Analysis of a role antigen-presenting cells play in the development of allergic conjunctival diseases

• Project/Area Number: 19592025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kochi University
• Principal Investigator: FUKUSHIMA Atsuki Kochi University, 教育研究部医療学系, 教授 (40281737)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: アレルギー性結膜炎 / マウス / 好酸球 / T細胞 / 抗原提示細胞 / マクロファージ共刺激分子 / CD11b / F4 / 80 / マクロファージ / 抗原提示細 / 樹状細胞 / 共刺激分子

Research Abstract

実験的アレルギー性結膜疾患発症における抗原提示細胞の役割を解析した. 結膜に存在する抗原提示細胞の表面に発現している共刺激分子が結膜炎誘導能を持つT細胞を活性化し, 結膜炎発症に関与している可能性が示唆された. 抗原提示細胞としての機能を持つマクロファージにはF4/80やCD11bが発現している. これらの分子はマクロファージのみならず好酸球にも発現しており, 結膜好酸球浸潤に重要な働きを持つことが判った.

Research Products

• [Journal Article] Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis (2009)
  • Author(s): Sumi T, Ishida W, Mittler RS, Yagita H, Taguchi O, Fukushima A.
  • Journal Title: Int Arch Allergy Immunol. 148 Pages: 305-310
  • Peer Reviewed
• [Journal Article] Activation of tumor necrosis factor-related apoptosis-inducing ligand receptor enhances the severity of murine allergic conjunctivitis (2009)
  • Author(s): Sumi T, Ishida W, Okumura K, Yagita H, Fukushima A.
  • Journal Title: Br J Ophthalmol 93 Pages: 110-115
  • Peer Reviewed
• [Journal Article] Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice. (2009)
  • Author(s): Sumi T, Fukushima A, Nishino K, Fukuda K, Kumagai N, Nishida T, Ueno H.
  • Journal Title: Cell Biol Int. 33 Pages: 534-541
  • Peer Reviewed
• [Journal Article] Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis. (2008)
  • Author(s): Fukushima A, Sumi T, Ishida W, Yamada J, Iwakura Y, Ueno H.
  • Journal Title: Int Arch Allergy Immunol. 147 Pages: 206-212
  • Peer Reviewed
• [Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice (2008)
  • Author(s): Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, Akiba H, Yagita H, Ueno H.
  • Journal Title: International Archive Allergy and Immunology 146 Pages: 36-43
  • Peer Reviewed
• [Journal Article] Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis (2008)
  • Author(s): Fukushima A, Sumi T, Ishida W, Ojima A, Kajisako M, Koyanagi A, Koyama N, Yagita H.
  • Journal Title: Immunol Letters 121 Pages: 140-147
  • Peer Reviewed
• [Journal Article] CD27 and CD70 do not play a critical role in the development of experimental allergic conjunctivitis in mice (2008)
  • Author(s): Sumi T, Ishida W, Ojima A, Kajisako M, Sakanishi T, Yagita H, Fukushima A.
  • Journal Title: Immunol Letters. 119 Pages: 91-96
  • Peer Reviewed
• [Journal Article] The Effect of a Combined Therapy with a Histamine H(1) Antagonist and a Chemical Mediator Release Inhibitor on Allergic Conjunctivitis. (2008)
  • Author(s): Fujishima H, Fukagawa K, Tanaka M, Uchio E, Takamura E, Nakagawa Y, Miyazaki D, Fukushima A, Okamoto S, Yokoi N.
  • Journal Title: Ophthalmologica 222 Pages: 232-239
  • Peer Reviewed
• [Journal Article] Depletion of thymus-derived CD4+CD25+ T cells abrogates the suppressive effects of α-galactosylceramide treatment on experimental allergic conjunctivitis (2008)
  • Author(s): Fukushima A, Sumi T, Ishida W, Ojima A, Kajisako M, Ueno H, Taguchi O.
  • Journal Title: Allergol Int. 57 Pages: 241-246
  • NAID: 10024419867
  • Peer Reviewed
• [Journal Article] Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice. (2008)
  • Author(s): Fukushima A, et al
  • Journal Title: International Archive Allergy and Immunology 146 Pages: 36-43
  • Peer Reviewed
• [Journal Article] Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis. (2008)
  • Author(s): Fukushima A, et al
