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Development of medical treatment for sperm centrosomal dysfunction

Research Project

Project/Area Number 19591888
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

MURAKAMI Takashi  Tohoku University, 医学部, 教授 (20240666)

Co-Investigator(Kenkyū-buntansha) TERADA Yukihiro  東北大学, 病院, 准教授 (10260431)
YUKI Hiromitsu  東北大学, 大学院・医学系研究科, 助教 (60302121)
TAKAHASHI Aiko  東北大学, 病院, 技能補佐員 (30436125)
KITA Nobuyuki  滋賀医科大学, 医学部, 准教授 (20273419)
SHIMIZU Yoshihiko  滋賀医科大学, 医学部, 准教授 (50422887)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords精子中心体機能 / 精子星状体 / カルシウムイオノフォア / ICSI / IMSI / 顕微受精 / 精子中心体機能不全
Research Abstract

Fertilization arrest after intracytoplasmic sperm injection (ICSI) was observed in fertilization failure eggs at various stages of fertilization. Failures to complete fertilization following ICSI have shown that some cases are associated with sperm centrosomal dysfunction. Artificial oocyte activation by exposure to a calcium ionophore may escape the fertilization failure. Selecting sperm on the basis of midpiece morphology with the high magnification microscopy may improve the sperm aster formation rates. The injection of selected sperm bearing morphologically normal midpieces may contribute to improved expression of sperm centrosomal function, providing a positive effect on fertilization after ICSI.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Functional analyses of the sperm centrosome in human reproduction: implications for assisted reproductive technique.2007

    • Author(s)
      Terada Y.
    • Journal Title

      Soc Reprod Fertil Suppl 63

      Pages: 507-513

    • Related Report
      2009 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] I CSIの新たな戦略-IMSIによる形態学的に正常な中片部を持つ精子の選別-2008

    • Author(s)
      長谷川久隆・寺田幸弘・宇賀神智久・高橋藍子・早坂真一・立花眞仁・結城広光・村上節・八重樫伸生・岡村州博
    • Organizer
      第49回日本哺乳動物卵子学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-05-17
    • Related Report
      2009 Final Research Report
  • [Presentation] ICSIの新たな戦略-IMSIによる形態学的に正常な中片部を持つ精子の選別-2008

    • Author(s)
      長谷川久隆
    • Organizer
      第49回日本哺乳動物卵子学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-05-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 精子中心体機能発現異常-2007

    • Author(s)
      宇賀神智久・寺田幸弘・長谷川久隆・高橋藍子・結城広光・村上節・八重樫伸生・岡村州博
    • Organizer
      第39回精子研究会
    • Place of Presentation
      仙台
    • Year and Date
      2007-12-01
    • Related Report
      2009 Final Research Report
  • [Presentation] 精子中心体機能発現調節2007

    • Author(s)
      宇賀神智久
    • Organizer
      第39回精子研究会
    • Place of Presentation
      東北大学医学部5号館
    • Year and Date
      2007-12-01
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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