cAMP administration on motor cortex with NT-3 secreted BMSC trarlsplantation after spinal cord injury
| Project/Area Number |
19591715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
ATSUSHI Murata Chiba University, 医学部・附属病院, 准教授 (20344997)
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| Co-Investigator(Kenkyū-buntansha) |
KAZUKI Kuniyoshi 千葉大学, 医学部・附属病院, 助教 (40375788)
MASASHI Yamazaki 千葉大学, 大学院・医学研究院, 准教授 (50281712)
AKIHIKO Okawa 千葉大学, 医学部・附属病院, 講師 (30312945)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脊髄損傷 / cAMP / BMSC / BBB score / シロスタゾール / phosphodiesterase III / CREB / 大脳皮質 / hos hodiesterase III |
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| Research Abstract |
脊髄損傷の臨床応用を考え、cAMPの濃度を保つことによるフォスフォジエステラーゼ阻害薬のシロスタゾール投与による治療法を考えた。ラット脊髄損傷急性期、慢性期、予防的投与の3実験を行ったが、いずれも有意差が得られなかった。これは薬剤単独では脊髄損傷の治癒は困難であることを示唆した。
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice2007
Author(s)
Nishio Y, Koda M, Canada T, Someya Y, Kadota R, Mannoji C, Miyashita T, Okada S, Okawa A, Moriya H, Yamazaki M
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Journal Title
J Neuropathol Exp Neurol 66(8)
Pages: 724-31
Related Report
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[Journal Article] Adenovirus vector-mediated ex vivo gene transfer of brain-derived neurotrophic factor to bone marrow stromal cells promotes axonal regeneration after transplantation in completely transected adult rat spinal cord2007
Author(s)
Koda M, Kamada T, Hashimoto M, Murakami M, Shirasawa H, Sakao S, Ino H, Yoshinaga K, Koshizuka S, Moriya H, Yamazaki M
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Journal Title
Eur Spine J(Epub ahead of print) Sep 21
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