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Fundamental research for clinical use of insulin-like growth factorin prostate cancer

Research Project

Project/Area Number 19591833
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionAkita University

Principal Investigator

TSUCHIYA Norihiko  Akita University, 医学部, 准教授 (70282176)

Co-Investigator(Kenkyū-buntansha) YUASA Takeshi  秋田大学, 医学部, 講師 (00314162)
KUMAZAWA Teruaki  秋田大学, 医学部, 助教 (60400488)
INOUE Takamitsu  秋田大学, 医学部, 助教 (60375243)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords前立腺癌 / IGF-I / 遺伝子多型 / IGF-I受容体 / 遺伝子多 / 免疫染色
Research Abstract

IGF-I遺伝子多型の中でもpromoter領域に存在するCA反復多型、intron 2に存在するrs12423791、ハプロタイプブロック3に存在するrs7136446 とrs6220 は、進行性前立腺癌の癌特異的生存期間と全生存期間との間に有意な関連が認められ、これらが進行性前立腺癌の予後予測マーカーとして臨床応用される可能性が示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2008 2007 Other

All Journal Article (16 results) (of which Peer Reviewed: 15 results) Presentation (7 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Polymorphisms of fibroblastgrowth factor receptor 4 have associationwith the development of prostate cancer andbenign prostatic hyperplasia and theprogression of prostate cancer in a Japanesepopulation2008

    • Author(s)
      Ma Z, Tsuchiya N, Yuasa T, Inoue T,Kumazawa T, Narita S, Horikawa Y, TsurutaH, Obara T, Saito M, Satoh S, Ogawa O and Habuchi T
    • Journal Title

      Int J Cancer 123

      Pages: 2574-2579

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance ofHIF-1 alpha polymorphisms in transitionalcell carcinoma of the bladder2008

    • Author(s)
      Nadaoka J, Horikawa Y, Saito M,Kumazawa T, Inoue T, Narita S, Yuasa T,Satoh S, Nishiyama H, Ogawa O, TsuchiyaN and Habuchi T
    • Journal Title

      Int J Cancer 122

      Pages: 1297-1302

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genetic polymorphism of theosteoprotegerin gene is associated with anincreased risk of advanced prostate cancer2008

    • Author(s)
      Narita N, Yuasa T, Tsuchiya N,Kumazawa T, Narita S, Inoue T, Ma Z, SaitoM, Horikawa Y, Satoh S, Ogawa O and Habuchi T
    • Journal Title

      BMC Cancer 8

      Pages: 224-232

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Candidate genes involved inenhanced growth of human prostate cancer2008

    • Author(s)
      Narita S, Tsuchiya N, Saito M, Inoue T,Kumazawa T, Yuasa T, Nakamura A and Habuchi T
    • Journal Title

      under high fat feeding identified bymicroarray analysis. Prostate 68

      Pages: 321-335

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association ofgenetic polymorphisms at 8q24 with the riskof prostate cancer in a Japanese population2008

    • Author(s)
      Terada N, Tsuchiya N, Ma Z, Shimizu Y,Kobayashi T, Nakamura E, Kamoto T,Habuchi T and Ogawa O
    • Journal Title

      Prostate 68

      Pages: 1689-1695

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prost ate cancer in a Japanese population2008

    • Author(s)
      Ma Z
    • Journal Title

      Int J Cancer 123

      Pages: 2574-2579

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of HIF-1 alpha polymorphisms in transitional cell carcinoma of the bladder2008

    • Author(s)
      Nadaoka J
    • Journal Title

      Int J Cancer 122

      Pages: 1297-1302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genetic polymorphism of the osteoprotegerin gene is associated with an increased risk of advanced prostate cancer2008

    • Author(s)
      Narita N
    • Journal Title

      BMC Cancer 8

      Pages: 224-232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Candidate genes involved in enhanced growth of human prostate cancer under high fat feeding identified by microarray analysis2008

    • Author(s)
      Narita S
    • Journal Title

      Prostate 68

      Pages: 321-335

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of genetic polymorphisms at 8q24 with the risk of prostate cancer in a Japanese population2008

    • Author(s)
      Terada N
    • Journal Title

      Prostate 68

      Pages: 1689-1695

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of HIF-1 alpha polymorphisms in transitional cell carcinoma of the bladder.2008

