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Molecular therapy for bone and soft tissue sarcomas targeting a new cancer-associated protein, C7orf24

Research Project

Project/Area Number 19591719
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyoto University

Principal Investigator

NAKAYAMA Tomitaka  Kyoto University, 医学研究科, 講師 (80335273)

Co-Investigator(Kenkyū-buntansha) 戸口田 淳也  京都大学, 再生医科学研究所, 教授 (40273502)
Co-Investigator(Renkei-kenkyūsha) TOGUCHIDA Junya  京都大学, 再生医科学研究所, 教授 (40273502)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsC7orf24 / 骨軟部肉腫 / 分子標的治療
Research Abstract

膀胱癌の治療標的分子として同定されたC7orf24の骨肉腫における意義を明らかにすることを目的とした. C7orf24は骨肉腫腫瘍組織で高発現していたが、発現導入実験では、明らかな表現型を誘導できず、発現抑制実験では特定の細胞株では著しい形態変化を導いたが、普遍的な現象ではなかった. アポトーシス等の細胞死との関連も検出されず、C7orf24の骨肉腫における治療標的としての明確な意義を示す結果は得られなかった.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2009 2008 2007 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (32 results)

  • [Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors2009

    • Author(s)
      Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J.
    • Journal Title

      Cancer Sci 100(3)

      Pages: 405-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of ERK activation in human osteosarcoma cell resistance to the HDAC inhibitor FK2282009

    • Author(s)
      Matsubara H, Watanabe M, Imai T, Yui Y, Mizushima Y, Hiraumi Y, Kamitsuji Y, Watanabe KI, Nishijo K, Toguchida J, Nakahata T, Adachi S.
    • Journal Title

      J Pharmacol Exp Ther 328(3)

      Pages: 839-48

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma2009

    • Author(s)
      Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T.
    • Journal Title

      Oncogene 28(8)

      Pages: 1110-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation2008

    • Author(s)
      Watanabe M, Adachi S, Matsubara H, Imai T, Yui Y, Mizushima Y, Hiraumi Y, Watanabe KI, Kamitsuji Y, Toyokuni SY, Hosoi H, Sugimoto T, Toguchida J, Nakahata T.
    • Journal Title

      Int J Cancer 124(1)

      Pages: 55-67

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities2008

    • Author(s)
      Chen F, Miyahara R, Bando T, Okubo K, Watanabe K, Nakayama T, Toguchida J, Date H.
    • Journal Title

      Eur J Cardiothorac Surg 34(6)

      Pages: 1235-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas : Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study2008

    • Author(s)
      Ueda T, Naka N, Araki N, Ishii T, Tsuchiya H, Yoshikawa H, Mochizuki K, Tsuboyama T, Toguchida J, Ozaki T, Murata H, Kudawara I, Tanaka K, Iwamoto Y, Yazawa Y, Kushida K, Otsuka T, Sato K.
    • Journal Title

      J Orthop Sci 13(4)

      Pages: 304-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal differentiation of synovial sarcoma and its therapeutic application2008

    • Author(s)
      Ishibe T, Nakayama T, Aoyama T, Nakamura T, Toguchida J.
    • Journal Title

      Clin Orthop Rel Res 466(9)

      Pages: 2147-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural course of desmoid-type fibromatosis2008

    • Author(s)
      Nakayama T, Tsuboyama T, Toguchida J, Hosaka T, Nakamura T.
    • Journal Title

      J Orthop Sci 13(1)

      Pages: 51-5

    • NAID

      10024138969

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD102008

    • Author(s)
      Furukawa C, Hanaoka H, Nagayama S, Tsunoda T, Toguchida J, Endo K, Nakamura Y, Katagiri T.
    • Journal Title

      Cancer Sci 99(2)

      Pages: 432-40

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma : A multi-institutional retrospective analysis in Japan2008

    • Author(s)
      Takenaka S, Ueda T, Naka N, Araki N, Hashimoto N, Myoui A, Ozaki T, Nakayama T, Toguchida J, Tanaka K, Iwamoto Y, Matsumine A, Uchida A, Ieguchi M, Kaya M, Wada T.
    • Journal Title

      Oncology Report 19(2)

      Pages: 467-476

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma : A multi-institutional retrospective analysis in Japan2008

    • Author(s)
      Takenaka S, et al.
    • Journal Title

      Oncology Report 19

      Pages: 467-476

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal differentiation of synovial sarcoma and its therapeutic application2008

