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Study of a novel protein secretion system of Porphyromonas gingivalis

Research Project

Project/Area Number 19592135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

SAIKI Keitarou  The Nippon Dental University, 生命歯学部, 講師 (30297973)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords口腔細菌学 / 蛋白分泌 / ジンジパイン / 歯周病
Research Abstract

A novel outer membrane protein Sov and a novel membrane protein PG27 were identified as essential factors for the secretion of gingipain protease virulence factors of Porphyromonas gingivalis. The C-terminal portion of Sov is exposed to the extracellular milieu and involved in the modulation of Sov function. These results suggest that gingipains are secreted via a novel protein secretion pathway, and that Sov and PG27 are promising targets for antiperiodontitis drug development.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results)

  • [Journal Article] The role of Sov protein in the secretion of gingipain protease virulence factors of Porphyromonas gingivalis.2010

    • Author(s)
      Keitarou Saiki, Kiyoshi Konishi
    • Journal Title

      FEMS Micobiol Lett 302

      Pages: 166-174

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of Sov protein in the secretion of gingipain protease virulence factors of Porphyromonas gingivalis.2010

    • Author(s)
      Keitarou Saiki
    • Journal Title

      FEMS Microbiol.Lett. 302

      Pages: 166-174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system.2009

    • Author(s)
      Ikumi Ishiguro, Keitarou Saiki, Kiyoshi Konishi
    • Journal Title

      FEMS Microbiol Lett 292

      Pages: 261-267

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system.2009

    • Author(s)
      Ikumi Ishiguro
    • Journal Title

      FEMS Microbiol. Lett. 292

      Pages: 261-267

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯周病原因菌の病原因子分泌におけるSov蛋白の役割2010

    • Author(s)
      才木桂太郎, 古西清司
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 細菌の新規蛋白質分泌系に関わる新規外膜蛋白質Sovの解析2009

    • Author(s)
      才木桂太郎, 古西清司
    • Organizer
      第82回日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 新規の蛋白質分泌系に関わる巨大蛋白Sovの機能必須領域の検索2009

    • Author(s)
      才木桂太郎, 古西清司
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 細菌の新規蛋白質分泌系に関わる新規外膜蛋白質Sovの解析2009

    • Author(s)
      才木桂太郎
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Porphyromonas gingivalisの新規蛋白分泌系に関与する蛋白質PG27の同定2009

    • Author(s)
      石黒生美, 才木桂太郎, 古西清司
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-21
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 新規の蛋白質分泌系に関わる巨大蛋白Sovの機能必須領域の検索2009

    • Author(s)
      才木 桂太郎
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-03-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯周病原因菌で見つかった新規蛋白分泌系に関わる巨大蛋白Sovの同定2008

    • Author(s)
      才木桂太郎, 古西清司
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯周病原因菌で見つかった新規蛋白分泌装系に関わる巨大蛋白Sovの同定2008

    • Author(s)
      才木桂太郎
    • Organizer
      第81回日本細菌学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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