  • Journal Title: International Archive Allergy and Immunology 147 Pages: 206-212
  • Peer Reviewed
• [Journal Article] Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis. (2008)
  • Author(s): Fukushima A, et al
  • Journal Title: Immunol Letters 121 Pages: 140-147
  • Peer Reviewed
• [Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice (2007)
  • Author(s): Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yamazaki T, Akiba H, Okumura K, Yagita H, Ueno H.
  • Journal Title: Immunol Letters 113 Pages: 52-57
  • Peer Reviewed
• [Journal Article] Cryptomeria japonica-induced allergic conjunctivitis in mice (2007)
  • Author(s): Fukushima A, Shii D, Sumi T, Kageyama T,Ueno H.
  • Journal Title: Biol Pharm Bull 30 Pages: 1745-1747
  • NAID: 110006380261
  • Peer Reviewed
• [Journal Article] T-cell Ig and mucin domain-containing protein (Tim)-2 regulates murine allergic conjunctivitis during the effector phase (2007)
  • Author(s): Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, Akiba H, Yagita H, Ueno H.
  • Journal Title: Immunol Letters 110 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Endogenous IL-10 produced by antigen-irrelevant cells promotes the development of experimental murine allergic conjunctivitis (2007)
  • Author(s): Fukushima A, Sumi T, Fukuda K, kumagai N, Nishida T, Ueno H
  • Journal Title: Int Arch Allergy Immunol 144 Pages: 79-84
  • Peer Reviewed
• [Journal Article] Roles of CD4+CD25+T cells in the development of experimental murine allergic conjunctivitis (2007)
  • Author(s): Fukushima A, Yamaguchi T, Sumi T, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 245 Pages: 705-714
  • Peer Reviewed
• [Journal Article] Thymus-derived CD4+CD25+T cells suppress the development of murine allergic conjunctivitis (2007)
  • Author(s): Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
  • Journal Title: Arch Allergy Immunol 143 Pages: 276-281
  • Peer Reviewed
• [Journal Article] Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and-3 suppress the induction and progression of murie allergic conjunctivitis (2007)
  • Author(s): Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Akiba H, Okumura K, Yagita H, Ueno H.
  • Journal Title: Biochem Biophys Res Commun 353 Pages: 211-216
  • Peer Reviewed
• [Journal Article] Differential contributions of B7-1 and B7-2 to the development or murine experimental allergic conjunctivitis (2007)
  • Author(s): Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H.
  • Journal Title: Immunol Lett 108 Pages: 62-67
  • Peer Reviewed
• [Journal Article] Therapeutic effects and mechanisms of action of cyclosporine A ophthalmic solution in the treatment of vernal keratoconjunctivitis. (2007)
  • Author(s): Shii D, Fukushima A.
  • Journal Title: Curr Pharmaceutical Analysis 3 Pages: 213-220
  • Peer Reviewed
• [Journal Article] Roles of T cells in the development of allergic conjunctival diseases (2007)
  • Author(s): Fukushima A.
  • Journal Title: Cornea 26
  • Peer Reviewed
• [Journal Article] Cryptomeria japonica-induced allergic conjunctivitis in mice (2007)
  • Author(s): Fukushima A, Shii D, Sumi T, Kageyama T, Ueno H
  • Journal Title: Biol Pharm Bull 30 Pages: 1745-1747
  • NAID: 110006380261
  • Peer Reviewed
• [Journal Article] B7-H3 regulates the development of experimental allergic conjunctiviti s in mice (2007)
  • Author(s): Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yamazaki T, Akiba H, Okumura K, Yagita H, Ueno H.
  • Journal Title: Immunol Letters 113 Pages: 52-57
  • Peer Reviewed
• [Book] 新眼科薬物療法のコツと落とし穴 : 春季カタルにおける免疫抑制剤点眼の使い方 (2008)
  • Author(s): 福島敦樹
  • Total Pages: 2
  • Publisher: 中山書店