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Evaluating postsurgical swallowing disturbance and function in patients with head and neck cance

Research Project

Project/Area Number 19591988
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionSaitama Medical University

Principal Investigator

HIGO Ryuzaburo (HIGO Ryuuzaburou)  Saitama Medical University, 医学部, 准教授 (10301110)

Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords頭頸部癌 / 嚥下機能 / 嚥下圧測定 / 手術 / Videofluorography / 嚥下障害 / 頭頸部腫瘍 / VF
Research Abstract

Objectives : Head and neck cancer patients who undergo tumor resection and reconstruction often exhibit swallowing disturbance after surgery. Swallowing disturbance is usually evaluated by videofluorography (VF) ; however, this method provides an inferior qualitative analysis. We examined the usefulness of manometry in obtaining quantitative data on swallowing function in patients after head and neck cancer resection and reconstruction, which may allow for us to lead to new reconstruction methods with recovery of swallowing function.
Methods : We investigated postsurgical swallowing function using a combination of VF and manometry in patients with head and neck cancer, who underwent tumor resection and reconstruction. Oropharyngeal swallowing pressure, hypopharyngeal swallowing pressure, and relaxation time of upper esophageal sphincer (UES) were measured at the same time as the VF examination.
Results and discussion : Partial resection of the mandible without reconstruction for the defe … More ct of the bony segment had a negative effect upon oropharyngeal swallowing pressure. Hypopharyngeal swallowing pressure was normal unless the resection area involved the hypopharynx. A combination of VF and manometry revealed that mandibular bone partial resection resulted in disturbed elevation of the larynx while pharyngeal swallowing pressure decreases in those patients who do not undergo bony segment reconstruction. The tongue, including the base of the tongue, should be set in a closed space so that pharyngeal swallowing pressure does not release. In patients with oropharyngeal cancer patients, findings from the pharyngeal stage in the VF examination were well correlated to the results of oropharyngeal swallowing pressure, but hypopharyngeal swallowing pressure and UES relaxation were not correlated to the results of the VF examination. Patients who exhibited a decrease in both oropharyngeal and hypopharyngeal swallowing pressure were still restricted to a liquid diet a year after surgery, while patients who exhibited hypopharyngeal swallowing pressure could orally ingest a soft or normal diet soon after surgery. Thus patients who maintained hypopharyngeal swallowing pressure generally were able to eat normally soon after surgery, even if the oropharyngeal swallowing pressure was disturbed. Our study, using VF and manometry together, suggested that maintenance of hypopharyngeal swallowing function in patients with oropharyngeal cancer is important in the restoration of oral food intake. In patients with hypopharyngeal cancer patiens, we examined swallowing function after partial resection of the hypopharynx. To keep function of the tongue base, which resulted in maintaining oropharyngeal swallowing pressure, is important for hypopharyngeal cancer patiens after partial resection of the hypopharynx. Less

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008 2007

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (14 results) Book (2 results)

  • [Journal Article] 神経・筋疾患における摂食・嚥下障害2011

    • Author(s)
      肥後隆三郎
    • Journal Title

      口腔・咽頭 24

      Pages: 17-20

    • NAID

      10028176369

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Manometric assessment of pharyngeal swallowing pressure after mandibular reconstruction.2011

    • Author(s)
      Higo Ryuzaburo
    • Journal Title

      Eur Arch Otorhinolaryngol

      Volume: (on line first)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経・筋疾患における摂食・嚥下障害2011

    • Author(s)
      肥後隆三郎
    • Journal Title

      口腔・咽頭

      Volume: 24 Pages: 17-20

    • NAID

      10028176369

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manometric assessment of pharyngeal swallowing pressure after mandibular reconstruction.2010

    • Author(s)
      Higo R, Nakahira M, Sugasawa M, Nakatsuka T
    • Journal Title

      Eur Arch Otorhinolaryngol. (in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 転移性有棘細胞癌に対しTS-1単独投与によりCRが得られた1例2009

    • Author(s)
      中村元樹,田口理史,山本明史,肥後隆三郎
    • Journal Title

      臨床皮膚科 63

      Pages: 965-968

    • Related Report
      2010 Final Research Report
  • [Journal Article] 埼玉医科大学国際医療センター皮膚腫瘍科・皮膚科2009

    • Author(s)
      中村元樹(埼玉医科大学国際医療センター皮膚腫瘍科・皮膚科), 田口理史, 山本明史, 肥後隆三郎
    • Journal Title

      臨床皮膚科 63巻12号

      Pages: 965-968

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article]2009

    • Author(s)
      Ryuzaburo Higo
    • Journal Title

      Dysphasia in rare conditions. An Encyclopedia(Plural Pub. San Diego, USA)

      Pages: 385-392

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Leiomyosarcoma of the hypopharynx : A case report.2008

    • Author(s)
      Takahashi T, Higo R, Nakata H, Sugasawa M
    • Journal Title

      Auris Nasus Larynx. 35

      Pages: 304-307

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leiomyosarcoma of the hypopharynx: A case report.2008

    • Author(s)
      Takahashi T, Higo R, Nakata H, Sugasawa M
    • Journal Title

      Auris Nasus Larynx 35

      Pages: 304-307

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Salivary duct carcinoma in the sinonasal tract2007

    • Author(s)
      Higo R Takahashi T, Nakata H, Harada H, Sugasawa M.
    • Journal Title

