Newly Strategy by Anti-angiogenic Gene Therapy using Decoy System

• Project/Area Number: 19592342
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: KURAHARA Shin-ichi Kyushu University, 大学院・歯学研究院, 助教 (20304818)
• Co-Investigator(Kenkyū-buntansha): 石橋 浩晃 島根大学, 医学部, 准教授 (90254630) ; 鬼丸 満穂 九州大学, 医学研究院, 助教 (00380626) ; 竹之下 康治 九州大学, 歯学研究院, 准教授 (50117157)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔癌 / 血管新生 / 遺伝子治療 / 地管新生 / 分子標的治療

Research Abstract

Newly Strategy by Anti-angiogenic Gene Therapy using Decoy System

Research Products

• [Journal Article] Autocrine loop between vascular endothelial growth factor(VEGF)-C and VEGF Receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells. (2009)
  • Author(s): Matsuura M, Onimaru M, Yonemitsu Y, Suzuki H, Nakano T, Ishibashi H, Shirasuna K, Sueishi K.
  • Journal Title: Am J Pathology 175(4) Pages: 1709-21
• [Journal Article] Management of tongue squamous cell carcinoma in expectant patients: Report of two Cases. (2009)
  • Author(s): Kondo S, Ishibashi H, Nariai Y, Kato T, Enomoto Y, Karino M, Yoshino A, Sekine J
  • Journal Title: Asian J Oral Maxillofac Surg 21(2) Pages: 142-148
• [Journal Article] 1歳児の下顎骨に生じた小円形細胞腫瘍の1例 (2009)
  • Author(s): 蔵原慎一, 鬼丸満穂, 中村誠司, 石橋浩晃, 白砂兼光
  • Journal Title: 日本口腔外科学会雑誌 55(6) Pages: 305-309
  • NAID: 10027090653
• [Journal Article] 非接触型三次元計測装置を用いた下顎後方移動術による顔面軟組織の三次元的形状変化の解析 (2009)
  • Author(s): 角町鎮男, 蔵原慎一, 佐々木匡理, 他6名
  • Journal Title: 日本口腔科学会雑誌 58(1) Pages: 11-18
• [Journal Article] Feasible technique for the prediction of lymph node involvement in squamous cell carcinoma of the tongue by nuclear morphometric analysis. (2009)
  • Author(s): Karino M, Ishibashi H, Fujihara S, Watanabe M, Ichiba Y. Nariai Y Kondo S, Sekine J
  • Journal Title: International Journal of Oral & Maxillofacial Surgery, proceedings of the 19th International Conference on Oral and Maxillofacial Surgery 38(5) Pages: 426-426
• [Journal Article] Feasible technique for the prediction of lymph node involvement in squamous cell carcinoma of the tongue by nuclear morphometric analysis. (2009)
  • Author(s): Karino M, Ishibashi H, Fujiwara S, Watanabe M, Ichiba Y, Watanabe M, Ichiba Y, Nariai Y, Kondo S, Sekine J
  • Journal Title: The International College of Surgeons, The 55th Annual Congress of the Japan Section, Proceedings 36
• [Journal Article] Feasibility of implant supported fixed prostheses in oral tumor patients (2009)
  • Author(s): Nariai Y, Kondo S, Ishibashi H, Tsunematsu K, Asahina I, Sano K, Sekine J
  • Journal Title: 68th Annual Meeting of the Japanese Cancer Association, Proceedings 351
• [Journal Article] Autocrine loop between vascular endothelial growth factor(VEGF)-C and VEGF Receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells (2009)
  • Author(s): Matsuura M, Ishibashi H, et.al.
  • Journal Title: Am J Pathology 175(4) Pages: 1709-1721
  • Peer Reviewed
• [Journal Article] Management of tongue squamous cell carcinoma in expectant patients : Report of two Cases (2009)
  • Author(s): Kondo S, Ishibashi H, et al.
  • Journal Title: Asian J Oral Maxillofac Surg 21(2) Pages: 142-148
  • Peer Reviewed
• [Journal Article] Study on feasibility of cervical lymph node metastases in squamous cell carcinoma of the tongue evaluated by morphometric analyses. (2008)
  • Author(s): Karino M, Ishibashi H, Nariai Y, Kondo S, Sekine J
  • Journal Title: PROCEEDINGS 12th International Congress on Oral Cancer in conjunction with 24th International College for Maxillo-Facial-Surgery Pages: 89-90
• [Journal Article] Symposium 1: Surgical conference Case 1; A case of huge ameloblastoma manifested in the mandible (2008)
  • Author(s): Nariai Y, Nakamura M, Maruyama R, Ishibashi H, Sekine J
  • Journal Title: Oral Medicine & Pathology 13(1) Pages: 29-29
• [Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is essential mechamnism of the neu (2008)
  • Author(s): Murakami Y, Ikeda Y, Onimaru M, e
  • Journal Title: Am J Pathol 173(5) Pages: 1326-38
  • Peer Reviewed
• [Journal Article] Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation b〓 (2008)
  • Author(s): Fujii T, Onimaru M, et al
  • Journal Title: Am J Physiol Heart Circ Physiol 294(6) Pages: 2785-91
  • Peer Reviewed
• [Journal Article] VEGF function for upregulation of endogenous PIGF expression during FGF-2-mediated therapeu (2008)
  • Author(s): Fujii T, Yonemitsu Y, Onimaru M et
  • Journal Title: Atheroscrelosis Feb(5)(E Pub)
  • Peer Reviewed
• [Journal Article] VEGF function for upregulation of endogenous PIGF expression during FGF-2-mediated therapeutic angiogenesis (2008)
  • Author(s): Fujii T, Yonemitsu Y, Onimaru M, ら
  • Journal Title: Atherosclerosis Feb5(Epub ahead of print)
  • Peer Reviewed
• [Presentation] 口腔癌の低酸素に依存する血管新生抑制療法の研究 (2007)
  • Author(s): 中川久子, 石橋浩晃
  • Organizer: 第52回日本口腔外科学会総会
  • Place of Presentation: 神戸
• [Remarks] ホームページ
  • URL: http://www.hosp.kyushu-u.ac.jp/shinryo/dent/08/index.html
• [Remarks]
  • URL: http://www.med.shimane-u.ac.jp/oral/index.html