    • Author(s)
      Ishibe T, et al.
    • Journal Title

      Clin Orthop Rel Res 466

      Pages: 2147-2155

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas : Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study2008

    • Author(s)
      Ueda T, et al.
    • Journal Title

      J Orthop Sci 13

      Pages: 304-312

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities2008

    • Author(s)
      Chen F, et al.
    • Journal Title

      Eur J Cardiothorac Surg 34

      Pages: 1235-1239

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma2007

    • Author(s)
      Kageyama S, Iwaki H, Inoue H, Isono T, Yuasa T, Nogawa M, Maekawa T, Ueda M, Kajita Y, Ogawa O, Toguchida, J, Yoshiki T.
    • Journal Title

      Proteomics Clin Appl 1

      Pages: 192-199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro transformation of mesenchymal stem cells by oncogenic H-rasVal12.2007

    • Author(s)
      Shima Y, et. al.
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 60-66

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel tumor-related protein, C7orf24, identified by proteome differential display of bladder urothelial carcinoma.2007

    • Author(s)
      Kageyama S, et. al.
    • Journal Title

      Proteomics Clin Appl 1

      Pages: 192-199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of a Ewing Sarcoma Family Tumor in the Urinary Bladder After Treatment for Acute Lymphoblastic Leukemia.2007

    • Author(s)
      Osone S, et. al.
    • Journal Title

      J Pediatr Hematol Oncol 29

      Pages: 841-844

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic implication of SYT-SSX fusion type in synovial sarcoma: Amulti-institutional retrospective analysis in Japan.2007

    • Author(s)
      Takenaka S, et. al.
    • Journal Title

      Oncology Report 19

      Pages: 467-476

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.2007

    • Author(s)
      Fukukawa C, et. al.
    • Journal Title

      Cancer Sci 99

      Pages: 432-440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular genetics of sarcomas : Applications to diagnosses and theray

    • Author(s)
      Toguchida J, Nakayama T.
    • Journal Title

      Cancer Sci (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 網羅的解析からの骨軟部腫瘍へのアプローチ2008

    • Author(s)
      戸口田淳也
    • Organizer
      第2回東京医科歯科大学硬組織疾患ゲノムセンターシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 体外処理骨を用いた悪性骨腫瘍切除後再建2008

    • Author(s)
      中山富貴、戸口田淳也、他
    • Organizer
      第17回小児固形腫瘍研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 肉腫における転移関連新規因子C7059の機能解析2008

    • Author(s)
      布留守敏、中山富貴、戸口田淳也、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 肉腫において組織幹細胞としての特質は癌幹細胞としての特質に連関するものか2008

    • Author(s)
      戸口田淳也、中山富貴、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 肉腫におけるras遺伝子の変異解析2008

    • Author(s)
      金永輝、中山富貴、戸口田淳也、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 大腸癌にて高発現している新規遺伝子の免疫組織化学染色による発現解析2008

    • Author(s)
      長山聡、戸口田淳也、他
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 肉腫転移関連因子C7059の機能解析2008

    • Author(s)
      布留守敏、中山富貴、戸口田淳也、他
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 肉腫転移関連因子C70059の機能解析2008

    • Author(s)
      布留守敏, 他.
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 分化誘導プロファイルを用いた肉腫起源細胞へのアプローチ2008

    • Author(s)
      青山朋樹、中山富貴、戸口田淳也、他
    • Organizer
      第41回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 多発骨転移を生じた粘液型脂肪肉腫の3例2008

    • Author(s)
      中山富貴, 他.
    • Organizer
      第41回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 遺伝子発現プロファイルからみた骨・軟部腫瘍の起源・分類・診断2008

    • Author(s)
      戸口田淳也
    • Organizer
      第41回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 肉腫転移関連因子C7059の機能解析および治療標的としての可能性の探索2008

    • Author(s)
      布留守敏、中山富貴、戸口田淳也、他
    • Organizer
      第41回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-17
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 大腿骨遠位部骨腫瘍に対する非蝶番型人工膝関節の使用経験2008

    • Author(s)
      仲俣岳晴, 他.
    • Organizer
      第41回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-07-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肉腫幹細胞と組織幹細胞の接点2008

    • Author(s)
      戸口田淳也
    • Organizer
      治療開発を目指した最前線セミナー2Cancer Stem Cell~がん幹細胞をターゲットとした治療の開発に向けて~
    • Place of Presentation
      東京
    • Year and Date
      2008-06-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌幹細胞探索のための細胞イメージングの可能性2008

