| Project/Area Number |
19592170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Okayama University |
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Principal Investigator |
ASAUMI Junichi Okayama University, 大学院・医歯薬学総合研究科, 教授 (60184131)
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| Co-Investigator(Kenkyū-buntansha) |
KONOUCHI Hironobu 岡山大学, 岡山大学病院, 講師 (20294423)
YANAGI Yoshinobu 岡山大学, 岡山大学病院, 助教 (50284071)
HISATOMI Miki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60314704)
MATSUZAKI Hidenobu 岡山大学, 医学部・歯学部附属病院, 助教 (70325124)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ダイナミックMRI / 口腔扁平上皮癌 / contrast index / PCNA / microvessel density / 腫瘍血管新生 / 腫瘍増殖能 / Contrast Index / MIB-1(Ki-67) / CD44 / CD133 / VEGF / Flk-1 / MRI / 唾液腺腫瘍 / 良性 / 悪性 |
|---|
| Research Abstract |
The histopathological prognostic factors, tumor proliferation and microvessel density (MVD) showed significant correlations with enhancement parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in oral squamous cell carcinoma (SCC). The assessment of DCE-MRI parameters may prove to be a valuable non-invasive method for assessing tumor cell proliferation and MVD of patients with oral cancer.
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