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Basic and clinical research on pan-HLA peptide vaccination for prostate cancer

Research Project

Project/Area Number 19591877
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKurume University

Principal Investigator

NOGUCHI Masanori  Kurume University, 医学部, 准教授 (10140691)

Co-Investigator(Kenkyū-buntansha) 山田 亮  久留米大学, 先端癌治療研究センター, 教授 (50158177)
内藤 雅康  久留米大学, 医学部, 研究員 (00446080)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords癌 / 免疫学 / バイオテクノロジー / ペプチドワクチン / 再燃前立腺癌 / テーラーメイド / 汎HLA / ペプチドワクチン療法 / HLA-A3ファミリー
Research Abstract

HLA-A3、-A11、 -A31、 -A33分子全てに共通して結合能を有するペプチドとしてSART3-109を選択した。さらにSART3-109の免疫原性を、ペプチド特異的でHLA拘束性 のCTL誘導能測定により解析し、HLA-A3スーパータイプに結合能があることを確認した。これまでに同定したHLA-A3スーパータイプペプチド5種類と、現在臨床試験にて使用中のHLA-A2拘束性ペプチド12種類、及びHLA-A24拘束性ペプチド14種類を用いて、再燃前立腺癌患者に対するテーラーメイドペプチドワクチン((汎HLA対応型テーラーメイドペプチドワクチン)を実施し、その安全性、有用性を検討する第1相臨床試験を行い、安全性ならびに免疫応答を認め、PSA低下症例も認めた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (34 results)

All 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 10 results) Presentation (20 results)

  • [Journal Article] Capability of SART3109-118 peptide to induce cytotoxic T-lymphocytes from prostate cancer patients with HLA class .-A11, -A31, and -A33 alleles.2009

    • Author(s)
      Mohamed ER, Naito M, Terasaki Y, Niu Y, Gohara S, Komatsu N, Shichijo S, Itoh K, Noguchi M
    • Journal Title

      Int J Oncol 34 (peer review)

      Pages: 529-536

    • Related Report
      2008 Final Research Report
  • [Journal Article] Capability of SART3_<109-118> peptide to induce cytotoxic T-lymphocytes from prostate cancer patients with HLA class I-A11, -A31, and -A33 alleles.2009

    • Author(s)
      Noguchi M, et al.
    • Journal Title

      Int J Oncol 34

      Pages: 529-536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dexamethasone did not suppress immune boosting by personalized peptide vaccination for advanced prostate cancer patients.2008

    • Author(s)
      Naito M, Itoh K, Komatsu N, Yamashita Y, Shirakusa T, Yamada A, Moriya F, Ayatuka H, Mohamed ES, Matsuoka K, Noguchi M
    • Journal Title

      Prostate 68 (peer review)

      Pages: 1753-1762

    • Related Report
      2008 Final Research Report
  • [Journal Article] A randomized clinical trial of suspension technique for improving early recovery of urinary continence after radical retropubic prostatectomy.2008

    • Author(s)
      Noguchi M, Kakuma T, Suekane S, Nakashima O, Mohamed ER, Matsuoka K
    • Journal Title

      BJU Int 102 (peer review)

      Pages: 958-963

    • Related Report
      2008 Final Research Report
  • [Journal Article] Dexamethasone did not suppress immune boosting by personalized peptide vaccination for advanced prostate cancer patients.2008

    • Author(s)
      Noguchi M, et al
    • Journal Title

      Prostate 68

      Pages: 1753-1762

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 癌特異的免疫療法を基盤としたホルモン不応性再燃前立腺癌に対する集学的治療2008

    • Author(s)
      野口正典, 他
    • Journal Title

      西日泌尿 70

      Pages: 230-235

    • NAID

      10026145799

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles.2007

    • Author(s)
      Naito N, Yoshihiro K, Ishihara Y, Noguchi M, Yamashita Y, Shirakusa T, Yamada A, Itoh K, Harada M
    • Journal Title

