Antineoplastic effect of octacalcium phosphate with osteoconductive characteristics
| Project/Area Number |
19591713
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
HATORI Masahito Tohoku University, 大学院・医学研究科, 准教授 (70208552)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948)
ITOI Eiji 東北大学, 大学院・医学系研究科, 教授 (80193465)
HOSAKA Masami 東北大学, 大学院・医学系研究科, 助教 (90302124)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 骨・軟部腫瘍学 / 人工骨 / 骨軟部腫瘍 / 骨再生 / リン酸カルシウム |
|---|
| Research Abstract |
The purpose of this study is to evaluate antineoplastic effect of octacalcium phosphate(OCP) with osteoconductive characteristics. EES1, newly-established cell line of Ewing's sarcoma were cultured and evaluated for its growth potential on OCP-coated and hydrolyzate(HL)-coated plates and control.As compared with the control, EES1 growth was suppressed on both OCP-coated and HL-coated plates. C2C12, mouse myoblast cell line was also suppressed on OCP-coated and HL-coated plates. The present study suggests potential application of OCP with various kinds of crystallinity as a bone substitute for the treatment of bone and soft tissue tumors.
|
Report
(4 results)
Research Products
(16 results)
