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Tissue engineering a model for the human ear : Assessment of the mechanical property

Research Project

Project/Area Number 19592082
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionKinki University

Principal Investigator

ISOGAI Noritaka  Kinki University, 医学部, 教授 (90203067)

Co-Investigator(Kenkyū-buntansha) ENJO Mitsuhiro  近畿大学, 医学部, 講師 (30441009)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords耳介軟骨 / 再生医学 / メカニカルテスト / 生分解性ポリマー / 折り曲げ応力 / 生分解性ポリマ
Research Abstract

複雑な三次元形状を有する再生耳介形状軟骨に対して、生理的な変形を加えた場合の再生軟骨の折り曲げ応力を検討した。実験群は、耳介軟骨細胞、肩関節軟骨細胞、鼻中隔細胞、肋軟骨細胞に由来する再生軟骨群の4部位から採取した軟骨細胞を使用して、耳介形状軟骨の再生を行った4群を設定した。再生軟骨は、臨床使用に長期間耐えうる力学的特性を持つことが必要と考えられ、今後、さらに詳細な力学的機能評価(破壊強度や疲労強度)が必要と考えている。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] Tissue engineering a model for the human ear : Assessment of size, shape, morphology, and gene expression following seeding of different chondrocytes2009

    • Author(s)
      Isogai N, 他7名, Enjo M, 他7名
    • Journal Title

      Would Repair and Regenerations 17巻

      Pages: 136-146

    • NAID

      10031181542

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue engineering a model for the human ear : Assessment of size, shape, morphology, and gene expression following seeding of different chondrocytes2009

    • Author(s)
      Kusuhara H
    • Journal Title

      Wound Repair and Regeneration 17

      Pages: 136-146

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tissue engineering a human ear model following seeding of different chondrocytes2008

    • Author(s)
      Isogai N
    • Organizer
      The TERMIS-NA 2008
    • Place of Presentation
      米国
    • Year and Date
      2008-12-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Tissue engineering a human ear model following seeding of different chondrocytes2008

    • Author(s)
      Isogai N
    • Organizer
      The TERMIS-NA 2008
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] 自家移植モデルにおける新生軟骨の再生誘導2008

    • Author(s)
      磯貝典孝
    • Organizer
      再生医療材料研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ヒト耳介形状軟骨の再生誘導におけるPGA-P(LA-CL)ポリマーの有用性2008

    • Author(s)
      森廣政
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 新たな骨誘導型生分解ポリマーを用いた指骨の再生誘導2008

    • Author(s)
      和田仁孝
    • Organizer
      第50回日本手の外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-04-19
    • Related Report
      2008 Final Research Report
  • [Presentation] Bone and cartilage tissue engineering form basic research to clinical application2008

    • Author(s)
      Isogai N
    • Organizer
      The Korean Wound Care Society 2008
    • Place of Presentation
      韓国
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨・軟骨組織の再生誘導と再建外科への展開2008

    • Author(s)
      磯貝典孝
    • Organizer
      第26回大阪マイクロサージャリー研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-02
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Advances in tissue engineering models of human phalanx and ears2008

    • Author(s)
      Isogai N
    • Organizer
      International Conference on Advances in Bioresorbable Biomaterials for Tissue Engineering
    • Place of Presentation
      シンガポール
    • Year and Date
      2008-01-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨・軟骨組織の再生誘導と再建外科への展開2007

    • Author(s)
      磯貝典孝
    • Organizer
      第34回日本マイクロサージャリー学会ランチョンセミナー
    • Place of Presentation
      福島
    • Year and Date
      2007-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 軟骨再生におけるPGA含入P(LA-CL)ポリマーの有用性2007

    • Author(s)
      森廣政
    • Organizer
      第16回日本形成外科学会基礎学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 培養ヒト鼻中隔軟骨細胞を用いたヒト耳介形状軟骨の再生誘導2007

    • Author(s)
      松永吉真
    • Organizer
      第16回日本形成外科学会基礎学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨・軟骨組織における再生誘導と形成外科領域への応用2007

    • Author(s)
      磯貝典孝
    • Organizer
      第41回京都形成外科医会
    • Place of Presentation
      京都
    • Year and Date
      2007-06-02
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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