Molecular analysis of the mechanisms for articular cartilage degeneration induced by metabolic syndrome

• Project/Area Number: 19591754
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KOTO Tsuyoshi Tokyo Medical and Dental University, 医学部附属病院, 助教 (80447490)
• Co-Investigator(Kenkyū-buntansha): ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄附講座講師 (50345279) ; 下地 尚 (財)癌研究会, ゲノムセンター遺伝子発現解析部門, 研究員 (40370150) ; 竹田 秀 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30376727) ; 四宮 謙一 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20111594)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ob / obマウス / 高脂肪食 / 網羅的解析 / 変形性関節症 / 脂質代謝 / 糖代謝

Research Abstract

Leptin deficiency apparently affected articular chondrocyte metabolism independent of the effect of mechanical stress alteration or sympathetic nerve regulation.

Research Products

• [Presentation] Leptin regulation of articular chondrocyte is independent of mechanical stress or sympathetic nerve stimuraltion (2009)
  • Author(s): T. Kato, H. OCHI, S. Takeda, K. Tsuji, D. Koga, Y. Hara, M. Tagawa, K. Shinomiya, Y. Asou
  • Organizer: 米国骨代謝学会
• [Presentation] Leptin regulation of articular chondrocyte is independent of mechanical stress or sympathetic nerve stimuraltion. (2009)
  • Author(s): 加藤剛、麻生義則, ほか
  • Organizer: 米国骨代謝学会
  • Place of Presentation: 米国・デソバー
• [Remarks] ホームページ等