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Relation between alteration of DNA mismatch repair/tumor immunologyand sensitivities of anti-cancer drugs and hormone in endometrialcancer

Research Project

Project/Area Number 19591943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

SUSUMU Nobuyuki  Keio University, 医学部, 講師 (90206459)

Co-Investigator(Kenkyū-buntansha) BANNO Banno  慶應義塾大学, 医学部, 講師 (70265875)
Co-Investigator(Renkei-kenkyūsha) HIRASAWA Akira  慶應義塾大学, 医学部, 助教 (90296658)
SUGANO Kokichi  栃木県立がんセンター研究所, 室長 (00171124)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords婦人科腫瘍学 / 子宮体癌 / マイクロサテライト不安定性 / 腫瘍免疫 / 抗癌剤感受性 / 黄体ホルモン
Research Abstract

初期子宮体癌113例に対して妊孕性温存療法の高用量黄体ホルモン(MPA)療法を行った。病変消失率はG1腺癌で86.9%、異型増殖症で95.7%と好成績を示したが、再発率はともに約50%と高値であった。再発に影響する因子を多変量解析にて検討すると、遺伝性非ポリポーシス大腸癌関連腫瘍の家系内集積性とhMLH1蛋白発現減弱の2項目が高用量MPA療法後の再発に対する独立予後因子であることが初めて示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (72 results)

All 2009 2008 2007

All Journal Article (35 results) (of which Peer Reviewed: 24 results) Presentation (33 results) Book (4 results)

  • [Journal Article] Endometrial cancer as a familial tumor : Pathology and molecular carcinogenesis (Review)2009

    • Author(s)
      Banno K, Yanokura M, Kobayashi Y, Kawaguchi M, Nomura H, Hirasawa A, Susumu N, Aoki D
    • Journal Title

      Curr Genomics 10(2)

      Pages: 1-6

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of a correlation between the BRAF V600E mutation and abnormal DNA mismatch repair in patients with sporadic endometrial cancer2009

    • Author(s)
      Kawaguchi M, Yanokura M, Banno K, Kobayashi Y, Kuwabara Y, Kobayashi M, Nomura H, Hirasawa A, Susumu N, Aoki D
    • Journal Title

      Int J Oncol

    • Related Report
      2008 Final Research Report
  • [Journal Article] 婦人科がんの妊孕性温存手術-開腹手術-2009

    • Author(s)
      山上亘、進伸幸、津田浩史、藤井多久磨、青木大輔
    • Journal Title

      産婦人科の実際 58(3)

      Pages: 291-296

    • Related Report
      2008 Final Research Report
  • [Journal Article] Analysis of a correlation between the BRAF V600E mutation and abnormal DNA mismatch repair in patients with sporadicendometrial cancer.2009

    • Author(s)
      Kawaguchi M, et al.
    • Journal Title

      Int J Oncol (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Favourable prognosis with modified dosing of docetaxel and cisplatin in Japanese patients with ovarian cancer.2009

    • Author(s)
      Aoki D, et al.
    • Journal Title

      Anticancer Res 29

      Pages: 561-566

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endometrial cancer as a familial tumor : Pathology and molecular carcinogenesis. (Review)2009

    • Author(s)
      Banno K, et al.
    • Journal Title

      Curr Genomics 10(2)

      Pages: 1-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 婦人科がんの妊孕性温存手術-開腹手術-2009

    • Author(s)
      山上 亘, 他
    • Journal Title

      産婦人科の実際 58(3)

      Pages: 291-296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvant treatment of early-stage endometrial cancer : Which patient can benefit from chemotherapy?2008

    • Author(s)
      Susumu N, Sagae S, Udagawa Y. Reply to Michael H. R. Eichbaum, et al.
    • Journal Title

      Gynecol Oncol 109(3)

      Pages: 434-436

    • Related Report
      2008 Final Research Report
  • [Journal Article] Japanese Gynecologic Oncology Group. Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer : a Japanese Gynecologic Oncology Group study2008

    • Author(s)
      Susumu N, Sagae S, Udagawa Y, Niwa K, Kuramoto H, Satoh S, Kudo R
    • Journal Title

      Gynecol Oncol 108(1)

      Pages: 226-233

    • Related Report
      2008 Final Research Report
  • [Journal Article] 子宮がん患者へのインフォームドコンセント(IC)2008