      Eur Arch Otorhinolaryngol 264

      Pages: 561-563

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 当院における下咽頭癌症例の検討2011

    • Author(s)
      肥後隆三郎、工藤睦夫、内田淳、清水俊行、大氣誠道、洲崎春海
    • Organizer
      第21回日本頭頸部外科学会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Final Research Report
  • [Presentation] 舌可動部全摘後、皮弁壊死を生じた舌癌患者の嚥下機能について2010

    • Author(s)
      肥後隆三郎、洲崎春海、高城文彦, 他
    • Organizer
      第62回日本耳鼻咽喉科学会総会
    • Place of Presentation
      大分
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経・筋疾患における摂食・嚥下障害2010

    • Author(s)
      肥後隆三郎
    • Organizer
      第23回日本口腔・咽頭科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Manometric assessment of pharyngeal swallowing pressure after mandibular reconstruction2010

    • Author(s)
      Ryuzaburo Higo, Harumi Suzaki
    • Organizer
      a Japan Joint meeting of Otorhinolaryngology-Head & Neck
    • Place of Presentation
      Seoul
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下咽頭部分切除症例における嚥下圧測定による嚥下機能の検討2010

    • Author(s)
      肥後隆三郎、洲崎春海、高城文彦, 他
    • Organizer
      第111回日本耳鼻咽喉科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下咽頭部分切除症例における嚥下圧測定による嚥下機能の検討2010

    • Author(s)
      肥後隆三郎、洲崎春海、高城文彦、盛田恵、松村聡子、中平光彦、菅澤正
    • Organizer
      第111回日本日本耳鼻咽喉科学会
    • Place of Presentation
      仙台
    • Related Report
      2010 Final Research Report
  • [Presentation] 舌可動部全摘後、皮弁壊死を生じた舌癌患者の嚥下機能について2010

    • Author(s)
      肥後隆三郎、洲崎春海、高城文彦、盛田恵、松村聡子、中平光彦、菅澤正
    • Organizer
      第62回日本本気管食道科学会総会
    • Place of Presentation
      大分
    • Related Report
      2010 Final Research Report
  • [Presentation] Manometric assessment of pharyngeal swallowing pressure after mandibular reconstruction2010

    • Author(s)
      Ryuzaburo Higo, Harumi Suzaki, Mitsuhiko Nakahira, Masashi Sugasawa
    • Organizer
      13^<th> Korea Japan Joint meeting of Otorhinolaryngology-Head & Neck surgery.
    • Place of Presentation
      Seoul
    • Related Report
      2010 Final Research Report
  • [Presentation] 臨床セミナー「口腔咽頭疾患と嚥下機能」神経・筋疾患における摂食・嚥下障害2010

    • Author(s)
      肥後隆三郎
    • Organizer
      第23回日本口腔・咽頭科学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 中咽頭癌再建症例における嚥下圧測定による嚥下機能の検討2010

    • Author(s)
      肥後隆三郎、高城文彦、盛田恵、松村聡子、中平光彦、菅澤正
    • Organizer
      第20回日本頭頸部外科学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] EVALUATING POSTSURGICAL SWALLOWING DISTURBANCE AND FUNCTION IN PATIENTS WITH OROPHARYNGEAL CANCER2009

    • Author(s)
      肥後隆三郎
    • Organizer
      Taiwan an Japan Otolaryngology Head & Neck conference
    • Place of Presentation
      Taiwan
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔・中咽頭癌再建症例における嚥下圧測定による嚥下機能の検討2009

    • Author(s)
      肥後隆三郎、高城文彦、盛田恵、松村聡子、中平光彦、菅澤正
    • Organizer
      第61回日本本気管食道科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] EVALUATING POSTSURGICAL SWALLOWING DISTURBANCE AND FUNCTION IN PATIENTS WITH OROPHARYNGEAL CANCER2009

    • Author(s)
      Ryuzaburo Higo, Harumi Suzaki, Mitsuhiko Nakahira, Masashi Sugasawa
    • Organizer
      10^<th> Taiwan an Japan Otolaryngology Head & Neck conference.
    • Place of Presentation
      Taiwan
    • Related Report
      2010 Final Research Report
  • [Presentation] Taiwan EVALUATING POSTSURGICAL SWALLOWING DISTURBANCE AND FUNCTION IN PATIENTS WITH OROPHARYNGEAL CANCER.2009

    • Author(s)
      Ryuzaburo Higo, M.D., Ph.D Mitsuhiko Nakahira, M.D., Masashi Sugasawa, M.D., Ph.D
    • Organizer
      10th Taiwan an Japan Otolaryngology Head & Neck conference
    • Place of Presentation
      Department of Head and Neck Surgery
    • Related Report
      2009 Self-evaluation Report
  • [Book] Multiple system atrophy (MSA)(Jones HN, Rosenbek JC (eds))(Dysphasia in rare conditions. An Encyclopedia.)2009

    • Author(s)
      肥後隆三郎
    • Publisher
      Plural Pub.San Diego, USA
    • Related Report
      2010 Final Research Report
  • [Book] 多系統萎縮症(MSA)による嚥下障害で栄養管理と気道確保を目標とした症例(摂食・嚥下リハビリテーション:50症例から学ぶ実践的アプローチ)2008

    • Author(s)
      肥後隆三郎
    • Publisher
      医師薬出版株式会社
    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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