Functional analysis of costimulatory molecules in autoimmune uveitis and their intervention for clinical application
Project/Area Number |
19592040
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Juntendo University |
Principal Investigator |
AKIBA Hisaya Juntendo University, 医学部, 准教授 (60338316)
|
Co-Investigator(Kenkyū-buntansha) |
USUI Yoshihiko 東京医科大学, 医学部, 助教 (50408142)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | T細胞分化・制御 / 補助シグナル分子 / 自己免疫疾患 / 喘息 / アレルギー / 実験的自己免疫性ぶどう膜網膜炎 / EAU / OX40-OX40L |
Research Abstract |
補助シグナル分子は、T細胞の活性化や機能に重要な役割を担っており、これらの働きを制御する抗体を開発することにより、難治性ぶどう膜網膜炎の治療が可能になるのではないかと考え、種々の補助シグナル分子に対する抗体を作製し、ぶどう膜網膜炎マウスモデルに投与して治癒効果の検討を行った。この内、T細胞分化に関わる補助シグナル分子OX40Lに対する抗体投与が、発症抑制に効果的であり、臨床応用に期待がもてる結果が得られた。
|
Report
(3 results)
Research Products
(46 results)
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[Journal Article] Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice2009
Author(s)
Usui, Y., M. Takeuchi, T. Hattori, Y. Okunuki, K. Nagasawa, T. Kezuka, K. Okumura, H. Yagita, H. Akiba, and H. Goto.
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Journal Title
Arch Ophthalmol 127
Pages: 514-519
Related Report
Peer Reviewed
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[Journal Article] RANK-RANKL signaling pathway is critically involved in the function of CD4+ CD25+ regulatory T cells in chronic colitis2009
Author(s)
Totsuka, T., T. Kanai, Y. Nemoto, T. Tomita, R. Okamoto, K. Tsuchiya, T. Nakamura, N. Sakamoto, H. Akiba, K. Okumura, H. Yagita, and M. Watanabe.
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Journal Title
J Immunol 182
Pages: 6079-6087
Related Report
Peer Reviewed
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[Journal Article] Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis2008
Author(s)
Wong, M. G., Y. Suzuki, C. Tanifuji, H. Akiba, K. Okumura, T. Sugaya, T. Yamamoto, S. Horikoshi, S. Y. Tan, C. Pollock, and Y. Tomino.
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Journal Title
J Am Soc Nephrol 19
Pages: 290-297
Related Report
Peer Reviewed
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[Journal Article] The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model2008
Author(s)
Ueno, T., A. Habicht, M. R. Clarkson, M. J. Albin, K. Yamaura, O. Boenisch, J. Popoola, Y. Wang, H. Yagita, H. Akiba, M. J. Ansari, J. Yang, L. A. Turka, D. M. Rothstein, R. F. Padera, N. Najafian, and M. H. Sayegh
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Journal Title
J Clin Invest 118
Pages: 742-751
Related Report
Peer Reviewed
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[Journal Article] Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function2007
Author(s)
Xiao, S., N. Najafian, J. Reddy, M. Albin, C. Zhu, E. Jensen, J. Imitola, T. Korn, A. C. Anderson, Z. Zhang, C. Gutierrez, T. Moll, R. A. Sobel, D. T. Umetsu, H. Yagita, H. Akiba, T. Strom, M. H. Sayegh, R. H. DeKruyff, S. J. Khoury, and V. K. Kuchroo
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Journal Title
J Exp Med 204
Pages: 1691-1702
Related Report
Peer Reviewed
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[Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival2007
Author(s)
Hattori, T., Y. Usui, Y. Okunuki, Y. Sonoda, M. Usui, E. Takada, J. Mizuguchi, H. Yagita, K. Okumura, H. Akiba, and M. Takeuchi
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Journal Title
Eur J Immunol 37
Pages: 3597-3604
Related Report
Peer Reviewed
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[Journal Article] B7-H3 regulates the development of experimental allergic conjunctivitis in mice2007
Author(s)
Fukushima, A., T. Sumi, K. Fukuda, N. Kumagai, T. Nishida, T. Yamazaki, H. Akiba, K. Okumura, H. Yagita, and H. Ueno
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Journal Title
Immunol Lett 113
Pages: 52-57
Related Report
Peer Reviewed
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