Evaluation of risk factors and early diagnosis of sepsis.
| Project/Area Number |
19592089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MAYUMI Toshihiko Nagoya University, 医学部附属病院, 講師 (90281071)
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| Co-Investigator(Kenkyū-buntansha) |
ARISHIMA Takuro 富山大学, 医学部, 准教授 (20335045)
遠藤 重厚 岩手医科大学, 医学部, 教授 (30160394)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 敗血症 / リスク因子 / 遺伝子多型 / 診断 / エンドトキシン / antithrombin活性 / disseminated intravascular coagulation (DIC) / 早期診断 / recombinant thrombomodulin / 敗血症性ショック / 遺伝子技術 / サーベイランス / 予後 |
|---|
| Research Abstract |
Since even now, sepsis is still high mortality, control of sepsis is an important strategy. In this study, we elucidated the prognostic predictor of sepsis, severe sepsis, and septic shock. We started multicenter study to analyze the genetic polymorphism of the patients of septic patients in the ICU and their relations to the prognosis.
Also, we antithrombin (AT) activity after AT administration and the rate of increase of the AT activity value after the AT administration were significantly higher in survived septic DIC patients than those fatal patients. Therefore, it was suggested that the prognostic value by AT activity and its change before and after AT administration.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Expert consensus for the treatment of disseminated intravascular coagulation in Japan.2010
Author(s)
Wada H, Asakura H, Okamoto K, Iba T, Uchiyama T, Kawasugi K, Koga S, Mayumi T, Koike K, Gando S, Kushimoto S, Seki Y, Madoiwa S, Maruyama I, Yoshioka A
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Journal Title
Thromb Res(Japanese Society of Thrombosis Hemostasis/DIC subcommittee.) 125
Pages: 6-11
Related Report
Peer Reviewed
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[Journal Article] Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DJapanese Association for Ac2009
Author(s)
Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Ikeda T, Ishikura H, Iba T, Ueyama M, Eguchi Y, Otomo Y, Okamoto K, Kushimoto S, Endo S, Shimazaki S
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Journal Title
Thrombosis Research 123
Pages: 715-718
Related Report
Peer Reviewed
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[Presentation] 日本救急医学会DIC特別委員会. SIRS-associated coagulopathy(SAC)病態と転帰予測因子.2007
Author(s)
小倉裕司、小関一英, 大友康裕, 齋藤大蔵, 岡本好司, 真弓俊彦, 射場敏明, 江口豊, 池田寿昭, 石倉宏泰, 上山昌史, 久志本成樹, 遠藤重厚, 島崎修次, 丸藤哲
Organizer
第30回日本血栓止血学会学術集会
Place of Presentation
三重県志摩
Year and Date
2007-11-16
Related Report
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