    • Author(s)
      進伸幸、平沢晃、阪埜浩司、藤井多久磨、青木大輔
    • Journal Title

      臨床腫瘍プラクティス 4(4)

      Pages: 313-319

    • Related Report
      2008 Final Research Report
  • [Journal Article] 子宮体癌の術後化学療法-タキサンとプラチナの併用に関する新たなエビデンスの構築を目指して-2008

    • Author(s)
      青木大輔、進伸幸、野村弘行
    • Journal Title

      産婦人科の実際 57(13)

      Pages: 2129-2134

    • Related Report
      2008 Final Research Report
  • [Journal Article] Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate-and high-risk endometrial canser : a Japanese Gynecologic Oncology Group study2008

    • Author(s)
      Susumu N, et al.
    • Journal Title

      Gynecol Oncol 108(1)

      Pages: 226-233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply to Michael H. R. Eichbaum, et al, “Adjuvant treatment of early-stage endometrial cancer : Which patient can benefit from chemotherapy"2008

    • Author(s)
      Susumu N, et al.
    • Journal Title

      Gynecol Oncol 109(3)

      Pages: 434-436

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human monoclonal antibody for ovarian clear cell carcinoma-2, a human monoclonal antibody with antitumor activity against ovarian cancer cells that recognizes CA125-like antigen.2008

    • Author(s)
      Suzuki N, et al.
    • Journal Title

      Int J Gynecol Cancer 18(5)

      Pages: 996-1006

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Can ABCF2 protein expression predict the prognosis of uterine cancer?2008

    • Author(s)
      Nishimura S, et al.
    • Journal Title

      Br J Cancer 99

      Pages: 1651-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮がん患者へのインフォームドコンセント(IC)2008

    • Author(s)
      進 伸幸, 他
    • Journal Title

      臨床腫瘍プラクティス 4(4)

      Pages: 313-319

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮体癌の術後化学療法 -タキサンとプラチナの併用に関する新たなエビデンスの構築を目指して-2008

    • Author(s)
      青木大輔, 他
    • Journal Title

      産婦人科の実際 57(13)

      Pages: 2129-2134

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮体がん術後患者における骨密度の特徴に関する検討2008

    • Author(s)
      平沢 晃, 他
    • Journal Title

      Osteoporosis Japan 16(3)

      Pages: 57-59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸癌におけるエピジェネティックなCHFR遺伝子の不活化とタキサン製剤感受性との関連2008

    • Author(s)
      阪埜浩司, 他
    • Journal Title

      産婦人科の実際 57(7)

      Pages: 1189-1194

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laboratory Practice 病理 液状処理細胞診検査の新しい試み 子宮頸部2008

    • Author(s)
      照井仁美, 他
    • Journal Title

      検査と技術 36(11)

      Pages: 1262-1265

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate and high risk endometrial cancer.A Japanese Gynecologic Oncology2008

    • Author(s)
      N. Susumu, et. al.
    • Journal Title

      Group Study 108

      Pages: 226-233

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reply to Michael H.R. Eichbaum, et. al.:Adjuvant treatment ofearly-stage endometrial cancer:Which patient can benefit fromchemotherapy2008

    • Author(s)
      N. Susumu, et. al.
    • Journal Title

      Gynecol Oncol 109

      Pages: 434-436

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A synthetic retinoid, TAC-101(4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid), plus cisplatin:potential new therapy for ovarian clear cell adenocarcinoma2008

    • Author(s)
      S. Ezawa, et. al.
    • Journal Title

      Gynecol Oncol 108(3)

      Pages: 627-631

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human monoclonal antibody for ovarian clear cell carcinoma-2,ahuman monoclonal antibody with antitumor activity against ovariancancer cells that recognizes CA125-like antigen2008

    • Author(s)
      N. Suzuki, et. al.
    • Journal Title

      Int J Gynecol Cancer

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes2007

    • Author(s)
      Banno K, Yanokura M, Kawaguchi M, Kuwabara Y, Akiyoshi J, Kobayashi Y, Iwata T, Hirasawa A, Fujii T, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Int J Oncol 31(4)

      Pages: 713-720

    • Related Report
      2008 Final Research Report
  • [Journal Article] Use of the collagen gel droplet embedded drug sensitivity test to determine drug sensitivity against ovarian mature cystic teratoma with malignant transformation to adenocarcinoma : a case report2007

