Fundamental research for clinical use of insulin-like growth factorin prostate cancer
Project/Area Number |
19591833
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Akita University |
Principal Investigator |
TSUCHIYA Norihiko Akita University, 医学部, 准教授 (70282176)
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Co-Investigator(Kenkyū-buntansha) |
YUASA Takeshi 秋田大学, 医学部, 講師 (00314162)
KUMAZAWA Teruaki 秋田大学, 医学部, 助教 (60400488)
INOUE Takamitsu 秋田大学, 医学部, 助教 (60375243)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 前立腺癌 / IGF-I / 遺伝子多型 / IGF-I受容体 / 遺伝子多 / 免疫染色 |
Research Abstract |
IGF-I遺伝子多型の中でもpromoter領域に存在するCA反復多型、intron 2に存在するrs12423791、ハプロタイプブロック3に存在するrs7136446 とrs6220 は、進行性前立腺癌の癌特異的生存期間と全生存期間との間に有意な関連が認められ、これらが進行性前立腺癌の予後予測マーカーとして臨床応用される可能性が示された。
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Polymorphisms of fibroblastgrowth factor receptor 4 have associationwith the development of prostate cancer andbenign prostatic hyperplasia and theprogression of prostate cancer in a Japanesepopulation2008
Author(s)
Ma Z, Tsuchiya N, Yuasa T, Inoue T,Kumazawa T, Narita S, Horikawa Y, TsurutaH, Obara T, Saito M, Satoh S, Ogawa O and Habuchi T
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Journal Title
Int J Cancer 123
Pages: 2574-2579
Related Report
Peer Reviewed
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[Journal Article] Prognostic significance ofHIF-1 alpha polymorphisms in transitionalcell carcinoma of the bladder2008
Author(s)
Nadaoka J, Horikawa Y, Saito M,Kumazawa T, Inoue T, Narita S, Yuasa T,Satoh S, Nishiyama H, Ogawa O, TsuchiyaN and Habuchi T
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Journal Title
Int J Cancer 122
Pages: 1297-1302
Related Report
Peer Reviewed
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[Journal Article] A genetic polymorphism of theosteoprotegerin gene is associated with anincreased risk of advanced prostate cancer2008
Author(s)
Narita N, Yuasa T, Tsuchiya N,Kumazawa T, Narita S, Inoue T, Ma Z, SaitoM, Horikawa Y, Satoh S, Ogawa O and Habuchi T
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Journal Title
BMC Cancer 8
Pages: 224-232
Related Report
Peer Reviewed
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[Journal Article] Clinical implication of vascularendothelial growth factor T-460Cpolymorphism in the risk and progression ofprostate cancer2007
Author(s)
Fukuda H, Tsuchiya N, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O and Habuchi T
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Journal Title
Oncol Rep 18
Pages: 1155-1163
Related Report
Peer Reviewed
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[Presentation] Clinial implication of vascularendothelial growth factor (VEGF) T-460C2007
Author(s)
Tsuchiya N, Fukuda H, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O. and Habuchi, T
Organizer
polymorphism in the risk and progression ofprostate cancer
Place of Presentation
AUA annual meeting, Atlanta
Related Report
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[Presentation] 進行性前立腺癌の予後におけるhGH、IGF-I ならびにIL-6 遺伝子多型の関与2007
Author(s)
土谷順彦, 成田伸太郎, 熊澤光明, 井上高光, 馬智勇, 齋藤満, 堀川洋平, 湯浅健, 松浦忍, 佐藤滋, 小川修, 羽渕友則
Organizer
2007日本泌尿器科学会総会
Place of Presentation
神戸
Related Report
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