How dose the alteration in mechanical load due to change of alignment influence articular cartilage of knee joint
| Project/Area Number |
19591733
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
URABE Ken Kitasato University, 医学部, 准教授 (90284489)
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| Co-Investigator(Kenkyū-buntansha) |
JINGUSHI Seiya 九州大学, 医学部, 准教授 (80235829)
NARUSE Kouji 北里大学, 医学部, 講師 (60276087)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 四肢機能再建学 / 変形性膝疾患 / アライメント / 骨切り術 / 変形性膝関節症 |
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| Research Abstract |
It is very important to understand how the alteration in mechanical load due to change of alignment influences articular cartilage of knee joint. In this study we could not establish the animal model that had an onset of osteoarthritis (OA) of knee joint by change of knee alignment. However, we found that OA changes of the patellofemoral joint in STR/OrtCrlj mice that spontaneously developed knee OA may be caused by internal tibial torsion.
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Report
(4 results)
Research Products
(7 results)
