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Therapeutic efficacy of immunoglobulin on the multiple organ injury associated with severe sepsis

Research Project

Project/Area Number 19592094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionNagoya City University

Principal Investigator

HARADA Naoaki  Nagoya City University, 大学院・医学研究科, 准教授 (00309915)

Co-Investigator(Kenkyū-buntansha) OKAJIMA Kenji  名古屋市立大学, 大学院・医学研究科, 教授 (60152295)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords免疫グロブリン / 虚血再灌流障害 / インスリン様成長因子-I / 知覚神経 / アポトーシス / 腎障害 / 脊髄後根神経節細胞 / カルシトニン遺伝子関連ペプチド / インスリン様成長因子-1 / 賢障害
Research Abstract

本研究では、人免疫グロブリン製剤(Ig)の新しい臓器保護作用を解析するためにIgがカプサイシン感受性知覚神経の活性化を促進して、虚血再灌流性臓器障害を軽減するか否かを解析した。Ig は知覚神経を刺激して、臓器保護作用に重要なインスリン様成長因子-I(IGF-I)の生成を促し、マウスの虚血再灌流性腎障害を軽減することが判明した。よって、Igは重症敗血症などによる臓器障害抑制を目的とした治療にも有用である可能性が示された

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2008 2007 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (3 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Promotion of insulin-like growth factor-I production by sensory neuron stimulation2008

    • Author(s)
      岡嶋研二、原田直明
    • Journal Title

      molecular mechanism(s) and therapeutic implications、Current Medicinal Chemistry 15

      Pages: 3095-3112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats2008

    • Author(s)
      原田直明、岡嶋研二
    • Journal Title

      Growth Hormone & IGF Research 18

      Pages: 75-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats2008

    • Author(s)
      原田直明、岡嶋研二、礒部博隆
    • Journal Title

      Shock30

      Pages: 379-387

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice2008

    • Author(s)
      原田直明、岡嶋研二、栗原裕基、中潟直巳
    • Journal Title

      Critical Care Medicine 36

      Pages: 971-974

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antithrombin inhibits LPS-induced TNF production by monocytes in vitro through inhibition of Egr-1 expression2008

    • Author(s)
      幸村英文、内場光浩、水落雄一朗、新井正徳、原田直明、勝屋弘忠、岡嶋研二
    • Journal Title

      Journal of Thrombosis and Haemostasis 6

      Pages: 499-507

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans2008

    • Author(s)
      原田直明、岡嶋研二、栗原裕基、中潟直巳
    • Journal Title

      Growth Hormone & IGF Research 18

      Pages: 335-344

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Promotion of insulin-like growth factor-I production by sensory neuron stimulation ; molecular mechanism (s) and therapeutic implications2008

    • Author(s)
      岡嶋研二, 原田直明
    • Journal Title

      Current Medicinal Chemistry 15

      Pages: 3095-3112

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.2008

    • Author(s)
      原田直明, 岡嶋研二
    • Journal Title

      Growth Hormone & IGF Research 18

      Pages: 75-81

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats2008

    • Author(s)
      原田直明, 岡嶋研二, 礒部博隆
    • Journal Title

      Shock 30

      Pages: 379-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice.2008

    • Author(s)
      原田直明, 岡嶋研二, 栗原裕基, 中潟直巳
    • Journal Title

      Critical Care Medicine 36

      Pages: 971-974

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antithrombin inhibits LPS-induced TNF production by monocytes in vitro through inhibition of Egr-1 expression.2008

    • Author(s)
      幸村英文, 内場光浩, 水落雄一朗, 新井正徳, 原田直明, 勝屋弘忠, 岡嶋研二
    • Journal Title

      Journal of Thrombosis and Haemostasis 6

      Pages: 499-507

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans.2008

    • Author(s)
      原田直明, 岡嶋研二, 栗原裕基, 中潟直巳
    • Journal Title

      Growth Hormone & 1GF Research 18

      Pages: 335-344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of sensory neurons by capsaicin increase tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice2007

    • Author(s)
      原田直明
    • Journal Title

      Neuropharmacology 52

      Pages: 1303-1311

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses2007

    • Author(s)
      原田直明
    • Journal Title

      Thrombosis and Haemostasis 97

      Pages: 81-87

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats2007

    • Author(s)
      原田直明
    • Journal Title

      Growth Horm IGF Res 18

      Pages: 75-81

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stimulation of sensory neurons by capsaicin increase tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice.2007

    • Author(s)
      Harada N
    • Journal Title

      Neuropharmacology 52

      Pages: 1303-1311

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Danaparoid sodium reduces ischemia/reperfusion-induced liver injury in rats by attenuating inflammatory responses2007

    • Author(s)
      Harada N
    • Journal Title

      Thrombosis and Haemostasis 97

      Pages: 81-87

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.2007

    • Author(s)
      Harada N
    • Journal Title

      Growth Horm IGF Res 18

      Pages: 75-81

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Anti-inflammatory activity of immunoglobulins : involvement of interaction of FcgRI on sensory neurons2008

    • Author(s)
      原田直明, 岡嶋研二
    • Organizer
      6th International Congress on Autoimmunity
    • Place of Presentation
      Porto, Portugal
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intravenous immunoglobulin reduces the ischemia/reperfusion-induced renal injury by increasing insulin-like growth factor-I production in mice2008

    • Author(s)
      原田直明、岡嶋研二
    • Organizer
      28nd International Symposium on Intensive Care and Emergency Medicine
    • Place of Presentation
      Brussels, Belgium
    • Year and Date
      2008-03-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Intravenous immunoglobulin reduces the ischemia/reperfusion-induced renal injury by increasing insulin-like growth factor-I production in mice2008

    • Author(s)
      Harada N
    • Organizer
      28th International Symposium on Intensive Care and Emergency Medicine
    • Place of Presentation
      ベルギー国、ブリュッセル市
    • Year and Date
      2008-03-18
    • Related Report
      2007 Annual Research Report
  • [Book] Tanaka K, Davie EW (eds) Recent Advances in Thrombosis and Hemostasis2008

    • Author(s)
      原田直明、岡嶋研二
    • Publisher
      Springer Japan (Tokyo)、New aspects of anti-inflammatory activities of antithrombin-Molecular mechanism(s) and therapeutic implications-. In
    • Related Report
      2008 Final Research Report
  • [Book] New aspects of anti-inflammatory activities of antithrombin-Molecular mechanism (s) and therapeutic implications-. In : Tanaka K, Davie EW (eds) Recent Advances in Thrombosis and Hemostasis.2008

    • Author(s)
      原田直明, 岡嶋研二
    • Total Pages
      13
    • Publisher
      Springer Japan (Tokyo)
    • Related Report
      2008 Annual Research Report
  • [Book] Xa阻害薬のすべて2007

    • Author(s)
      原田直明
    • Publisher
      先端医学社
    • Related Report
      2008 Final Research Report
  • [Book] Xa阻害薬のすべて2007

    • Author(s)
      原田直明
    • Publisher
      Xa阻害薬の炎症制御による臓器障害抑制を探る
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-cu.ac.jp/molbio.dir/

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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