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The role of serotonin 2C receptor RNA editing in the neuropathic pain model

Research Project

Project/Area Number 19591791
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

TAKASHINA Masaki  Osaka University, 医学部附属病院, 講師 (30221352)

Co-Investigator(Kenkyū-buntansha) HAGIHIRA Satoshi  大阪大学, 医学部附属病院, 講師 (90243229)
NAKAE Aya  大阪大学, 医学部附属病院, 特任准教授 (60379170)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsセロトニン2C受容体 / RNA編集 / 神経因性疼痛モデル / 脊髄障害性モデル / 脊髄障害性疼痛 / 脊髄障害性疼痛モデル / 核小体低分子RNA / RBII-52 / SCI / 選択的スプライシング / 脊髄坐滅モデル / 神経因性疼痛
Research Abstract

We investigated the effects on 5HT2C receptor RNA editing efficiency of contusive SCI. Using cloning followed by sequence analysis on spinal cord samples takes, we compared mRNA editing. Our results might be evidence of functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007

All Journal Article (9 results) (of which Peer Reviewed: 2 results) Presentation (15 results)

  • [Journal Article] The role of snoRNA RBII-52 to the serotonin2C receptor in the rat oro-facial neuropathic pain model2009

    • Author(s)
      Kunihiro Nakai, Aya Nakae, Sosuke Oba, Masahiko Shibata, Takashi Mashimo, Koichi Ueda
    • Journal Title

      Neuroscience

    • Related Report
      2009 Final Research Report
  • [Journal Article] The snoRNA RBII-52 regulates alternative splicing of serotonin 2C receptor in the rat oro-facial neuropathic pain model2009

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Mari Yoshida, Akiko Mikami, Masaki Takashina, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashimo
    • Journal Title

      Neuroscience

    • Related Report
      2009 Final Research Report
  • [Journal Article] The role of snoRNA(RBII-52) in a rat model of oro-facial neuropathic pain2009

    • Author(s)
      A. Nakae, K. Nakai, T. Tanaka, S. Hagihira, T. Mashimo
    • Journal Title

      European Journal of Anesthesiology 26

    • Related Report
      2009 Final Research Report
  • [Journal Article] Role of constitutively active 5HT2C receptors following spinal cord injury in rats2008

    • Author(s)
      K.C. Murray, A. Nakae, T. Ballou, R. Vavrek, K. Fouad, M.M. Rank, M. Stephens, R. Anelli, P.J. Harvey, C. Heckman, D.J. Bennett
    • Journal Title

      Neuroscience

    • Related Report
      2009 Final Research Report
  • [Journal Article] The role of RNA editing of the serotonin 2C receptor in a rat model of oro-facial neuropathic pain2008

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashimo
    • Journal Title

      The European Journal of Neuroscience 27(9)

      Pages: 2373-9

    • Related Report
      2009 Final Research Report
  • [Journal Article] Serotonin 2C receptor mRNA editing in neuropathic pain model2008

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashimo
    • Journal Title

      Neuroscience Research 60(2)

      Pages: 228-231

    • NAID

      10031136224

    • Related Report
      2009 Final Research Report
  • [Journal Article] The role of RNA editing of the serotonin 2C receptor in a rat model of oro-facial neuropathic pain.2008

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Takashi Mashimo, Et al.
    • Journal Title

      European Journal of Nesuroscience 27

      Pages: 2373-2379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of RNA editing of serotonin2C receptor in a rat model of oro-facial neuropathic pain2007

    • Author(s)
      A. Nakae, K. Nakai, T. Tanaka, K. Miyake, S. Hagihira, M. Shibata, K. Ueda, T. Mashimo
    • Journal Title

      Neuroscience

    • Related Report
      2009 Final Research Report
  • [Journal Article] Serotonin2C receptor mRNA editing in neuropathic pain model2007

    • Author(s)
      Aya Nakae, Takashina Masaki
    • Journal Title

      Neuroscience Research 60-2

      Pages: 228-231

    • NAID

      10031136224

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経因性疼痛モデルでの核小体RNA(RBII-52)の関与2009