    • Author(s)
      戸口田淳也
    • Organizer
      第47回日本生体医工学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-05-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Snail is negative regulator controlling the construction of epithelial structures in SS2007

    • Author(s)
      Kohno T, Nakayama T, Toguchida J, et.al.
    • Organizer
      第13回(CTOS)
    • Place of Presentation
      Seattle
    • Year and Date
      2007-11-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Multidirectional differentiation property like mesenchymal stem cells of osteosarcomas in vitro and in vivo2007

    • Author(s)
      Otsuka S, Nakayama T, Toguchida J, et.al.
    • Organizer
      第13回(CTOS)
    • Place of Presentation
      Seattle
    • Year and Date
      2007-11-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Isolation and functional analysis of a novel protein associated with the distant metastases of spindle cell sarcomas2007

    • Author(s)
      Furu M, Nakayama T, Toguchida J, et.al.
    • Organizer
      第13回(CTOS)
    • Place of Presentation
      Seattle
    • Year and Date
      2007-11-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Isolation and functional analysis of a novel protein associated with the distant metastases of spindle cell sarcomas.2007

    • Author(s)
      Moritoshi Furu, et. al.
    • Organizer
      13th Annual Meeting of Connective Tissue Oncology Society
    • Place of Presentation
      Seattle
    • Year and Date
      2007-11-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] 滑膜肉腫の上皮構造形成におけるCLD7、ELF3およびSnailの関連性について2007

    • Author(s)
      光野芳樹、中山富貴、戸口田淳也、他
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 紡錘形軟部肉腫における生命予後因子C7059と細胞浸潤能の解析2007

    • Author(s)
      布留守敏、戸口田淳也、他
    • Organizer
      第22回日本整形外科学会基礎学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Snail is negative regulator controlling the construction of epithelial structures in SS2007

    • Author(s)
      Kohno Y, Nakayama T, Toguchida J, et.al.
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Isolation and functional analysis of a novel protein associated with the distant metastases of spindle cell sarcomas2007

    • Author(s)
      Furu M, Nakayama T, Toguchida J, et.al.
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Some osteosarcomas have multidirectional differentiation potential like mesenchymal stem cells in vitro and in vivo2007

    • Author(s)
      Otsuka S, Nakayama T, Toguchida J, et.al.
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] イットリウム90-抗FZD10モノクローナル抗体による滑膜肉腫抗体治療の検討2007

    • Author(s)
      福川千香子、戸口田淳也、他
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Relationship among CLDN7, ELF3, and Snail in the formation of the epithelial structures in synovial sarcomas2007

    • Author(s)
      Kohno Y, Nakayama T, Toguchida J, et.al.
    • Organizer
      第5回SIROT
    • Place of Presentation
      Marrakech
    • Year and Date
      2007-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Isolation and functional analysis of a novel protein identified as the prognostic factor in spindle cell sarcomas2007

    • Author(s)
      Furu M, Nakayama T, Toguchida J, et.al.
    • Organizer
      第5回SIROT
    • Place of Presentation
      Marrakech
    • Year and Date
      2007-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] 滑膜肉腫の上皮構造形成におけるCLDN7、ELF3およびSnailの関連性について2007

    • Author(s)
      光野芳樹、中山富貴、戸口田淳也、他
    • Organizer
      第40回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2007-07-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 培養骨肉腫細胞のもつ間葉系幹細胞様の多分化能2007

    • Author(s)
      大塚聖視、中山富貴、戸口田淳也、他
    • Organizer
      第40回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2007-07-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 紡錘形軟部肉腫における生命予後関連因子としての新規遺伝子C7059の単離と機能解析2007

    • Author(s)
      布留守敏、中山富貴、戸口田淳也、他
    • Organizer
      第40回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2007-07-12
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 網羅的遺伝子発現解析からの紡錘形細胞肉腫における生命予後関連因子の単離2007

    • Author(s)
      戸口田淳也、中山富貴、他
    • Organizer
      第40回日本整形外科学会骨軟部腫瘍学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2007-07-12
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Some osteosarcomas have multidirectional differentiation potential suggested that these cells may derive directly from mesenchymal stem cells2007

    • Author(s)
      Otsuka S, Nakayama T, Toguchida J, et.al.
    • Organizer
      第5回ISSCR
    • Place of Presentation
      Cairns
    • Year and Date
      2007-06-19
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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