How dose the alteration in mechanical load due to change of alignment influence articular cartilage of knee joint

• Project/Area Number: 19591733
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kitasato University
• Principal Investigator: URABE Ken Kitasato University, 医学部, 准教授 (90284489)
• Co-Investigator(Kenkyū-buntansha): JINGUSHI Seiya 九州大学, 医学部, 准教授 (80235829) ; NARUSE Kouji 北里大学, 医学部, 講師 (60276087)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 四肢機能再建学 / 変形性膝疾患 / アライメント / 骨切り術 / 変形性膝関節症

Research Abstract

It is very important to understand how the alteration in mechanical load due to change of alignment influences articular cartilage of knee joint. In this study we could not establish the animal model that had an onset of osteoarthritis (OA) of knee joint by change of knee alignment. However, we found that OA changes of the patellofemoral joint in STR/OrtCrlj mice that spontaneously developed knee OA may be caused by internal tibial torsion.

Research Products

• [Journal Article] Urabe KOsteoarthritic changes of the patellofemoral joint in STR/OrtCrlj mice are the earliest detectable changes and may be caused by internal tibial torsion. (2009)
  • Author(s): Naruse K, Jiang SX, Uchida K, Kozai Y, Minehara H, Mikuni-Takagaki Y, Kashima I, Itoman M.
  • Journal Title: Connect Tissue Res 50(4) Pages: 243-55
  • Peer Reviewed
• [Journal Article] Hyperlipidemia and hyperinsulinemia in the spontaneous osteoarthritis mouse model (2009)
  • Author(s): Uchida K, Urabe K, Naruse K, Ogawa Z, Mabuchi K, Itoman M.
  • Journal Title: STR/Ort. Exp Anim 58(2) Pages: 181-7
  • Peer Reviewed
• [Journal Article] Osteoarthritic changes of the patellofemoral joint in STR/OrtCrlj mice are the earliest detectable changes and may be caused by internal tibial torsion. (2009)
  • Author(s): Naruse K, Urabe K
  • Journal Title: Connect Tissue Res. 50 Pages: 243-255
  • Peer Reviewed
• [Journal Article] Hyperlipidemia and hyperinsulinemia in the spontaneous osteo arthritis mouse model, STR/Ort. (2009)
  • Author(s): Uchida K, Urabe K
  • Journal Title: Exp Anim 50 Pages: 181-187
  • Peer Reviewed
• [Journal Article] 糸満盛憲変形性膝関節症を自然発症するSTR/OrtCrljマウスの軟X線像による形態学的検討および組織学的検討 (2008)
  • Author(s): 成瀬康治、占部憲
  • Journal Title: 別冊整形外科 N0.53 Pages: 14-18
  • Peer Reviewed
• [Presentation] STR/OrtCrljの変形性変化は、膝蓋大腿関節に最も早期に認められ、その原因は脛骨内捻に起因する (2008)
  • Author(s): 成瀬康治
  • Organizer: 第21回日本軟骨代謝学会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-21
• [Presentation] Abnormal tibial torsion may cause an earliest detectable deformity in STR/OrtCrlj osteoarthritis mouse model, Orthopaedic research societies (2007)
  • Author(s): Naruse K
  • Organizer: 6th combined meeting
  • Place of Presentation: Hawaii
  • Year and Date: 2007-10-27