Mechanism of renal cell carcinoma carcinogenesis arising in the acquired cystic kidney disease
Project/Area Number |
19591870
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Keio University |
Principal Investigator |
MOTOTSUGU Oya Keio University, 医学部, 教授 (00213885)
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Co-Investigator(Kenkyū-buntansha) |
MIKAMI Shuji 慶應義塾大学, 医学部, 助教 (20338180)
金井 邦光 慶應義塾大学, 医学部, 助教 (80365361)
|
Research Collaborator |
MIYAJIMA Akira 慶應義塾大学, 医学部, 医学部 (90245572)
ISHIDA Masaru 慶應義塾大学, 医学部, 研究員 (80383876)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 腎細胞癌 / 腎不全 / 発がん / 透析 / 嚢胞 / 尿細管 / aryl hydrocarbon receptor / 尿路上皮腫瘍 |
Research Abstract |
透析患者では一般人よりも腎細胞癌の発生率が10~40倍高い。透析腎は多数の大小不同の嚢胞を合併し、acquired cystic kidney disease(ACKD)と呼ばれている。嚢胞をCarbonic anhydrase IX(CA9)と尿細管の部位特異的に発現するAquaporin(AQP)1と2の免疫染色を行った。透析腎から発生する腎細胞癌には嚢胞の多層化より発がんに移行する場合とCA9陽性細胞から発生する場合との2つの発がん過程が存在することが示唆された。
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Lymphovascular invasion is a powerful predictor of clinical outcomes in patients with node-negative uppertract urothelial carcinoma2009
Author(s)
Kikuchi E, Shariat SF, Margulis V, Karakiewicz P, Mikami S, Lotan Y, Remzi M, Bolenz C, Zigeuner R, Weizer R, Montorsi F, Bensalah K, Koppie TM, Fernandez MI, Wood CG, Roscigno M, Raman JD, Suardi N, Strobel P, Oya M
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Journal Title
J Clin Oncol 27(4)
Pages: 612-618
Related Report
Peer Reviewed
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[Journal Article] Lymphovascular invasion is a powerful predictor of clinical outcomes in patients with node-negative uppertract urothelial carcinoma.2009
Author(s)
Kikuchi E, Shariat SF, Margulis V, Karakiewicz P, Mikami S, Lotan Y, Remzi M, Bolenz C, Zigeuner R, Weizer R, Montorsi F, Bensalah K, Koppie TM, Fernandez MI, Wood CG, Roscigno M, Raman JD, Suardi N, Strobel p, Qya M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Papillary renal cell carcinoma : clinicopathological characteristics in 40 patients2008
Author(s)
Kosaka, T., Mikami, S., Miyajima, A., Kikuchi, E., Nakagawa, K., Ohigashi, T., Nakashima, J., Oya, M
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Journal Title
Clin Exp Nephrol 12
Pages: 195-199
NAID
Related Report
Peer Reviewed
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[Journal Article] The novel NF-kB activation inhibitor dehydroxymethy-epoxyquinomicin suppresses anti-thy1.1-induced glomerulonephritis in rats2008
Author(s)
Kosaka, T., Miyajima, A., Kikuchi, E., Horiguchi, Y., Umezawa, K., Ohigasi, T., Nakashima, J., Asano, T., Oya, M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Decreased acetylation of histone H3 in renal cell carcinoma : a potential target of histone deacetylase inhibitors2008
Author(s)
Kanao, K., Mikami, S., Mizuno, R., Shinojima, T., Murai, M., Oya, M
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Journal Title
J. Urol 180
Pages: 1131-1136
Related Report
Peer Reviewed
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[Journal Article] Expression of heparanase in renal cell carcinomas : implications for tumor invasion and prognosis2008
Author(s)
Mikami, S., Oya, M., Shimoda, M., Mizuno, R., Ishida, M., Kosaka, T., Mukai, M., Nakajima, M., Okada, Y
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Journal Title
Clin Cancer Res 14
Pages: 6055-6061
Related Report
Peer Reviewed
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[Journal Article] apillary renal cell carcinoma : clinicopathological characteristics in 40 patients.2008
Author(s)
Kosaka, T., Mikami, S., Miyajima, A., Kikuchi, E., Nakagawa, K., Ohigashi, T. . Nakashima, J., Ova. M.
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Journal Title
Clin Exp Nephrol 12
Pages: 195-199
Related Report
Peer Reviewed
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[Journal Article] The novel NF-kB activation inhibitor dehydroxymethy-epoxyquino micin suppresses anti-thy1.1-induced glomerulonephritis in rats.2008
Author(s)
Kosaka, T., Miyajima, A., Kikuchi, E., Horiguchi, Y., Umezawa, K., Ohigasi, T., Nakashima, J., Asano, T, Oya. M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Decreased acetylation of histone H3 in renal cell carcinoma : a potential target of histone deacetylase inhibitors.2008
Author(s)
Kanao, K., Mikami, S, Mizuno, R., Shinoiima, T., Murai, M., Ova. M.
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Journal Title
J. Urol 180
Pages: 1131-1136
Related Report
Peer Reviewed
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[Journal Article] Expression of heparanase in renal cell carcinomas : implications for tumor invasion and prognosis.2008
Author(s)
Mikami, S., Oya, M., Shimoda, M., Mizuno, R., Ishida, M., Kosaka, T., Mukai, M., Nakajima, M., Okada, Y.
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Journal Title
Clin Cancer Res 14
Pages: 6055-6061
Related Report
Peer Reviewed
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[Presentation] Elevated expression of aryl hydrocarbon receptor in renal cell carcinoma : its associated with cigarette smoke and the prognosis2009
Author(s)
M. Ishida., S. Mikami., T. Kosaka., H. Kono., E. Kikuchi., H. Nagata., A. Miyajima., K. Nakagawa., M. Mukai., Y. Okada., M. Oya
Organizer
American Urological Association, 104th Annual Meeting
Place of Presentation
McCormick Place West Building Chicago, Illinois, USA
Year and Date
2009-04-26
Related Report
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[Presentation] Prognostic significance of nuclear expression of aryl hydrocarbon receptor in urothelial carcinoma of the upper urinary tract2009
Author(s)
M. Ishida, S. Mikami, E. Kikuchi, T. Kosaka, H. Kono, H. Nagata, A. Miyajima, K. Nakagawa, M. Murai, Y. Okada, M. Oya
Organizer
24^<th> Annual European Association of Urology congress
Place of Presentation
Stockholmsmassan-Stockholm International Fairs. Sweden
Year and Date
2009-03-19
Related Report
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