principal Investigator |
NAGANE Motoo Kyorin University, 医学部, 准教授 (60327468)
|
Co-Investigator(Kenkyū-buntansha) |
SHIOKAWA Yoshiaki 杏林大学, 医学部, 教授 (20245450)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | glioma / 分子標的治療 / シグナル伝達 / アポトーシス / Akt / EGFR / モノクローナル抗体 |
Research Abstract |
Malignant glioma cells harbor tumor-specific genetic alterations which often activate intracellular signaling pathways, thereby conferring tumor initiation, malignant transformation, and resistance to conventional therapies. Thus, inhibition of such pathways could endow therapeutic benefits. Here we targeted the pathways of PDGFR and/or EGFR in combination with antitumor drugs, resulting in inactivation of their downstream signalings and suppression of tumor growth in human glioma cell lines.
|
Report
(4 results)
Research Products
(78 results)