      Br J Cancer 97 (peer review)

      Pages: 1648-1654

    • Related Report
      2008 Final Research Report
  • [Journal Article] Identification of SART3-derived peptides having the potential to hlduce cancer-reactive cytotoxic T lymphocytes from prostate callcer patients with HLA-A3 supertype alleles2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      Cancer Immunol Immun 56

      Pages: 689-698

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of target antigens in specific immunotherapy for renal cellcarcinoma2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      J Urol 177

      Pages: 1157-1162

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Peptide Vaccine Candidates for Epithelial Cancer Patients with HLA-A3 Suee Alleles2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      J Immunother 30

      Pages: 274-281

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of APOBEC3G in kidney cells2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      Tissue antigens 69

      Pages: 95-98

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination therapy of personalized peptide vaccination and low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients:An analysis of prognostic factors in the treatment2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      Oncol Res 16

      Pages: 341-349

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunological evaluation of neoadjuvant peptide vaccination befbre radical prostatectomy for patients with localized prostate cancer2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      Prostate 67

      Pages: 933-942

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential levels of human leukocyte antigen-class I,multidrug-resistance 1,and androgen receptor expressions in untreated prostate cancer ceIls:the robustness of prostate cancer2007

    • Author(s)
      Noguchi M, et. al.
    • Journal Title

      Oncology Reports 18

      Pages: 343-346

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] HLA-A24陽性進行癌を対象としたテーラーメイド型ペプチドワクチン療法の第I相試験および継続投与試験2008

    • Author(s)
      寺崎 瑞彦, 野口 正典, 内藤 誠二, 植村 天受, 赤座 英之, 渋井 壮一郎, 藤巻 高光, 青木 友和, 伊東 恭悟, 峯田 寿裕, 梶原 浩司
    • Organizer
      第45回 日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-11-01
    • Related Report
      2008 Final Research Report
  • [Presentation] 再燃前立腺癌に対するペプチドワクチン・低用量エストラムスチン併用療法と常用量エストラムスチン単独療法とのランダム化臨床比較試験2008

    • Author(s)
      野口正典
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 再燃前立腺癌に対するペプチドワクチン・低用量エストラムスチン併用療法と常用量エストラムスチン単独療法とのランダム化臨床比較試験2008

    • Author(s)
      野口 正典, 末金 茂高, 守屋 普久子, 松岡 啓, 植村 天受, 那須 保友, 公文 裕巳, 山田 亮, 伊東 恭悟
    • Organizer
      第45回 日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] テーラーメイド癌ペプチドワクチン臨床試験の生存解析:475症例でのアップデート2008

    • Author(s)
      峯 孝志, 野口 正典, 藤堂 省, 柳本 泰明, 植村 天受, 山中 龍也, 嘉村 敏治, 岡 正朗, 奥野 清隆, 松本 和将, 山田 亮, 伊東 恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] HLA-A2、-A24患者に対するペプチドワクチンとしてのHLA-A3スーパータイプペプチドの可能性2008

    • Author(s)
      寺崎 康展, 牛 亜梅, 七條 茂樹, 小松 誠和, 野口 正典, 藤堂 省, 伊東 恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] HLA-A26前列腺癌患者およびHCV感染者に対するワクチン候補ペプチドの解析2008

    • Author(s)
      牛 亜梅, 寺崎 康展, 小松 誠和, 野口 正典, 七條 茂樹, 山田 亮, 伊東 恭悟
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for HLA-A2 positive patients with hormone refractory prostate cancer2008

    • Author(s)
      Noguchi M, Itoh K, Yamada A, Moriya F, Suekane S, Matsuoka K
    • Organizer
      25Th JAPAN-KOREA UROLOGICAL CONGRESS
    • Place of Presentation
      岡山
    • Year and Date
      2008-09-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for advanced cancer2008