    • Author(s)
      Yamagami W, Banno K, Kawaguchi M, Yanokura M, Kuwabara Y, Hirao N, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Chemotherapy 53(2)

      Pages: 137-141

    • Related Report
      2008 Final Research Report
  • [Journal Article] Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer2007

    • Author(s)
      Yanokura M, Banno K, Kawaguchi M, Hirao N, Hirasawa A, Susumu N, Tsukazaki K, Aoki D
    • Journal Title

      Oncol Rep 17(1)

      Pages: 41-48

    • Related Report
      2008 Final Research Report
  • [Journal Article] 家系内癌集積性を有する子宮体癌症例におけるMMR遺伝子の生殖細胞変異解析2007

    • Author(s)
      阪埜浩司、進伸幸、矢野倉恵、平沢晃、塚崎克己、青木大輔、三木義男、野澤志朗
    • Journal Title

      家族性腫瘍 7(1)

    • NAID

      130007540979

    • Related Report
      2008 Final Research Report
  • [Journal Article] Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanes2007

    • Author(s)
      K. Banno, et. al.
    • Journal Title

      Int J Oncol 34(4)

      Pages: 713-720

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of aberrant DNA hypermethylation of CHFR with sensitivity to taxanes in endometrial cancer2007

    • Author(s)
      M. Yanokura, et. al.
    • Journal Title

      Oncol Rep 17

      Pages: 41-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific expression of hepatocyte nuclear actor-10 in the ovarianclear cell adenocarcinoma and its application to cytological diagnosis2007

    • Author(s)
      A. Higashiguchi, et. al.
    • Journal Title

      Cancer Sci 98(3)

      Pages: 387-391

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of the Collagen Gel Droplet Embedded Drug Sensitivity Test to Determine Drug Sensitivity against Ovarian Mature Cystic Teratoma with Malignant Transformation to Adenocarcinoma:A case report2007

    • Author(s)
      W. Ymagami, et. al.
    • Journal Title

      Chemotherapy 53(2)

      Pages: 137-141

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of pulmonary type of ovarian small cell carcinoma2007

    • Author(s)
      N. Suzuki, et. al.
    • Journal Title

      J Obstet Gynaecol Res 33(2)

      Pages: 203-206

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of NEY3(Plasma Membrane-Associated Silidase)in Clear Cell Adenocarcinoma of the Ovary:Its Relationship with T Factor of pTNM Classification2007

    • Author(s)
      H. Nomura, et. al.
    • Journal Title

      Oncol Rep 16

      Pages: 289-297

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological and therapeutic significance of MUCI with sialoglycans in clear cell adenocarcinoma of the ovary2007

    • Author(s)
      Y. Tamada, et. al.
    • Journal Title

      Cancer Sci 98(10)

      Pages: 1586-1591

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再発子宮体癌治療における白金製剤反復投与の意義とplutinum free intervalに関する検討2008

    • Author(s)
      市川義一、進伸幸、末盛友浩、野村弘行、片岡史夫、平沢晃、冨永英一郎、津田浩史、阪埜浩司、青木大輔
    • Organizer
      第46回日本癌治療学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] エピジェネティック異常により発現抑制される子宮体がん関連がん遺伝子のMPA療法による役割2008

    • Author(s)
      鶴田智彦、井本逸勢、平沢晃、小崎健一、阪埜浩司、進伸幸、青木大輔
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Outcome of fertility-preserving MPA therapy for young patients with atypical endometrial hyperplasia complex or different grades of endometrial cancer2008

    • Author(s)
      Susumu N, Hirasawa A, Ichikawa Y, Suemori T, Kobayashi Y, Nomura H, Kataoka F, Tominaga E, Suzuki A, Tsuda H, Banno K, Aoki D
    • Organizer
      The XIth International Gynecologic Cancer Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-10-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Outcome of fertility-preserving MPA therapy for young patients with atypical endometrial hyperplasia complex or different grades of endometrial cancer.2008

    • Author(s)
      Susumu N, et al.
    • Organizer
      The Xlth International Gynecologic Cancer Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-10-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Association between expression of aurora-a and anticancer drug sensitivity in endometrial cancer2008

    • Author(s)
      Banno K, Yanokura M, Kobayashi Y, Kuwabara Y, Susumu N, Tsukazaki K, Aoki D
    • Organizer
      The XIth International Gynecologic Cancer Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Association between expression of aurora-a and anticancer drug sensitivity in endometrial cancer.2008

