The application of functional elucidation in epithelial-mesenchymal interaction to the practical treatment in chronic periodontitis
| Project/Area Number |
19592167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SHIMONISHI Mitsuru Tohoku University, 病院, 助教 (40302153)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 免疫 / 感染 / 炎症 / マラッセの上皮遺残 / MMP-2 / 細胞間相互作用 / 免疫・感染・炎症 |
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| Research Abstract |
The tissues were sampled from the root of human extracted teeth and produced outgrowths containing both epithelial cells and fibroblasts from human periodontal ligaments (HPDL). Type IV collagen were found at the interface between cells of the epithelial rests of Malassez (ERM cells) and HPDL fibroblasts. MMP-2 can degrade type IV collagen. The current study was undertaken to examine the expression of MMP-2 at the interface. These findings indicate that the ERM cells stimulate the production of MMP-2 in HPDL fibroblasts. Up-regulated MMP-2 activated by MMP-14 in ERM cells could degrade matrix molecules, such as Type IV collagen in the basal membrane between ERM cells and HPDL fibroblasts. We believe that these results are applied to the practical treatment in chronic periodontitis.
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Report
(4 results)
Research Products
(16 results)