    • Author(s)
      Noguchi M, Todo S, Yanagimoto H, Yamanaka R, Oka M, Matsumoto T, Mine T, Yamada A,Matsuoka K, Itoh K
    • Organizer
      UICC 2008 (International Union Against Cancer) World Cancer Congress
    • Place of Presentation
      ジュネーブ
    • Year and Date
      2008-08-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for advanced cancer2008

    • Author(s)
      Noguchi M
    • Organizer
      UICC 2008 (International Union Against Cancer) World Cancer Congress
    • Place of Presentation
      スイス(ジュネーブ)
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 2年以上の長期テーラーメイド型ペプチドワクチン療法を行った進行再燃前立腺癌患者の免疫学的検討2008

    • Author(s)
      野口正典, 末金茂高, 守屋普久子, 山田 亮, 伊東恭悟, 松岡 啓
    • Organizer
      第12回基盤的癌免疫研究会総会
    • Place of Presentation
      埼玉
    • Year and Date
      2008-07-02
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Phase I trial of personalized peptide vaccine for HLA-A24 positive patients with advanced cancer2008

    • Author(s)
      Terasaki1 M, Noguchi1 M, Naito S, Uemura H, Akaza H, Sibui S, Fujimaki T, Aoki T, Itoh K
    • Organizer
      ASCO 2008 (American Society of Clinical Oncology) Annual Meeting
    • Place of Presentation
      シカゴ
    • Year and Date
      2008-06-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for HLA-A2 positive patients with advanced cancer.2008

    • Author(s)
      Noguchi M, Todo S, Yanagimoto H, Yamanaka R, Kamura T, Matsumoto T, Mine T, Yamada A,Itoh K
    • Organizer
      ASCO 2008 (American Society of Clinical Oncology) Annual Meeting
    • Place of Presentation
      シカゴ
    • Year and Date
      2008-06-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Immunological and clinical effects of personalized peptide vaccine for HLA-A2 positive patients with advanced cancer2008

    • Author(s)
      Noguchi M
    • Organizer
      ASCO 2008 (American Society of clinical Oncology) Annual Meeting
    • Place of Presentation
      アメリカ(シカゴ)
    • Year and Date
      2008-06-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] A phase I trial of personalized peptide vaccination for cytokine-refractory metastatic renal cell carcinoma patients.2008

    • Author(s)
      Suekane S, Noguchi M, Komohara Y, Nishitani M, Niroh M, Honma S, Yamada A, Kanayama H, Itoh K, Matuoka K
    • Organizer
      第23回 EAU (European Association of Urology) Annual Meeting
    • Place of Presentation
      ミラノ
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Combination therapy of personalized peptide vaccination and low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients2008

    • Author(s)
      Noguchi M, Suekane S, Mohamed ER, Matsuoka K
    • Organizer
      第1回 ICDD (International Conference on Drug Design & Discovery)
    • Place of Presentation
      ドバイ
    • Year and Date
      2008-02-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 癌特異的免疫療法を基盤としたホルモン不応駐再燃前立腺癌に対する集学的治療2007

    • Author(s)
      野口 正典
    • Organizer
      第59回日本泌尿器科学会西日本総会
    • Place of Presentation
      松山
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 汎HLへ型テーラーメイド癌ペプチドワクチンの第1相臨床試験2007

    • Author(s)
      野口 正典
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] アーフーメイドペプチドワクチン多施設共同研究2007

    • Author(s)
      野口 正典
    • Organizer
      第20回バィオセラピィ学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2007-10-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前立腺癌に対する術前テーラーメイド型ペプチドワクチン療法の抗腫瘍効果ならびに免疫応答に関する検討2007

    • Author(s)
      野口 正典
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 前立腺癌に対するテーラーメイドペプチドワクチン療法の開発2007

    • Author(s)
      野口 正典
    • Organizer
      第95回日本泌尿器科学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-04-04
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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