    • Author(s)
      Banno K, et al.
    • Organizer
      The Xlth International Gynecologic Cancer Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子宮内膜癌の発ガンメカニズム : オーバービュー2008

    • Author(s)
      進伸幸、平沢晃、阪埜浩司、青木大輔
    • Organizer
      第40回日本臨床分子形態学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-10-03
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] M期チェックポイントCHFR遺伝子siRNAによる子宮癌細胞の抗癌剤感受性の変化2008

    • Author(s)
      阪埜浩司、矢野倉恵、小林佑介、秋好順子、桑原佳子、平沢晃、進伸幸、塚崎克己、青木大輔
    • Organizer
      第7回日本婦人科がん分子標的研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 分子標的薬を用いた治験の実際-当院における医師主導治験実施体制の整備を中心に-2008

    • Author(s)
      進 伸幸, 他
    • Organizer
      第7回日本婦人科がん分子標的研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 診断に苦慮した子宮原発の髄外形質細胞腫の一例2008

    • Author(s)
      末盛友浩, 他
    • Organizer
      第44回日本婦人科腫瘍学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-07-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 若年子宮体癌類内膜癌G2症例4例の妊よう性温存黄体ホルモン療法2008

    • Author(s)
      秋好順子、進伸幸、小林佑介、市川義一、末盛友浩、野村弘行、片岡史夫、平沢晃、鈴木淳、阪埜浩司、青木大輔、吉村泰典
    • Organizer
      第115回日本産科婦人科学会関東連合地方部会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 若年子宮体癌類内膜癌G2症例4例の妊よう性温存黄体ホルモン療法2008

    • Author(s)
      秋好順子, 他
    • Organizer
      第115回日本産科婦人科学会 関東連合地方部会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 子宮体癌における腹腔細胞診の意義2008

    • Author(s)
      冨永英一郎, 他
    • Organizer
      第49回日本臨床細胞学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 若年子宮体癌の高用量黄体ホルモン療法の治療終了時期判定に有用な2色FISH法2008

    • Author(s)
      進伸幸、市川義一、末盛友浩、山上亘、野村弘行、片岡史夫、平沢晃、冨永英一郎、阪埜浩司、鈴木淳、青木大輔、吉村泰典
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 子宮体癌における分裂期キナーゼAurora-Aの発現と抗癌剤感受性との関連2008

    • Author(s)
      小林佑介、阪埜浩司、矢野倉恵、秋好順子、樋野牧子、桑原佳子、進伸幸、塚崎克己、青木大輔、吉村泰典
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 塩酸イリノテカン個別化治療の確立を目指したUGTIA1遺伝子多型解析2008

    • Author(s)
      平沢 晃, 他
    • Organizer
      第60回日本産科婦人科学会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cyclooxygenase-2 expression andintra-tumor cell infiltrating CD8-positive lymphocytes (ITCIL) are associated with recurrence and prognosis in advanced endometrial cancer2007

    • Author(s)
      Suemori T, Susumu N, Tsuruta T, Ichikawa Y , Nomura H, Kataoka F, Hirasawa A, Tominaga E, Banno K, Suzuki A, Daisuke A
    • Organizer
      International Meeting of the European Society of Gynaecological Oncology
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of Prognotic risk factors among patients with early endmetrial cancer after fertility-preserving high-dose MPA (Medroxy-Progesteron acetate) therapy2007

    • Author(s)
      Ichikawa Y, Susumu N, Tsuruta T, Nomura H, Kataoka F, Hirasawa A, Tominaga E, Banno K, Suzuki A, Daisuke A
    • Organizer
      International Meeting of the European Society of Gynaecological Oncology
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of prognostic risk factors among patients with early endometrial cancer after fertility-preserving high-dose MPA therapy2007

    • Author(s)
      Y. lchikawa, et. al.
    • Organizer
      The XVth European Society of Gynaecol Oncology
    • Place of Presentation
      Berlin,German
    • Year and Date
      2007-10-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮体癌における高用量MPA療法の効果と再発危険因子の解析2007

    • Author(s)
      市川義一、進伸幸、鶴田智彦、末盛友浩、野村弘行、片岡史夫、平沢晃、冨永英一郎、阪埜浩司、鈴木淳、青木大輔
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-25
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 進行子宮体癌の再発・予後因子としてのCOX-2とCD8陽性リンパ球についての研究2007

