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Seasonal changes in antigen-specific T-helper clone sizes and their memory functions in patients with Japanese cedar pollinosis

Research Project

Project/Area Number 19591957
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

HORIGUCHI Shigetoshi  Chiba University, 大学院・医学研究院, 講師 (30293468)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Yoshitaka  千葉大学, 大学院・医学研究院, 教授 (40169157)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアレルギー / ぜんそく / アレルギー・ぜんそく / 免疫学 / 免疫記憶 / メモリーT細胞 / 鼻アレルギー / Th2 細胞 / 花粉症 / Th2細胞 / 記憶免疫
Research Abstract

Allergic rhinitis (AR) is a typical type I allergic disease that occurs through the induction of allergen-specific effector T cells. Once established, new effector T cells derive mostly from memory T cells that are capable of surviving for extended periods, although the mechanisms by which these memory functions are maintained have not yet been clarified. In particular, the exact life-span of memory T cells is still not well understood.
We compared the seasonal changes in memory T-helper type 2 (Th2) between pollinosis and perennial allergic subjects. The Japanese cedar-specific IL-4-producing Th2 memory cells increased during the pollen season and decreased during the off-season. However, more than 60% of the cedar-specific memory Th2 cells survived up to 8 months after the pollen season. While pollen-specific Th cells decreased after pollen exposure, their memory functions continued. Memory clone size maintenance therefore requires repetitive antigen irritation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (1 results)

  • [Journal Article] 成人に対する舌下免疫療法2010

    • Author(s)
      堀口茂俊
    • Journal Title

      アレルギーの臨床 30巻

      Pages: 225-230

    • Related Report
      2009 Final Research Report
  • [Journal Article] スギ特異的免疫療法はヒノキ花粉にも有効ですか2010

    • Author(s)
      堀口茂俊
    • Journal Title

      アレルギーの臨床 29巻

      Pages: 184-186

    • Related Report
      2009 Final Research Report
  • [Journal Article] 成人に対する舌下免疫療法2010

    • Author(s)
      堀口茂俊
    • Journal Title

      アレルギーの臨床 30-3

      Pages: 225-230

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 花粉症の免疫治療の現状2009

    • Author(s)
      堀口茂俊
    • Journal Title

      Medical Science Digest 35巻

      Pages: 19-21

    • Related Report
      2009 Final Research Report
  • [Journal Article] アレルギー性鼻炎のメジャーアレルゲンについて2009

    • Author(s)
      堀口茂俊
    • Journal Title

      JOHNS 25巻

      Pages: 301-303

    • Related Report
      2009 Final Research Report
  • [Journal Article] スギ特異的免疫療法はヒノキ花粉症にも有効ですか?(Q&A)2009

    • Author(s)
      堀口茂俊
    • Journal Title

      アレルギーの臨床 29-2

      Pages: 184-186

    • Related Report
      2009 Annual Research Report
  • [Journal Article] アレルギー性鼻炎のメジャー・アレルゲンについて教えてください(Q&A)2009

    • Author(s)
      堀口茂俊
    • Journal Title

      JOHNS 25-3

      Pages: 301-303

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 花粉症の免疫治療の現状2009

    • Author(s)
      堀口茂俊
    • Journal Title

      Medical Science Digest 35

      Pages: 19-21

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Seasonal changes in antigen-specific T-helper clone sizes in patients with Japanese cedar pollinosis : a 2-year study2008

    • Author(s)
      Horiguchi S, Tanaka Y, Uchida T, Chazono H, Okawa T, Sakurai D, Okamoto Y.
    • Journal Title

      Clin Exp Allergy 38(3)

      Pages: 405-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis2008

    • Author(s)
      Horiguchi S, Okamoto Y, Yonekura S, Okawa T, Yamamoto H, Kunii N, Sakurai D, Fujimura T, Nakazawa K, Yasueda H.
    • Journal Title

      Int Arch Allergy Immunol. 146(1)

      Pages: 76-84

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lowered effectiveness of immunotherapy for cypress pollinosis by using Japanese cedar pollen extract2008

    • Author(s)
      Horiguchi S, Okamoto Y, Yonekura S, Okawa T, Kunii N, Yamamoto H, Sakurai D, Hanazawa T.
    • Journal Title

      Arerugi 57(5)

      Pages: 558-61

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A randomized controled trial of subhngual immunotherapy for Japanese cedar pollinosis.2008

    • Author(s)
      Horiguchi s
    • Journal Title

      Int Arch Allergy Immunol. 146

      Pages: 76-84

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal changes in antigen-specific T-helper clone sizes in patients with Japanese cedar pollinosis: a 2-years study.2008

    • Author(s)
      Horiguchi S
    • Journal Title

      Clin Exp Allergy 38

      Pages: 405-412

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] アレルギーの感作成立=発症なのか? アレルギー性鼻炎に関して (シンポジウム)2009

    • Author(s)
      堀口茂俊
    • Organizer
      第59回日本アレルギー学会 秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] アレルギーの感作成立=発症なのか?アレルギー性鼻炎に関して2009

    • Author(s)
      堀口茂俊
    • Organizer
      第59回日本アレルギー学会 秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 免疫療法の位置づけと展望 : スギ花粉症に対して (シンポジウム)2009

    • Author(s)
      堀口茂俊
    • Organizer
      第59回日本アレルギー学会 秋季学術大会
    • Place of Presentation
      秋田市
    • Year and Date
      2009-10-27
    • Related Report
      2009 Final Research Report
  • [Presentation] アレルギー性鼻炎及び頭頸部癌における抗原特異的T細胞の検討と臨床への応用2008

    • Author(s)
      堀口茂俊
    • Organizer
      第47回日本鼻科学会学会賞記念講演
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-09-25
    • Related Report
      2009 Final Research Report
  • [Presentation] アレルギー性鼻炎及び頭頸部癌における抗原特異的T細胞の検討と臨床への応用2008

    • Author(s)
      堀口茂俊
    • Organizer
      第47回日本鼻科学会学会賞記念講演
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Book] アレルギー疾患の治療2010

    • Author(s)
      堀口茂俊
    • Total Pages
      415
    • Publisher
      中外医薬社
    • Related Report
      2009 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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