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Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.

Research Project

Project/Area Number 19591749
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

HIRANO Fuminori  Asahikawa Medical College, 医学部, 講師 (60250552)

Co-Investigator(Kenkyū-buntansha) MAKINO Yuichi  旭川医科大学, 医学部, 講師 (90345033)
OKAMOTO Kensaku  旭川医科大学, 医学部, 助教 (80396879)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsリウマチ病学 / 関節リウマチ / 滑膜炎 / 転写因子 / NF-κB / シグナル伝達 / 免疫学 / 核酸 / 臨床 / 発現制御
Research Abstract

Rheumatoid arthritis (RA) is an autoimmune disease to cause joint and cartilage destructions by the inflammation of a sustained synovium. NF-κB is a transcription factor and plays a pivotal role in regulating synovitis in RA. In unstimulated cells, NF-κB binds to inhibitory molecules IκBs and exists in cytoplasm. Especially, IκBβ2 has the strongest inhibitory effect against NF-κB activation in IκBs. Therefore, in this study, we found abnormal expression of the IκBβ2 protein which could restrain NF-κB and elucidated that the abnormal expresion of the IκBβ2 protein was due to produce RNA-binding protein and microRNA expression. The new RA treatment of the few type may be developed conventionally in future by these results of research.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2010 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 4 results) Presentation (16 results) Book (2 results)

  • [Journal Article] 呼吸器合併症のスクリーニング検査について2010

    • Author(s)
      平野史倫
    • Journal Title

      ファーマナビゲーターシリーズ「リウマチ~生物学的製剤編~」 (印刷中)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity2009

    • Author(s)
      Takahashi K, Hirano F, Matsumoto K, Aso K, Haneda M.
    • Journal Title

      Pancreas 38(1)

      Pages: 49-57

    • NAID

      10025227995

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferation by down-regulating cyclin D1 transcriptional activity.2009

    • Author(s)
      Kenji Takahashi
    • Journal Title

      Pancreas 38(1)

      Pages: 49-57

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床症状-腺外症状-甲状腺病変2009

    • Author(s)
      平野史倫
    • Journal Title

      シェーグレン症候群の診断と治療マニュアル

      Pages: 132-137

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Homeobox gene CDX2 inhibits human pancreatic cancer cell proliferati on by down-re¢ulatins cvclin D1 transcrintional activity2009

    • Author(s)
      Kenji Takahashi
    • Journal Title

      Pancreas 38(1)

      Pages: 49-57

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集「禁煙を科学する」喫煙による内分泌代謝機能への影響2008

    • Author(s)
      平野史倫, 羽田勝計
    • Journal Title

      綜合臨床 57(8)

      Pages: 2149-2152

    • Related Report
      2009 Final Research Report
  • [Journal Article] 禁煙を科学する「喫煙による内分泌代謝機能への影響」2008

    • Author(s)
      平野史倫
    • Journal Title

      綜合臨床 57(8)

      Pages: 2149-2152

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 特集「古くて新しい胆汁酸 最近の話題」胆汁酸による転写因子活性化機構2007

    • Author(s)
      平野史倫
    • Journal Title

      臨床化学 36(3)

      Pages: 205-214

    • Related Report
      2009 Final Research Report
  • [Journal Article] Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1) : a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells2007

    • Author(s)
      Makino Y, Uenishi R, Okamoto K, Isoe T, Hosono O, Tanaka H, Kanopka A, Poellinger L, Haneda M, Morimoto C.
    • Journal Title

      J Biol Chem 282(19)

      Pages: 14073-14082

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] Glucocorticoid and tumor necrosis factor-α additively up-regulate RANKL mRNA expression in human osteoblast-like cells : Influence of glucocorticoid treatment on generalized osteoporosis in rheumatoid arthritis2009

    • Author(s)
      F. Hirano
    • Organizer
      2^<nd> Joint Meeting of International Bone & Mineral Society
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] エタネルセプト効果減弱関節リウマチ患者における白血球除去療法の有効性とその作用機序に関する検討2009

    • Author(s)
      平野史倫
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Effectiveness of leukocytapheresis for etanercept-resistant rheumatoid arthritis : Decreased responsiveness to lipopolysaccharide-induced stimulation of inflammatory cytokines in peripheral blood mononuclear cells2009