    • Author(s)
      末盛 友浩, 他
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Expression of a mitotic kinase, aurora-a, affects taxane sensitivity in endometrial cancer2007

    • Author(s)
      Yanokura M, Banno K, Susumu N, Kuwabara Y, Hirasawa A, Tsukazaki K, Aoki D
    • Organizer
      AOCOG (Asian and Oceanic Congress of Obsterics and Gynaecology)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-09-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 再発子宮癌における腫瘍マーカー測定の意義に関する検討2007

    • Author(s)
      鶴田智彦、進伸幸、市川義一、野村弘行、平沢晃、玉田裕、冨永英一郎、阪埜浩司、鈴木淳、青木大輔
    • Organizer
      第42回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 家族性腫瘍としての子宮体癌-その病態と臨床的特徴について2007

    • Author(s)
      阪埜浩司、進伸幸、平沢晃、山上亘、矢野倉恵、管野康吉、三木善男、青木大輔
    • Organizer
      第13回日本家族性腫瘍学会学術集会
    • Place of Presentation
      高知
    • Year and Date
      2007-06-15
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 子宮体癌における術前腫瘍マーカー測定の意義2007

    • Author(s)
      鶴田 智彦, 他
    • Organizer
      第113回日本産科婦人科学会関東連合地方部会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] マイクロサテライト不安定性(MSI)陽性子宮体癌におけるフレームシフト変異標的遺伝子の解析2007

    • Author(s)
      阪埜 浩司, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮体癌における妊孕性温存高用量MPA療法の予後解析2007

    • Author(s)
      進伸幸、市川義一、末盛友浩、野村弘行、平沢晃、玉田裕、阪埜浩司、鈴木淳、塚崎克己、青木大輔、吉村泰典
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] マイクロサテライト不安定性(MSI)陽性子宮体癌におけるフレームシフト変異標的遺伝子の解析2007

    • Author(s)
      阪埜浩司、矢野倉恵、進伸幸、桑原佳子、平沢晃、塚崎克己、菅野康吉、青木大輔、吉村泰典
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 子宮体癌における妊孕性温存高容量MPA療法の予後解析2007

    • Author(s)
      進 伸幸, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 子宮体癌の大網転移に影響する臨床病理学的因子の検討2007

    • Author(s)
      市川 義一, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] COX-2発現量およびCD8陽性リンパ球数が進行期子宮体癌の予後に与える影響2007

    • Author(s)
      末盛 友浩, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 婦人科悪性腫瘍におけるHNF1B(hepatocyto nuclear factor-1b)の発現とその意義に関する検討2007

    • Author(s)
      東口 敦司, 他
    • Organizer
      第59回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] COX-2発現量およびCD8陽性リンパ球数が進行期子宮体癌の予後に与える影響2007

    • Author(s)
      末盛友浩、進伸幸、矢野倉恵、市川義一、野村弘行、平沢晃、玉田裕、阪埜浩司、鈴木淳、塚崎克己、青木大輔、吉村泰典
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2007-04-15
    • Related Report
      2008 Final Research Report
  • [Book] 子宮内膜病変診断法としての2色FISH法の治療への応用 -若年子宮体癌に対する妊孕性温存療法治療終了時期判定-第33回組織細胞化学講習会組織細胞化学20082008

    • Author(s)
      進伸幸、片岡史夫、平沢晃、阪埜浩司、青木大輔
    • Publisher
      日本組織細胞化学編中西印刷京都
    • Related Report
      2008 Final Research Report
  • [Book] 進行・再発子宮体癌の標的病変に対するプロゲステロン療法婦人科がん標準化学療法の実際2008

    • Author(s)
      進伸幸、市川義一、末盛友浩、平沢晃、阪埜浩司、青木大輔
    • Publisher
      金原出版東京
    • Related Report
      2008 Final Research Report
  • [Book] 子宮内膜病変診断法としての2色FISH法の治療への応用-若年子宮体癌に対する妊孕性温存療法治療終了時期判定-2008

    • Author(s)
      進 伸幸, 他
    • Publisher
      日本組織細胞化学会 中西印刷
    • Related Report
      2008 Annual Research Report
  • [Book] 婦人科がん標準化学療法の実際進行・再発子宮体癌の標的病変に対するプロゲステロン療法2008

    • Author(s)
      進 伸幸, 他
    • Publisher
      金原出版
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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