Molecular analysis of the mechanisms for articular cartilage degeneration induced by metabolic syndrome
| Project/Area Number |
19591754
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KOTO Tsuyoshi Tokyo Medical and Dental University, 医学部附属病院, 助教 (80447490)
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| Co-Investigator(Kenkyū-buntansha) |
ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄附講座講師 (50345279)
下地 尚 (財)癌研究会, ゲノムセンター遺伝子発現解析部門, 研究員 (40370150)
竹田 秀 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30376727)
四宮 謙一 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (20111594)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ob / obマウス / 高脂肪食 / 網羅的解析 / 変形性関節症 / 脂質代謝 / 糖代謝 |
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| Research Abstract |
Leptin deficiency apparently affected articular chondrocyte metabolism independent of the effect of mechanical stress alteration or sympathetic nerve regulation.
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Report
(4 results)
Research Products
(3 results)
