• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of the evaluation method for the ejaculatory function and its application to pharmacotherapy and side effect analysis

Research Project

Project/Area Number 19591884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTohoku Pharmaceutical University

Principal Investigator

YONEZAWA Akihiko  Tohoku Pharmaceutical University, 薬学部, 准教授 (30167738)

Research Collaborator YOSHIZUMI Masaru  
ISE Shin-nosuke  
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsアンドロロジー / 射精障害 / 動物評価モデル / 創薬 / 副作用 / 前立腺肥大症治療薬 / 糖尿病 / 射精 / 機能評価 / 5-HT受容体subtype / 早漏 / dopamine受容体 / 射精障害治療薬 / 機能解析 / serotonin受容体
Research Abstract

The purpose of this study is the establishment of quantitative evaluation model for the ejaculatory function and its application to pharmacotherapy and side effect analysis. Obtained results by the support of KAKENNHI are as follows. 1) We succeeded for the establishment of rat model for the quantitative evaluation of the ejaculatory function, which is a method with the convenient and high reproducibility. 2) By using this model, we found the very powerful enhancing effect by the simultaneous administration of 5-HT_<2C> receptor agonist and D_2 receptor agonist on ejaculation. 3) In addition, this model was applied to analysis and prevention of ejaculatory disorder induced by the pharmacotherapy for benign prostatic hypertrophy and the diabetes mellitus.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (21 results) Remarks (2 results)

  • [Journal Article] Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats2009

    • Author(s)
      Aki hi ko Yonezawa, Masaru Yoshizumi, Shin-nosuke Ise, Chizuko Watanabe, Hirokazu Mizoguchi, Katsuo Furukawa, Hiromichi Tsuru, Yukio Kimura, Masahito Kawatani, Shinobu Sakurada
    • Journal Title

      Biomedical Research 30

      Pages: 71-78

    • NAID

      130004470740

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic actions of apomorphine and m-chlorophenylpiperazine on djaculation, but not penile erection in rats.2009

    • Author(s)
      Akihiko Yonezawa
    • Journal Title

      Biomed.Res. 30

      Pages: 71-78

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats2009

    • Author(s)
      Akihiko Yonezawa
    • Journal Title

      Int. J. Urol. 16

      Pages: 208-211

    • NAID

      10025196460

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of insulin replacement on ejaculatory dysfunction in streptozotocin-induced diabetic rats2008

    • Author(s)
      Akihiko Yonezawa, Manabu Ebiko, Masaru Yoshizumi, Shin-Nosuke Ise, Chizuko Watanabe, Hirokazu Mizoguchi, Yukio Kimura, Shinobu Sakurada
    • Journal Title

      International Journal of Urology 16

      Pages: 208-211

    • NAID

      10025196460

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 男性性機能:動物実験からの評価と問題点、射精機能評価のための動物実験2008

    • Author(s)
      米澤章彦、伊勢慎之介、木村行雄、櫻田忍
    • Journal Title

      アニテックス 20(1)

      Pages: 13-17

    • Related Report
      2009 Final Research Report
  • [Journal Article] Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats: Differential roles of 5-HT2 receptor subtypes2008

    • Author(s)
      Akihiko Yonezawa, Manabu Ebiko, Masaru Yoshizumi, Shin-Nosuke Ise, Chizuko Watanabe, Hirokazu Mizoguchi, Yukio Kimura, Shinobu Sakurada
    • Journal Title

      Pharmacology Biochemistry Behavior 88

      Pages: 367-373

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ejaculatory response induced by a 5-HT2 receptor agonist m-CPP in rats;Differential roles of 5-HT2 receptor subtypes2008

    • Author(s)
      Akihiko Yonezawa
    • Journal Title

      Pharmacol. Biochem. Behav 88

      Pages: 367-373

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集:男性性機能:動物実験からの評価と問題-射精機能評価のための動物実験-2008

    • Author(s)
      米澤 章彦
    • Journal Title

      アニテックス 20

      Pages: 13-17

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラットのspontaneous seminal emission発現における5-HT_2受容体サブタイプの役割2010

    • Author(s)
      萬谷優
    • Organizer
      第20回日本性機能学会東部総会
    • Place of Presentation
      東邦大学(東京)
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラットのspontaneous seminal emissionに及ぼすα1-アドレナリン受容体遮断薬連続投与の影響2010

    • Author(s)
      伊勢慎之介
    • Organizer
      第20回日本性機能学会東部総会
    • Place of Presentation
      東邦大学(東京)
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラットのspontaneous seminal emission発現における5-HT2受容体サブタイプの役割2010

    • Author(s)
      萬谷優、米澤章彦、善積克、渡辺千寿子、溝口広一、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第20回日本性機能学会東部総会
    • Related Report
      2009 Final Research Report
  • [Presentation] ラットのspontaneous seminal emissionに及ぼすα1-アドレナリン受容体遮断薬連続投与の影響2010

    • Author(s)
      伊勢慎之介、米澤章彦、萬谷優、渡辺千寿子、溝口広一、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第20回日本性機能学会東部総会
    • Related Report
      2009 Final Research Report
  • [Presentation] 櫻田忍性機能障害の研究と臨床における各分野での連携2009

    • Author(s)
      米澤章彦、木村行雄
    • Organizer
      第19回日本性機能学会東部総会
    • Related Report
      2009 Final Research Report
  • [Presentation] 性機能障害の研究と臨床における各分野での連携-基礎の立場から-2009

