The anesthetic modulation of the protective effect of statin on the endothelium function in diabetic and hypertensive animal models.
Project/Area Number |
19591815
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Wakayama Medical University |
Principal Investigator |
OGAWA Koji Wakayama Medical University, 医学部, 准教授 (30204077)
|
Co-Investigator(Kenkyū-buntansha) |
MIZUMOTO Kazuhiro 和歌山県立医科大学, 医学部, 准教授 (50239258)
HATANO Yoshio 和歌山県立医科大学, 医学部, 教授 (70115913)
|
Project Period (FY) |
2007 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | スタチン / 血管内皮細胞 / 一酸化窒素 / 揮発性麻酔薬 / 糖尿病 / セボフルラン / 弛緩反応 |
Research Abstract |
Exposure of cultured endothelial cells to simvastatin induced NO production. The increase in NO production was significantly inhibited in the presence of sevoflurane. Sevoflurane also inhibited increase in eNOS expression in response to simvastatin, but not eNOSmRNA expression. It is suggested the transcriptional modification of eNOS may be involved in the statin-induced activation of eNOSNO signaling pathways. Sevoflurane appears to affect this process.
|
Report
(6 results)
Research Products
(32 results)