    • Author(s)
      F. Hirano
    • Organizer
      Annual European Congress of Rheumatology (EULAR2009)
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Final Research Report
  • [Presentation] 膠原病における甲状腺自己抗体の出現頻度に関する検討2009

    • Author(s)
      平野史倫
    • Organizer
      第52回日本甲状腺学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Effectiveness of leukocytapheresis for etanercept-resistant rheumatoid arthritis : Decreased responsiveness to lipopolysaccharide-induced stimulation of inflammatory cytokines in peripheral blood mononuclear cells.2009

    • Author(s)
      平野史倫
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2009 Annual Research Report
  • [Presentation] Glucocorticoid and TNF-α additively up-regulate RANKL mRNA expression in human osteoblast-like cells : Influence of glucocorticoid treatment on generalized osteoporosis in rheumatoid arthritis.2009

    • Author(s)
      Fuminori Hirano
    • Organizer
      Annual Meeting of, the International Bone & Min eral Society (IBMS2009)
    • Place of Presentation
      Sydney, AUSTRALIA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parathyroid hormone and glucocorticoid cooperatively induce RANKL mRNA expression in osteoblasts through different mechanisms2008

    • Author(s)
      F. Hirano
    • Organizer
      10th European Congress of Endocrinology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2009 Final Research Report
  • [Presentation] RA線維芽滑膜細胞におけるTNFαとステロイドによるRANKL発現調節機構に関する検討2008

    • Author(s)
      平野史倫
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Dexamethasone additively increases TNFα-induced RANKL mRNA expression in RA fibroblast-like svnoviocvtes2008

    • Author(s)
      Fulninori Hirano
    • Organizer
      The 52^<st> Annual Scientific Meeting of the Japan College of Rheumatology
    • Place of Presentation
      Sapporo, JAPAN
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parathyroid hormone and glucocorticoid cooperatively induce RANKL mRNA expression in osteoblasts through different mechanisms2008

    • Author(s)
      Fuminori Hirano
    • Organizer
      10th European Congress of Endocrinology
    • Place of Presentation
      Berlin, GERMANY
    • Related Report
      2008 Annual Research Report
  • [Presentation] Regulation of RANKL Expression by Glucocorticoid in Human Osteoblast-like Cells2007

    • Author(s)
      F. Hirano
    • Organizer
      29th Annual Meeting of American Society for Bone and Mineral Research
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] The homeodomain transcription factor CDX2 inhibits human pancreatic cancer cell proloferation by repressing cyclin D1 transcription2007

    • Author(s)
      K. Takahashi
    • Organizer
      15^<th> United European Gastroenterology Week (UEGW2007)
    • Place of Presentation
      Paris, France
    • Related Report
      2009 Final Research Report
  • [Presentation] RA線維芽滑膜細胞におけるRANKLと osteoprotegerin 発現の検討2007

    • Author(s)
      平野史倫
    • Organizer
      第51回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] Increased expression of synovial RANKL is associated with joint destruction in rheumatoid arthritis.2007

    • Author(s)
      Fuminori Hirano
    • Organizer
      The 51st Annual Scientific Meeting of the Japan College of Rheumatology
    • Place of Presentation
      Yokohama, JAPAN
    • Related Report
      2007 Annual Research Report
  • [Presentation] Regulation of RANKL expression by glucocorticoid. in human osteoblast-like cells.2007

    • Author(s)
      Fuminori Hirano
    • Organizer
      The 29th Annual Meeting of the American Society for Bone and Mineral Researxh
    • Place of Presentation
      Honolulu, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] The homeodomain transcription factor CDX2 inhibits human pancreatic cancer cell proliferation by repressing cyclin D1 transcription.2007

    • Author(s)
      Fuminori Hirano
    • Organizer
      15th United European Gastroenterology Week "UEGW 2007"
    • Place of Presentation
      Paris, France
    • Related Report
      2007 Annual Research Report
  • [Book] "呼吸器合併症のスクリーニング検査について" ファーマナビゲーターシリーズ「リウマチ~生物学的製剤編~」(竹内勤編集)2010

    • Author(s)
      平野史倫
    • Publisher
      メディカルレビュー社(印刷中)
    • Related Report
      2009 Final Research Report
  • [Book] "臨床症状-腺外症状-甲状腺病変" シェーグレン症候群の診断と治療マニュアル(住田孝之、江口勝美編集)2009

    • Author(s)
      平野史倫
    • Publisher
      診断と治療社
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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