Study for experimental pathophysiology of non-occlusive mesenteric ischemia(NOMI) and effect of clinical pharmacological therapy to NOMI.

• Project/Area Number: 19591806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nagasaki University
• Principal Investigator: MAKITA Tetsuji Nagasaki University, 大学院・医歯薬学総合研究科, 准教授 (00229337)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Toshiaki 長崎大学, 病院, 助教 (00325656)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: NOMI / 臨床

Research Abstract

We made the porcine model of non-occlusive mesenteric ischemia (NOMI). We compared the effects of carperitide on the mesenteric blood flow and CO2 tension of intestinal mucosa with that of papaverine. There was niether improvement of mesenteric blood flow nor CO2 tension with both drugs. We considered that the porcine model of NOMI was not suitable for this study.

Research Products

• [Journal Article] Synthetic atrial natriuretic peptide improves systemic and splanchnic circulation and has a lung-protective effect during endotoxemia in pigs (2010)
  • Author(s): Sekino M, Makita T, Ureshino H, Cho S, Sumikawa K
  • Journal Title: Anesth Analg 110 Pages: 141-7
  • Peer Reviewed
• [Journal Article] Synthetic atrial natriuretic peptide improves systemic and splanchnic circulation and has a lung-protective effect during endotoxemia in pigs. (2010)
  • Author(s): Sekino M, Makita T, Ureshino H, Cho S, Sumikawa K
  • Journal Title: Anesth Analg 110, Pages: 141-7
  • Peer Reviewed
• [Journal Article] Effects of amitriptyline, a tricyclic antidepressant, on smooth muscle reactivity in isolated rat trachea (2009)
  • Author(s): Matsunaga S, Shibata O, Nishioka K, Tsuda A, Makita T, Sumikawa K
  • Journal Title: J Anesth 23 Pages: 385-391
  • NAID: 10027264183
  • Peer Reviewed
• [Journal Article] 麻酔科学レクチャー (2009)
  • Author(s): 槇田徹次
  • Journal Title: PCPS 1 Pages: 1025-1028
• [Journal Article] 印象記「第56回日本麻酔科学会学術集会」 (2009)
  • Author(s): 槇田徹次
  • Journal Title: ペインクリニック 30 Pages: 1610-1611
• [Journal Article] High concentrations of landiolol, a b1-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway (2008)
  • Author(s): Shibata O, Nishioka K, Yamaguchi M, Makita T, Sumikawa K
  • Journal Title: J Anesth 22 Pages: 21-26
  • Peer Reviewed
• [Journal Article] 動脈穿刺/動脈圧測定の必要性と可能性を考慮して再挿入を (2008)
  • Author(s): 槇田徹次
  • Journal Title: LiSA 15 Pages: 476-477
• [Journal Article] 自宅で心肺停止に陥ったが心肺蘇生後の脳低温療法が奏功し後遺症なく救命しえた1症例 (2008)
  • Author(s): 松本聡治朗、中村利秋、槇田徹次、澄川耕二
  • Journal Title: 長崎医学会雑誌 83 Pages: 136-141
  • Peer Reviewed
• [Journal Article] Effect of propofol and ketamine on ATP-induced contraction of the rat trachea (2007)
  • Author(s): Yamaguchi M, Shibata O, Saito M, Yoshimura M, Nishioka K, Makita T, Sumikawa K
  • Journal Title: J Anesth 21 Pages: 37-41
  • NAID: 10018730181
  • Peer Reviewed
• [Journal Article] Succinylcholine potentiates acetylcholine-induced contractile and phosphatidylinositol responses of rat trachea (2007)
  • Author(s): Nishioka K, Shibata O, Yamaguchi M, Yoshimura M, Makita T, Sumikawa K
  • Journal Title: J Anesth 21 Pages: 171-175
  • NAID: 10020093550
  • Peer Reviewed
• [Journal Article] The effects of fentanyl on the contractile response of the ovalbumin-sensitized rat trachea (2007)
  • Author(s): Nishioka K, Shibata O, Yamaguchi M, Makita T, Sumikawa K
  • Journal Title: Anesth Analg 104 Pages: 1103-1108
  • Peer Reviewed
• [Journal Article] Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves phosphatidylinositol-3-OH kinase-Akt and a mitochondrial permeability transition pore during early reperfusion (2007)
  • Author(s): Tosaka S, Makita T, Tosaka R, Maekawa T, Cho S, Hara T, Ureshino H, Sumikawa K
  • Journal Title: J Anesth 21 Pages: 176-180
  • NAID: 10020093566
  • Peer Reviewed
• [Journal Article] 中心静脈カテーテル挿入4日後に椎骨動脈への誤挿入が判明した1症例 (2007)
  • Author(s): 吉富修、趙成三、前川拓治、原哲也、槇田徹次、澄川耕二
  • Journal Title: 日本臨床麻酔学会雑誌 27 Pages: 723-727
  • NAID: 10019795996
  • Peer Reviewed
• [Journal Article] 急性腎不全、急性呼吸不全を呈した化膿性椎間板炎の1例 (2007)
  • Author(s): 中村利秋、鳥居和広、前川拓治、馬場秀夫、槇田徹次、澄川耕二
  • Journal Title: 長崎医学会雑誌 82 Pages: 135-142
  • NAID: 110006447289
  • Peer Reviewed
• [Journal Article] 急性腎不全、最近3年間の血液疾患患者の集中治療部への収容状況に関する検討 (2007)
  • Author(s): 中村利秋、福島卓也、槇田徹次、澄川耕二
  • Journal Title: 長崎医学会雑誌 82 Pages: 163-168
  • Peer Reviewed
• [Journal Article] Levy JH Comparison of relaxation responses to multiple vasodilators in TxA2-analog and endothelin-1-precontracted pulmonary arteries (2007)
  • Author(s): Piamsomboon C, Tanaka K, Szlam F, Makita T, Huraux C
  • Journal Title: Acta Anaesthesiol Scand 51 Pages: 714-721
  • Peer Reviewed
• [Presentation] Atrial natriuretic peptide improves pulmonary circulation and function during endotoxemia in pigs (2009)
  • Author(s): M akita T, Sekino M, Sumikawa K
  • Organizer: Eur J Anaesthesiol
  • Place of Presentation: The European Anaesthesiology Congress 2009 Milan, Italy
• [Presentation] Atrial natriuretic peptide improves pulmonary circulation and function during endotoxemia in pigs. (2009)
  • Author(s): Makita T
  • Organizer: The European Anaesthesiology Congress
  • Place of Presentation: Milan