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frontier treatment for anosmia using olfactory stem cell

Research Project

Project/Area Number 19591986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagoya City University

Principal Investigator

HAMAJIMA Yuki  Nagoya City University, 大学院・医学研究科, 助教 (30343403)

Co-Investigator(Kenkyū-buntansha) HIDA Hideki  名古屋市立大学, 大学院・医学研究科, 教授 (00305525)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords嗅覚障害 / 組織幹細胞 / 嗅上皮細胞
Research Abstract

胎児マウス嗅上皮粘膜より、組織幹細胞を取り出した。浮遊細胞は球状なneuro-sphere を形成し、12ヶ月以上継代することが出来た。マウス骨髄からも同様にsphereを形成する培養細胞が分離できたが、2ヶ月程すると、細胞はアポトーシスを起こし、消失していったのに対し、鼻粘膜由来の細胞は15ヶ月継代することができた。これらの細胞からRNA を抽出し、RT-PCRにて神経系マーカーの発現をみると、Musashi1、Nestin、などの神経幹細胞を示唆する遺伝子の発現を認めた

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (1 results)

  • [Journal Article] 小児気管支異物摘出における工夫2009

    • Author(s)
      森田真理、濱島有喜、渡邉暢浩、村上信五
    • Journal Title

      30(1)

      Pages: 42-46

    • NAID

      10024844545

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Directed differentiation of mouse cochlear neural progenitors in vitro2008

    • Author(s)
      Lin J, Feng L, Hamajima Y, Komori M, Burns TC, Fukudome S, Anderson J, Wang D, Verfaillie CM, Low WC.
    • Journal Title

      Am J Physiol Cell Physiol 296(3)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Type and severity of patulous Eustachian tube Nakazawa2008

    • Author(s)
      M, Inagaki A, Hamajima Y, et.al.
    • Journal Title

      Nagoya med 49

      Pages: 167-178

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Id1 in acquired middle ear cholesteatoma2008

    • Author(s)
      Zhang Q, Hamajima Y, Zhang Q, Lin J
    • Journal Title

      Arch Otolaryngology-HNS 134(3)

      Pages: 306-310

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【異物 初期対応から摘出まで】耳鼻咽喉科領域の異物2008

    • Author(s)
      渡邉暢浩, 濱島有喜, 稲垣彰 ENTONI
    • Journal Title

      摘出術の実際 96

      Pages: 15-21

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Directed differentiation of mouse cochlear neural progenitors in vitro.2008

    • Author(s)
      Lin J
    • Journal Title

      Am J Physiol Cell Physiol. 296(3)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Idl in acquired middle ear cholesteatoma2008

    • Author(s)
      Zhang Q
    • Journal Title

      Arch Otolaryngology-HNS 134(3)

      Pages: 306-310

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase in dopaminergic neurons from mouse embryonic stem cell-derived neural progenitor/stem cells is mediated by hypoxia inducible factor-lalpha.2008

    • Author(s)
      Kim TS
    • Journal Title

      J Neurosci RES 86(11)

      Pages: 2353-2362

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cochlear stem cells/progenitors and degenerative hearing disorders2007

    • Author(s)
      Lin J, Feng L, Fukudome S, Hamajima Y, Huang T, Levine S
    • Journal Title

      Curr Med Chem 14(27)

      Pages: 2937-43

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Syk is associated with nasal polyp in patients with allergic rhinitis2007

    • Author(s)
      Hamajima Y, Fujieda S, Subaga H, Yamada T, Moribe K, Watanabe N, Murakami S
    • Journal Title

      Auris Nasas Larynx 34(1)

      Pages: 49-56

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Id1 Induces the Proliferation of Cochlear Sensory epithelial cells via the NF-кB/Cyclin D1 Pathway in vitro2007

    • Author(s)
      Ozeki M, Hamajima Y, Feng L, Ondrey F, Schlentz E, Lin J
    • Journal Title

      J neurosci Res . Feb 15 85(3)

      Pages: 515-24

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pneumococcal Peptidoglycan-Polysaccharides Induce the Expression of IL-8 in Airway Epithelial Cells via NF-κB, NF-IL6, and/or AP-1 dependent2007

    • Author(s)
      Tsuchiya K, Toyama K, Tsuprun V, Hamajima Y, Kim Y, Ondrey F, Lin J
    • Journal Title

      Laryngoscope, Jan 117(1)

      Pages: 86-91

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症における第二世代抗ヒスタミン薬の有用性の検討2007

    • Author(s)
      濱島有喜、中村善久、大野伸晃、大橋卓、服部綾、高木繁、村上信五
    • Journal Title

      診療と新薬 44(2)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球中耳炎update2007

    • Author(s)
      渡邉暢浩、濱島有喜、中村善久、村上信五
    • Journal Title

      ENTONI 73

      Pages: 51-57

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症における第二世代抗ヒスタミン薬の臨床効果2007

    • Author(s)
      藤枝重治、山田武千代、濱島有喜
    • Journal Title

      他 日鼻誌 46(1)

      Pages: 18-28

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] マクロライド系抗菌薬クラリスロマイシンの鼻茸への移行性2007

    • Author(s)
      羽柴基之、濱島有喜
    • Journal Title

      他耳展 50

      Pages: 89-94

    • NAID

      130003975413

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球中耳炎update 3.乳突洞削開術と鼓室形成術2007

    • Author(s)
      渡邉暢浩、濱島有喜、中村善久、村上信五
    • Journal Title

      ENTONI 73

      Pages: 51-57

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症における第二世代抗ヒスタミン薬の有用性の比較検討2007

    • Author(s)
      濱島有喜、中村善久
    • Journal Title

      他診療と新薬 44(2)

      Pages: 177-186

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症に対する第二世代抗ヒスタミン薬の効果2007

    • Author(s)
      大野伸晃 濱島有喜 大橋卓 村上信五
    • Journal Title

      耳鼻咽喉科免疫アレルギー 25巻2号

      Pages: 213-214

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【花粉症治療のアップデート】受療行動を高める薬剤選択2007

    • Author(s)
      今野昭義, 榎本雅夫, 濱島有喜, 久保伸夫MEDICO
    • Journal Title

      38巻2号

      Pages: 51-62

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中耳杯細胞分化の制御因子2007

    • Author(s)
      中村善久, 濱島有喜, 村上信五
    • Journal Title

      耳鼻咽喉科免疫アレルギー 25巻2号

      Pages: 71-72

    • NAID

      10021297295

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 3DAccu-i-tomo(小照射野コーンビームCT)の耳科手術支援機器として利用2007

    • Author(s)
      村上信五, 濱島有喜, 稲垣彰
    • Journal Title

      耳鼻咽喉科展望 50巻5号

      Pages: 359-361

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Syk is associated with nasal polyp in patients with allergic rhinitis2007

    • Author(s)
      Hamajima Y
    • Journal Title

      Auris Nasus Larynx 34

      Pages: 49-56

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumococcal Peptidoglycan-polysaccharides induce the Expressi on of Interlukin-8 in Airway Epithelial Cells by way of Nuclear Factor interleukin-6, or Activation Protein-1 dependent Mechanisms2007

    • Author(s)
      Tsuchiya K
    • Journal Title

      Laryngoscope 117

      Pages: 86-91

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症における第2世代抗ヒスタミン薬の有用性の比較検討2007

    • Author(s)
      濱島有喜
    • Journal Title

      診療と新薬 44(2)

      Pages: 177-186

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 尋常性乾癬における扁桃腺摘出術の効果2007

    • Author(s)
      濱島有喜
    • Organizer
      第20回日本口腔・咽頭科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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