Biologic manipulation for pain control in degenerative disc disease

• Project/Area Number: 19591731
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: MAMORU Kawakami Wakayama Medical University, 医学部医学科, 教授 (20195051)
• Co-Investigator(Kenkyū-buntansha): NAKANE Yasuhiro 和歌山県立医科大学, 医学部・医学科, 助教 (40382345) ; 南出 晃人 和歌山県立医科大学, 医学部, 講師
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 脊椎脊髄病学 / 椎間板 / 疼痛 / 再生 / 腰痛モデル / 骨形成蛋白 / サイトカイン / 痛覚過敏 / 変性

Research Abstract

椎間板性疼痛を評価し得る椎間板変性モデルをラット尾椎で作成した。このモデルでは椎間板変性に伴いコラーゲン、アグレカン、プロテオグリカンの減少が認められ、疼痛行動と関連してインターロイキン-1β、tumor necrosis factor-αの増加がみられた。骨形成蛋白などを椎間板に注入したラットでは尾部に鎮痛効果が得られ、これらのサイトカインの発現減少と細胞外基質の産生亢進が観察された。変性椎間板を痛みなく再生させる安全な生物学的治療法が確立可能である

Research Products

• [Journal Article] Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs (2007)
  • Author(s): Susan Chubinskaya, Mamoru Kawakami, Lev Rappoport, Takuji Matsumoto, Nami Migita,David C Rueger
  • Journal Title: J Orthopaedic Research 26 Pages: 517-30
• [Journal Article] Safety of epidural administration of Osteogenic Protein-1 (OP-1/BMP-7) : Behavioral andmacroscopic observation (2007)
  • Author(s): Mamoru Kawakami, Hiroshi Hashizume, Takuji Matsumoto, Yoshio Enyo, MotohiroOkada, Munehito Yoshida, Susan Chubinskaya
  • Journal Title: Spine 32 Pages: 1388-93
• [Journal Article] Anti-catabolic effect of OP-1 in chronically compressed intervertebral discs (2007)
  • Author(s): Susan Chubinskaya, Mamoru Kawakami, et. al.
  • Journal Title: J Orthopaedic Research 26 Pages: 517-530
  • Peer Reviewed
• [Journal Article] Safety of epidural administration of Osteogenic Protein-1(OP-1/BMP-7):Behavioral and macroscopic observation (2007)
  • Author(s): Mamoru Kawakami, et. al.
  • Journal Title: Spine 32 Pages: 1388-1393
  • Peer Reviewed
• [Presentation] A possible mechanism of pain abolished bybiological manipulation of OP-1 for degenerativeintervertebral disc (2008)
  • Author(s): Mamoru Kawakami, Takuji Matsumoto, Hiroshi Hashuzume, Susan Chubinskaya
  • Organizer: World Forum for Spine Research The Intervertebral Disc First JapaneseMeeting
  • Place of Presentation: Kyoto
• [Book] Chapter 17. Biological manipulation for degenerative discdisease utilizing intradiscal osteogenic Protein-1(OP-1/BMP-7) injection - An animal study. In : Spinal Reconstuction : Clinical Examples ofApplied Basic Science, Biomechanics, and Engineering(Kai-Uwe Lewandrowski, Michael J.Yaszemski, Iain H. Kalfas, Paul Park, Robert F.McLain and Debra J. Trantolo eds) (2007)
  • Author(s): Mamoru Kawakami, Takuji Matsumoto, Hiroshi Hashizume, Munehito Yoshida, KoichiKuribayashi, Susan Chubinskaya
  • Publisher: Informa Healthcare, New York, USA
• [Book] Spinal Reconstuction:Clinical Examples of Applied Basic Science, Biomechanics, and Engineering (2007)
  • Author(s): Mamoru Kawakami, et. al.
  • Publisher: Informa Healthcare