• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of effective conservative combined therapy for malignant tumor using quantitative analysis for vascular structure

Research Project

Project/Area Number 19592187
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKanagawa Dental College

Principal Investigator

SAKURAI Takashi  Kanagawa Dental College, 歯学部, 准教授 (60277910)

Co-Investigator(Kenkyū-buntansha) KAWAMATA Ryota  神奈川歯科大学, 歯学部, 助教 (40329199)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords放射線療法 / 温熱療法 / 化学療法 / 悪性腫瘍 / マウス / KB細胞 / ヌードマウス / KB腫瘍 / 放射線治療
Research Abstract

This study was conducted with two phases of cellular level and in vivo level using experimental animal, for the aim of development of effective conservative combined therapy for malignant tumor. Radiotherapy, chemotherapy and hyperthermia were chosen for the combined therapy, because those were commonly used clinically. The combined therapy that high treatment effect was obtained at a cellular level caused decrease and fragmentation of vascular around a tumor, and it showed high treatment effect for the malignant tumors of mice. Furthermore, it was suggested that we will be able to markedly decrease the prescription dose of each therapy.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2011 2010 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (16 results)

  • [Journal Article] Relationship between radiation dose reduction and image quality change in photostimulable phosphor luminescence X-ray imaging systems2010

    • Author(s)
      Takashi Sakurai
    • Journal Title

      Dentomaxillofacial Radiology

      Volume: 39 Pages: 207-215

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between radiation dose reduction and image quality change in photostimulable phosphor luminescence X-ray imaging systems2010

    • Author(s)
      Takashi Sakurai
    • Journal Title

      Dentomaxillofacial Radiology 39

      Pages: 207-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basic study on prescription of effective conservative combined therapy for malignant tumor using quantitative imaging analysis for vascular structure2009

    • Author(s)
      Takashi Sakurai、Ryota Kawamata、Isamu Kashima
    • Journal Title

      Program & proceedings、Yokosuka International Conference on Cancer icroenvironments 85

    • Related Report
      2010 Final Research Report
  • [Journal Article] Basic study on prescription of effective conservative combined therapy for malignant tumor using quantitative imaging analysis for vascular structure2009

    • Author(s)
      Takashi Sakurai, Ryota Kawamata, Isamu Kashima
    • Journal Title

      Program & proceedings, International Conference on Cancer Microenvironments 85

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Development of a quantitative analysis method for measuring the change in vascular structure of malignant tumors in small experimental animals2008

    • Author(s)
      Takashi Sakurai、Ryota Kawamata、Isamu Kashima
    • Journal Title

      Oral Radiology 24巻

      Pages: 1-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a quantitative analysis method for measuring the change in vascular structure of malignant tumors in small experimental animals2008

    • Author(s)
      Takashi Sakurai, Ryota Kawamata, Isamu Kashima
    • Journal Title

      Oral Radiology 24

      Pages: 1-9

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Development of a quantitative analysis method for measuring the change in vascular structure of malignant tumors in experimental animals.2008

    • Author(s)
      Takashi Sakurai
    • Journal Title

      Oral Radiology 24

      Pages: 1-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 悪性腫瘍に対する効果的併用療法に関する基礎的検討2011

    • Author(s)
      櫻井孝、川股亮太、香西雄介、鹿島勇
    • Organizer
      第42回横浜放射線治療懇話会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性腫瘍に対する効果的併用療法に関する基礎的検討2011

    • Author(s)
      櫻井孝
    • Organizer
      第42回横浜放射線治療懇話会
    • Place of Presentation
      崎陽軒本店(神奈川)
    • Year and Date
      2011-03-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性腫瘍に対する効果的な非観血的併用療法の処方に関する血管構造定量解析を用いた研究2010

    • Author(s)
      櫻井孝、川股亮太、香西雄介、若尾博美、鹿島勇
    • Organizer
      NPO法人日本歯科放射線学会第51回学術大会・第7回定例総会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-04-25
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] 悪性腫瘍に対する効果的な非観血的併用療法の処方に関する血管構造定量解析を用いた研究2010

    • Author(s)
      櫻井孝
    • Organizer
      NPO法人日本歯科放射線学会第51回学術大会
    • Place of Presentation
      鶴見大学記念館(神奈川)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] サプリメント「骨の友^[○!R]」が骨密度および骨質に与える影響に関する臨床的検討2010

    • Author(s)
      櫻井孝
    • Organizer
      NPO法人日本歯科放射線学会第51回学術大会
    • Place of Presentation
      鶴見大学記念館(神奈川)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] デジタルX線写真の読影2009

    • Author(s)
      櫻井孝
    • Organizer
      横須賀デンタルフェア
    • Place of Presentation
      横須賀口腔衛生センター(神奈川)
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Basic study on prescription of effective conservative combined therapy for malignant tumor using quantitative imaging analysis for vascular structure2009

    • Author(s)
      Takashi Sakurai、Ryota Kawamata、Isamu Kashima
    • Organizer
      Yokosuka International Conference on Cancer Microenvironments
    • Place of Presentation
      神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] Basic study on prescription of effective conservative combined therapy for malignant tumor using quantitative imaging analysis for vascular structure2009

    • Author(s)
      Takashi Sakurai, Ryota Kawamata, Isamu Kashima
    • Organizer
      International Conference on Cancer Microenvironments
    • Place of Presentation
      神奈川
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Basic study on prescription of effective conservative combined therapy for malignant tumor using quantitative imaging analysis for vascular structure2009

    • Author(s)
      Takashi Sakurai
    • Organizer
      International Conference on Cancer Microenvironments
    • Place of Presentation
      Shonan village center(Kanagawa)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 口腔機能を可能な限り温存できる口腔癌治療のために2008

    • Author(s)
      櫻井孝
    • Organizer
      市民公開講演会
    • Place of Presentation
      神奈川
    • Year and Date
      2008-10-26
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 口腔機能を可能な限り温存できる口腔癌治療のために2008

    • Author(s)
      櫻井 孝
    • Organizer
      市民公開講演会
    • Place of Presentation
      神奈川歯科大学
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 悪性腫瘍に対する効果的非観血的治療法に関する基礎的研究2008

    • Author(s)
      櫻井孝, 川股亮太, 若尾博美, 中村貢治, 香西雄介, 加来佑介, 斎藤勝, 鹿島勇
    • Organizer
      日本歯科放射線学会第207回関東地方会、第28回北日本地方会、第16回関東地方会
    • Place of Presentation
      福島
    • Year and Date
      2008-07-19
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 悪性腫瘍に対する効果的非観血的治療法に関する基礎的研究2008

    • Author(s)
      櫻井 孝
    • Organizer
      日本歯科放射線学会第207回関東地方会、第28回北日本地方会、第16回合同地方会
    • Place of Presentation
      郡山市民交流プラザ
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 実験小動物における悪性腫瘍血管構造に対する画像工学的定量解析法の開発2007

    • Author(s)
      櫻井 孝
    • Organizer
      第42回神奈川歯科大学学会総会
    • Place of Presentation
      神奈川歯科大学
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Quantitative imaging analysis method for vascular structure of malignant tumor in small experimental animals2007

    • Author(s)
      櫻井 孝
    • Organizer
      The 16th International Congress of Dentomaxillofacial Radiology
    • Place of Presentation
      Beijing Friendship Hotel, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] 悪性腫瘍周囲の血管構造解析法の開発2007

    • Author(s)
      川股 亮太
    • Organizer
      第48回日本歯科放射線学会総会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi