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Cerebral protective effects of cromakalim, dexmedetomidine, and Rho-kinase antagonist during ischemia reperfusion period

Research Project

Project/Area Number 19591784
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Yamanashi

Principal Investigator

KIUCHI Riko  University of Yamanashi, 大学院・医学工学総合研究部, 助教 (90377565)

Co-Investigator(Kenkyū-buntansha) ISHIYAMA Tadahiko  山梨大学, 医学部・附属病院, 准教授 (90293448)
SHIBUYA Kazuhiro  山梨大学, 大学院・医学工学総合研究部, 助教 (30402027)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脳虚血 / クロマカリム / デクスメデトミジン / ローキナーゼ阻害薬 / クラニアルウインドウ
Research Abstract

ウサギの脳虚血・再灌流モデルで、Rhoキナーゼ阻害薬の効果を検討した。Rhoキナーゼ阻害薬は、脳軟膜動脈を拡張させた。Rhoキナーゼ阻害薬の虚血前投与により、再灌流後の脳血管収縮が抑制された。 Rhoキナーゼ阻害薬の局所投与では、脳虚血再灌流時に、血圧、心拍数は安定せず、代謝性アシドーシス、血漿ブドウ糖の上昇が認められた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2009 2008 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (8 results)

  • [Journal Article] The direct effects of propofol on pial microvessels in rabbits2009

    • Author(s)
      Shibuya K, Ishiyama T, Ichikawa M, Sato H, Okuyama K, Sessler DI, Matsukawa T.
    • Journal Title

      J Neurosurg Anesthesiol 21

      Pages: 40-46

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravenous famotidine does not always change core temperature during general anesthesia2009

    • Author(s)
      Sato H, Yamakage M, Okuyama K, Imai Y, Iwashita H, Masamune T, IshiyamaT, Matsukawa T.
    • Journal Title

      J Anesth 23

      Pages: 151-153

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary bladder temperatures and oesophageal temperatures correlate better in patients with high rather than low urinary flow rates during non-cardiac surgery2008

    • Author(s)
      Sato H, Yamakage M, Okuyama K, Imai Y, Iwashita H, Ishiyama T, Matsukawa T.
    • Journal Title

      Eur J Aaesthesiol 25

      Pages: 805-809

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isovolemic haemodilution decreases the shivering threshold in rabbits2008

    • Author(s)
      Imai Y, Yamakage M, Sato H, Okuyama K, Ishiyama T, Matsukawa T.
    • Journal Title

      Eur J Anaesthesiol 25

      Pages: 450-453

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] セボフルラン麻酔からJM-1232(-)持続静注による麻酔に切り替えた際の脳血管径の変化2008

    • Author(s)
      石山忠彦, 渋谷和宏, 市川学, 木内理子, 松川隆
    • Journal Title

      神経麻酔・集中治療 2008

      Pages: 71-73

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 麻酔・手術中の覚醒への対応2008

    • Author(s)
      石山忠彦
    • Journal Title

      臨床研修プラクティス 5

      Pages: 95-97

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 合併症を認めたらどうする?2008

    • Author(s)
      石山忠彦
    • Journal Title

      臨床研修プラクティス 5

      Pages: 98-101

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] セボフルラン麻酔からJM-1232(-)持続静注による麻酔に切り替えた際の脳血管径の変化2008

    • Author(s)
      石山忠彦, 渋谷和広, 市川学木内理子, 松川隆
    • Journal Title

      神経麻酔・集中治療2008

      Pages: 71-73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of patient controlled epidural fentanyl in elderly patients2007

    • Author(s)
      Ishiyama T, Iijima T, Sugawara T, Shibuya K, Sato H, Terada Y, Ichikawa M, Sessler DI, Matsukawa T
    • Journal Title

      Anaesthesia 62

      Pages: 1246-1250

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A comparison of three different concentrations of ropivacaine with fentanyl for patient-controlled epidural analgesia2007

    • Author(s)
      Iijima T, Ishiyama T, Kashimoto S, Yamaguchi T, Andoh T, Hanawa K, Tanzawa I, Kawata K, Hanawa T, Hiejima Y
    • Journal Title

      Anesth Analg 105

      Pages: 507-511

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤関連インシデントとその対策および効果についての検討2007

    • Author(s)
      木内理子, 石山忠彦, 小口健史, 樫本温, 松川隆
    • Journal Title

      日本臨床麻酔学会誌 27

      Pages: 728-731

    • NAID

      10019796002

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] プロポフォール麻酔下での脳虚血・再還流後の脳血管径の変化2007

    • Author(s)
      石山忠彦, 渋谷和広, 市川学, 趙航, 松川隆
    • Journal Title

      神経麻酔・集中治療 2007

      Pages: 31-33

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ロポフォール麻酔下での脳虚血・再還流後の脳血管径の変化2007

    • Author(s)
      石山忠彦、渋谷和広、市川学、他
    • Journal Title

      神経麻酔・集中治療2007

      Pages: 31-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳血管に対するJM-1232の直接的効果の検討-Cranial Window法を用いて2008

    • Author(s)
      市川学, 石山忠彦, 渋谷和広, 松川隆
    • Organizer
      日本麻酔科学会第55回学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-12
    • Related Report
      2008 Final Research Report
  • [Presentation] プロポフォール麻酔下での脳虚血・再灌流後の脳血管径の変化2008

    • Author(s)
      石山忠彦, 渋谷和広, 市川学, 趙航, 松川隆
    • Organizer
      第12回日本神経麻酔集中治療研究会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-12
    • Related Report
      2008 Final Research Report
  • [Presentation] The Effects of Topical and Intravenous JM1232(-) on Pial Microcirculation in Rabbits2008

    • Author(s)
      Shibuya K, Ishiyama T, Ichikawa M, Oguchi T, Matsukawa T
    • Organizer
      American Society of Anesthesiologists 2008 Annual Meeting
    • Place of Presentation
      Orlando, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] セボフルランまたはプロポフォールで麻酔されたウサギでの, 全脳虚血・再灌流時の脳動脈径の変化2007

    • Author(s)
      渋谷和広, 石山忠彦, 市川学, 趙航, 松川隆
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] セボフルランまたはプロポフォールで麻酔されたウサギでの、全脳虚血・再灌流時の脳動脈径の変化2007

    • Author(s)
      渋谷和広、石山忠彦、市川学、趙航、松川隆
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2007-06-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロポフォール麻酔下での脳虚血・再灌流後の脳血管径の変化2007

    • Author(s)
      石山忠彦, 渋谷和広, 市川学, 趙航, 松川隆
    • Organizer
      第11回日本神経麻酔集中治療研究会
    • Place of Presentation
      秋田
    • Year and Date
      2007-04-21
    • Related Report
      2008 Final Research Report
  • [Presentation] プロポフォール麻酔下での脳虚血・再灌流後の脳血管径の変化2007

    • Author(s)
      石山忠彦、渋谷和広, 市川学, 趙航、松川隆
    • Organizer
      第11回日本神経麻酔集中治療研究会
    • Place of Presentation
      秋田市
    • Year and Date
      2007-04-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pial arterial responses to brain ischemia under sevoflurane or propofol anesthesia in rabbits2007

    • Author(s)
      Ishiyama T, Shibuya K, Ichikawa M, Oguchi T, Matsukawa T
    • Organizer
      American Society of Anesthesiologists 2007 Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2008 Final Research Report 2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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