    • Author(s)
      吉田真理, 中江文, ほか
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] The snoRNA RBII-52 regulates alternative splicing of serotonin 2C receptor in the rat oro-facial neuropathic pain model2009

    • Author(s)
      Aya Nakae, Masaki Takashina, 他
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 核小体RNA、RBII-52の神経因性疼痛でのセロトニン2C受容体に対する役割2009

    • Author(s)
      吉田真理、田中達哉、石田葉子、中江文、中井國博、三上晶子、大場創介、柴田政彦、眞下節、上田晃一
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 核小体RNAのRBII-52によるラット顔面神経因性疼痛モデルにおけるセロトニン2Cレセプターのスプライスバリアントの制御2009

    • Author(s)
      三上晶子、田中達哉、石田葉子、中江文、中井國博、吉田真理、柴田政彦、上田晃一、眞下節
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of snoRNA RBII-52 to the serotonin2C receptor in the rat oro-facial neuropathic pain model2009

    • Author(s)
      Kunihiro Nakai, Aya Nakae, Sosuke Oba, Masahiko Shibata, Takashi Mashimo, Koichi Ueda
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, Ilinoi
    • Related Report
      2009 Final Research Report
  • [Presentation] The snoRNA RBII-52 regulates alternative splicing of serotonin 2C receptor in the rat oro-facial neuropathic pain model2009

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Mari Yoshida, Akiko Mikami, Masaki Takashina, Satoshi Hagihira, Masahiko Shibata, Koichi Ueda, Takashi Mashimo
    • Organizer
      Neuroscience 2009
    • Place of Presentation
      Chicago, Ilinoi
    • Related Report
      2009 Final Research Report
  • [Presentation] 眼窩下神経絞扼モデルにおける核小体RNA(RBII-52)の関わり2009

    • Author(s)
      中江文、中井國博、柴田政彦、上田幸一、眞下節
    • Organizer
      第31回日本疼痛学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of snoRNA in a rat model of oro-facial neuropathic pain2009

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Satoshi Hagihira, Takashi Mashimo
    • Organizer
      Euroanaesthesia 2009
    • Place of Presentation
      Milano, Italy
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of GABAergic tonic inhibition in rat oro-facial neuropathic pain model2009

    • Author(s)
      Kunihiro Nakai, Aya Nakae, Sosuke Oba, Takashi Mashimo, Koichi Ueda
    • Organizer
      5th World Congress World Institute of Pain
    • Place of Presentation
      New York, NY
    • Related Report
      2009 Final Research Report
  • [Presentation] Correlation between peripheral P2X4 receptor expression and nerve injury in rat oro-facial neuropathic pain model2009

    • Author(s)
      Aya Nakae, Kunihiro Nakai, Tatsuya Tanaka, Koichi Ueda, Takashi Mashimo
    • Organizer
      5th World Congress World Institute of Pain
    • Place of Presentation
      New York, NY
    • Related Report
      2009 Final Research Report
  • [Presentation] 脊髄におけるセロトニン2C受容体のRNA編集とその病態へのかかわり2009

    • Author(s)
      中江文、柴田政彦、高階雅紀、萩平哲、眞下節
    • Organizer
      平成20年度生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
    • Place of Presentation
      岡崎
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of constitutively active 5HT2C receptors following spinal cord injury in rats2008

    • Author(s)
      K.C. Murray, A. Nakae, T. Ballou, R. Vavrek, K. Fouad, M.M. Rank, M. Stephens, R. Anelli, P.J. Harvey, C. Heckman, D.J. Bennett
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Washington, DC
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経因性疼痛におけるセロトニン2C受容体の関与2007

    • Author(s)
      中江 文、高階 雅紀、萩平 哲
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌コンヴェンションセンター
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of RNA editing of serotonin2C receptor in a rat model of oro-facial neuropathic pain2007

    • Author(s)
      A. Nakae, K. Nakai, T. Tanaka, K. Miyake, S. Hagihira, M. Shibata, K. Ueda, T. Mashimo
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego, CA
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経因性疼痛におけるセロトニン2C受容体の関与2007

    • Author(s)
      中江文、田中達哉、高階雅紀、上山博史、萩平哲、眞下節
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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