    • Author(s)
      Nadaoka J, Horikawa Y, Saito M, Kumazawa T, et. al.
    • Journal Title

      Int J Caner 15

      Pages: 1297-1302

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implication of vascularendothelial growth factor T-460Cpolymorphism in the risk and progression ofprostate cancer2007

    • Author(s)
      Fukuda H, Tsuchiya N, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O and Habuchi T
    • Journal Title

      Oncol Rep 18

      Pages: 1155-1163

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lowconcentrations of the histone deacetylaseinhibitor, depsipeptide, enhance the effectsof gemcitabine and docetaxel in hormonerefractory prostate cancer cells2007

    • Author(s)
      Kanzaki M, Kakinuma H, Kumazawa T,Inoue T, Saito M, Narita S, Yuasa T,Tsuchiya N and Habuchi T
    • Journal Title

      Oncol Rep 17

      Pages: 761-767

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 立腺癌の遺伝子多型研究. 前立腺癌-基礎・臨床研究のアップデート-2007

    • Author(s)
      土谷順彦
    • Journal Title

      日本臨牀 65

      Pages: 60-64

    • Related Report
      2008 Final Research Report
  • [Journal Article] Clinical implication of vascular endothehal growth factor T-460C polymorphism in the risk and progression of prostate cancer.2007

    • Author(s)
      Fukuda H, Tsuchiya N, Nahta S, et. al.
    • Journal Title

      Oncol Rep. 18

      Pages: 1155-1163

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low concentrations of the histone deacetylase inhibitor, depsipeptide, enhance the effects of gemcitabine and docetaxel in hormone refractory prostate cancer cells.2007

    • Author(s)
      Kanzaki M, Kakinuma H, Kumazawa T, et. al.
    • Journal Title

      Oncol Rep. 17

      Pages: 761-767

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ホルモン不応性前立腺癌細胞株に対するGLI2アンチセンスオリゴの抗腫瘍効果2008

    • Author(s)
      成田伸太郎
    • Organizer
      日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] miRNA181aはポリコーム群遺伝子Mel-18の発現を修飾し前立腺癌の進展に関与する2008

    • Author(s)
      湯浅健
    • Organizer
      日本癌治療学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] Geneexpression in response to high-fat feeding inhuman prostate cancer xenograft model2007

    • Author(s)
      Narita S, Tsuchiya N, Saito M, Inoue T,Kumazawa T, Horikawa Y, Yuasa T Matsuura S, Satoh S and Habuchi T
    • Organizer
      AUA annual meeting
    • Place of Presentation
      Atlanta
    • Related Report
      2008 Final Research Report
  • [Presentation] Clinial implication of vascularendothelial growth factor (VEGF) T-460C2007

    • Author(s)
      Tsuchiya N, Fukuda H, Narita S,Kumazawa T, Horikawa Y, Inoue T, Saito M,Yuasa T, Matsuura S, Satoh S, Ogawa O. and Habuchi, T
    • Organizer
      polymorphism in the risk and progression ofprostate cancer
    • Place of Presentation
      AUA annual meeting, Atlanta
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行性前立腺癌の予後におけるhGH、IGF-I ならびにIL-6 遺伝子多型の関与2007

    • Author(s)
      土谷順彦, 成田伸太郎, 熊澤光明, 井上高光, 馬智勇, 齋藤満, 堀川洋平, 湯浅健, 松浦忍, 佐藤滋, 小川修, 羽渕友則
    • Organizer
      2007日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] A geneticpolymorphism of the Osteoprotegerin geneis associated with an increasing risk ofadvanced prostate cancer2007

    • Author(s)
      Narita N, Yuasa T, Tsuchiya N,Kumazawa T, Narita S, Saito M, Horikawa Y,Inoue T, Satoh S and Habuchi T
    • Organizer
      2007日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 進行性前立腺癌の予後におけるhGH、 IGF-IbならびにIL-6遺伝子多型の関与.2007

    • Author(s)
      土谷順彦, 成田伸太郎, 熊澤光明, 他
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2007 Annual Research Report
  • [Book] 前立腺癌リスクと遺伝子多型.泌尿器疾患治療の新しいストラテジー2007

    • Author(s)
      土谷順彦
    • Publisher
      メジカルビュー社
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/researcher/researchresults.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~hinyoki/researcher/rs2007.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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