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Analysis of Wnt signal pathway in the invasion and metastasis of oral squamous carcinoma cells and application to molecule target therapy

Research Project

Project/Area Number 19592293
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

IWAI Soichi  Osaka University, 大学院・歯学研究科, 助教 (10362675)

Co-Investigator(Kenkyū-buntansha) YURA Yoshiaki  大阪大学, 大学院・歯学研究科, 教授 (00136277)
AOTA Keiko  大阪大学, 歯学部附属病院, 医員 (70437391)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsシグナル伝達 / 浸潤 / 遊走 / ウイントシグナル / 口腔扁平上皮癌
Research Abstract

beta-cateninの細胞質、核内集積によって、Wnt signalのcanonical経路が活性化され、浸潤能が上昇することが明らかとなった。さらにbeta-cateninの細胞内集積はRhoファミリーの活性化と細胞骨格の再構成により口腔扁平上皮癌細胞の遊走能を亢進させること、この現象にWnt/beta-catenin 経路の活性化が関与することが明確となった。さらにこの過程にWnt5aが関与することが示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 Other

All Journal Article (1 results) Presentation (11 results) Remarks (1 results)

  • [Journal Article] beta-cateninの細胞内集積が口腔扁平上皮癌細胞の生物学的特性に及ぼす影響2008

    • Author(s)
      孔智恵
    • Journal Title

      大阪大学歯学会雑誌 53巻1号

    • Related Report
      2008 Final Research Report
  • [Presentation] The involvment of Wnt-beta-catenin pathway in the migration of oral squamous carcinoma cells2008

    • Author(s)
      Atsuko Yonekawa, Soichi Iwai, Chie Kong, Gentaro Fujita, Masakazu Hamada, Mitsuhiro Nakazawa, Yoshiaki Yura
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-08
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞の遊走能におけるWnt/beta-catenin経路の関与2008

    • Author(s)
      米川 敦子
    • Organizer
      第45回日本口腔組織培養学会
    • Place of Presentation
      松本
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of Wnt beta-catenin pathway in the migration of oral squamous cell carcinoma cells2008

    • Author(s)
      米川敦子、岩井聡一、孔知恵、青田圭子、加藤逸郎、墨哲郎、中澤光博、由良義明
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] The role of Wnt beta-catenin pathway in the migration of oralsquamous cell carcinoma cells2008

    • Author(s)
      米川 敦子
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Wntシグナルが口腔扁平上皮癌細胞の遊走能に及ぼす影響2008

    • Author(s)
      米川 敦子
    • Organizer
      第53回日本口腔外科学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] The involvement of wnt beta-catenin signal pathway in the invasion and migration of oral squamous cell carcinoma cells2008

    • Author(s)
      Soichi Iwai, Atsuko Yonekawa, Chie Kong, Keiko Aota, Mitsuhiro Nakazawa, Yoshiaki Yura
    • Organizer
      EACR (European Association of Cancer Research) Congress Lyon
    • Place of Presentation
      France
    • Year and Date
      2008-07-07
    • Related Report
      2008 Final Research Report
  • [Presentation] The involvement of wnt beta-catenin signal pathway in the invasion and migration of oral squamous cell carcinoma cells.2008

    • Author(s)
      岩井 聡一
    • Organizer
      EACR (Europe Society of Cancer research)Congress
    • Place of Presentation
      Lyon France
    • Year and Date
      2008-07-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 口腔扁平上皮癌細胞の遊走能におけるWntシグナルの関与について2008

    • Author(s)
      米川敦子、岩井聡一、孔知恵、藤田源太郎、青田桂子、中澤光博、由良義明
    • Organizer
      第62回日本口腔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 口腔扁平上皮癌細胞の遊走能におけるWntシグナルの関与について2008

    • Author(s)
      米川 敦子
    • Organizer
      第62回日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effects of the accumulation of cytoplasmic beta-catenin on the migration and invasion in oral squamous cell carcinoma2007

    • Author(s)
      孔知恵、岩井聡一、米川敦子、加藤逸郎、中澤光博、由良義明
    • Organizer
      第66回日本癌学会
    • Year and Date
      2007-10-04
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of the accumulation of cytoplasnmic beta-catenin on the migration and invasion in oral squamous cen carcinoma2007

    • Author(s)
      岩井 聡一
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Remarks] 上記研究成果は本年3月に終了し、現在論文投稿中である。

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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