    • Author(s)
      米澤 章彦
    • Organizer
      第19回日本性機能学会東部総会
    • Place of Presentation
      長野
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット射精誘発モデルを用いたα-アドレナリン受容体サブタイプの機能解析2008

    • Author(s)
      米澤章彦、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第19回日本性機能学会学術総会
    • Related Report
      2009 Final Research Report
  • [Presentation] ラットのspontaneous seminal emissionを指標としたα1-アドレナリン受容体遮断薬の射精障害解析-受容体サブタイプの特定-2008

    • Author(s)
      伊勢慎之介、米澤章彦、善積克、蛯子学、渡辺千寿子、溝口広一、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第19回日本性機能学会学術総会
    • Related Report
      2009 Final Research Report
  • [Presentation] Apomorphineおよびm-CPP併用投与による射精機能増強効果-脳室内および脊髄腔内投与による解析-2008

    • Author(s)
      善積克、米澤章彦、伊勢慎之介、蛯子学、渡辺千寿子、溝口広一、木村行雄、櫻田忍
    • Organizer
      第19回日本性機能学会学術総会
    • Related Report
      2009 Final Research Report
  • [Presentation] I型糖尿病モデルラットの射精機能障害に対するインスリンの効果2008

    • Author(s)
      蛯子学、米澤章彦、善積克、伊勢慎之介、渡辺千寿子、溝口広一、岩崎雅弘、木村行雄、櫻田忍
    • Organizer
      第19回日本性機能学会学術総会
    • Related Report
      2009 Final Research Report
  • [Presentation] ラットのspontaneous seminal emissionに及ぼすα1-アドレナリン受容体遮断薬連続投与の影響2008

    • Author(s)
      伊勢慎之介、米澤章彦、善積克、蛯子学、渡辺千寿子、溝口広一、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第17回泌尿生殖器における信号物質の局在と役割に関する研究会
    • Related Report
      2009 Final Research Report
  • [Presentation] ラット射精誘発モデルを用いたα-アドレナリン受容体サブタイプの機能解析2008

    • Author(s)
      米澤 章彦
    • Organizer
      第19回日本性機能学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットのspontaneous seminal emissionを指標としたα1-アドレナリン受容体遮断薬の射精障害解析-受容体サブタイプの特定-2008

    • Author(s)
      伊勢 慎之介, 米澤 章彦
    • Organizer
      第19回日本性機能学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2008 Annual Research Report
  • [Presentation] Apomorphineおよびm-CPP併用投与による射精機能増強効果-脳室内および脊髄腔内投与による解析-2008

    • Author(s)
      善積 克, 米澤 章彦
    • Organizer
      第19回日本性機能学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2008 Annual Research Report
  • [Presentation] I型糖尿病モデルラットの射精機能障害に対するインスリンの効果2008

    • Author(s)
      蛯子 学, 米澤 章彦
    • Organizer
      第19回日本性機能学会学術総会
    • Place of Presentation
      秋田
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラットのspontaneous seminalemissionを指標としたα1-アドレナリン受容体遮断薬の射精障害解析2007

    • Author(s)
      伊勢慎之介、米澤章彦、善積克、蛯子学、渡辺千寿子、溝口広一、木村行雄、河谷正仁、櫻田忍
    • Organizer
      第18回日本性機能学会
    • Related Report
      2009 Final Research Report
  • [Presentation] Apomorphineおよびm-CPP併用投与による射精機能増強効果-ラット精嚢での機能評価-2007

    • Author(s)
      善積克、米澤章彦、伊勢慎之介、蛯子学、渡辺千寿子、溝口広一、木村行雄、櫻田忍
    • Organizer
      第18回日本性機能学会
    • Related Report
      2009 Final Research Report
  • [Presentation] Synergitic action of dopamine D2-like and 5-HT2C receptor agonists on the ejaculatory receptor in rats2007

    • Author(s)
      Masaru Yoshizumi, Akihiko Yonezawa, Manabu Ebiko, Shin-nosuke Ise, Chizuko Watanabe, Hirokazu Mizoguchi, Yukio Kimura, Shinobu Sakurada
    • Organizer
      1th BIENNIAL MEETING OF THE ASIA PACIFIC SOCIETY FOR SEXUAL MEDICINE
    • Place of Presentation
      Korea
    • Related Report
      2009 Final Research Report
  • [Presentation] ラットのSpontaneous seminal emissionを指標としたα1-アドレナリン受容体遮断薬の射精障害解析2007

    • Author(s)
      米澤 章彦
    • Organizer
      第18回日本性機能学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Apomorphineおよびm-CPP併用投与による射精機能増強効果-ラット精嚢での機能評価-2007

    • Author(s)
      米澤 章彦
    • Organizer
      第18回日本性機能学会
    • Place of Presentation
      岡山
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synergitic action of dopanune D2-like and 5-HT2C receptor agonists on theejaculatory response in rats2007

    • Author(s)
      Akihiko Yonezawa
    • Organizer
      11th BIENNIAL MEETING OF THE ASIA PACIFIC SOCIETY FOR SEXUAL MEDICINE
    • Place of Presentation
      Korea
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.tohoku-pharm.ac.jp/new/index.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tohoku-pharm.ac.jp/new/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi