| Project/Area Number |
19592198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
UEDA Mio Osaka University, 歯学部附属病院, 医員 (90423136)
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| Co-Investigator(Kenkyū-buntansha) |
NOIRI Yuichiro 大阪大学, 歯学部附属病院, 講師 (50218286)
EBISU Shigeyuki 大阪大学, 大学院・歯学研究科, 教授 (50116000)
YOSHITAKE Fumio 大阪大学, 歯学部附属病院, 医員 (10452450)
ASAHI Yoko 大阪大学, 歯学部附属病院, 医員 (50456943)
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| Research Collaborator |
MAEZONO Hazuki 大阪大学, 大学院・歯学研究科
YAMAGUCHI Mikiyo 大阪大学, 歯学部附属病院, 医員 (30523089)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥6,017,300 (Direct Cost: ¥4,628,693、Indirect Cost: ¥1,388,607)
Fiscal Year 2009: ¥1,597,300 (Direct Cost: ¥1,228,693、Indirect Cost: ¥368,607)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 歯学 / 歯内療法学 / 細菌 / バイオフィルム / 歯周炎 / マクロライド / 抗生物質 / Porphyromonas gingivalis / 難治性根尖性歯周炎 / 抗菌薬 / クオラムセンシング / アジスロマイシン / Sub-MIC / オートインデューサー |
|---|
| Research Abstract |
The effect of azithromycin (AZM) and erythromycin (EM), which were macrolides, on Porphyromonas gingivalis biofilms produced by both static and flow-cell model was evaluated, and was compared with it against other antibiotics. AZM inhibited significantly both two biofilms in comparison with the other medicines at sub-minimum inhibitory concentration. It was guessed that the mechanism influenced three-dimensional structure or the signal transmission in the biofilm, but not was bactericidal namely an antibacterial action. And it was shown that its effect caused by the anti-biofilm action of AZM.
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