The role of Fc receptor genes in regulation of signal expression associated with susceptibility to periodontitis

• Project/Area Number: 19592383
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Niigata University
• Principal Investigator: KOBAYASHI Tetsuo Niigata University, 医歯学総合病院, 准教授 (00215344)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Kouji 新潟大学, 医歯学総合病院, 助教 (00397142)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯周炎 / 感受性 / 遺伝子 / Fcレセプター / サイトカイン / プロテオーム / リスク遺伝子 / 機能解析 / プロテオーム解析

Research Abstract

本研究では、歯周病のなりやすさ(感受性)に関わる遺伝子として、白血球機能を担う遺伝子(Fcレセプター遺伝子)に注目し、その遺伝子タイプにより歯周病の感受性が異なるメカニズムの解明を目的とした。解析の結果、Fcレセプター遺伝子のタイプで歯周病原細菌に対する免疫反応(抗体)、炎症調節物質(サイトカイン)のでき方、ならびに、白血球で作られるタンパク質が異なり、これらの違いが結果として、歯周病に対する感受性の個人差に結びつく可能性を示した。

Research Products

• [Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults. (2010)
  • Author(s): Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
  • Journal Title: J. Periodontol (in press)
  • Peer Reviewed
• [Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults (2010)
  • Author(s): Tetsuo Kobayashi
  • Journal Title: Journal of Periodontology (印刷中)
  • Peer Reviewed
• [Journal Article] Genetic risk factors for periodontitis in a Japanese population (2009)
  • Author(s): Kobayashi T, Nagata T, Murakami S, Takashiba S, Kurihara H, Izumi Y, Numabe Y, Watanabe H, Kataoka M, Nagai A, Hayashi J, Ohyama H, Okamatsu Y, Inagaki Y, Tai H, Yoshie H
  • Journal Title: J Dent Res 88(12) Pages: 1137-1141
  • Peer Reviewed
• [Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults (2009)
  • Author(s): Kobayashi T, Murasawa A, Ito S, Yamamoto K, Komatsu Y, Abe A, Sumida T, Yoshie H
  • Journal Title: J. Periodontol 80(5) Pages: 792-799
  • Peer Reviewed
• [Journal Article] Mannose binding lectin gene polymorphism and the severity of chronic periodontitis (2009)
  • Author(s): Tsutsumi A, Kobayashi T, Ito S, Goto D, Matsumoto I, Yoshie H, Sumida T
  • Journal Title: Jpn. J. Clin. Immunol 32(1) Pages: 48-52
  • NAID: 10024961926
  • Peer Reviewed
• [Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults (2009)
  • Author(s): Tetsuo Kobayashi
  • Journal Title: Journal of Periodontology 80(5) Pages: 792-799
  • Peer Reviewed
• [Journal Article] Genetic risk factors for periodontitis in a Japanese population (2009)
  • Author(s): Tetsuo Kobayashi
  • Journal Title: Journal of Dental Research 88(12) Pages: 1137-1141
  • Peer Reviewed
• [Journal Article] Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults (2009)
  • Author(s): Tetsuo Kobayashi
  • Journal Title: Journal of Periodontology (印刷中)
  • Peer Reviewed
• [Journal Article] Lower antibody response to Porphyromonas gingivalis associated with immunoglobulin G Fcgamma receptor IIB polymorphism (2008)
  • Author(s): Honma Y, Sugita N, Kobayashi T, Abiko Y, Yoshie H
  • Journal Title: J Periodotnt Res 43(6) Pages: 706-711
  • Peer Reviewed
• [Journal Article] Association of interleukin-1 receptor anatagonist +2018 gene polymorphism with Japanese chronic periodontitis patients using a novel genotyping method (2008)
  • Author(s): Komatsu Y, Galicia JC, Kobayashi T, Yamazaki K, Yoshie H
  • Journal Title: Int. J. Immunogenet 35(2) Pages: 165-170
  • Peer Reviewed
• [Journal Article] Lower antibody response to Porphyromonas gingivalis associated with FcyRIIb polymorphism (2008)
  • Author(s): Yuko Honma
  • Journal Title: Journal of Periodontal Research (印刷中)
  • Peer Reviewed
• [Journal Article] The interleukin-1 and Fcgamma receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis (2007)
  • Author(s): Kobayashi T, Ito S, Kuroda T, Yamamoto K, Sugita N, Narita I, Sumida T, Gejyo F, Yoshie H
  • Journal Title: J. Periodontol 78(12 Pages: 2311-2318
  • Peer Reviewed
• [Journal Article] The FcgammaRIIa polymorphism influences production of interleukin-1 by mononuclear cells (2007)
  • Author(s): Yamamoto K, Kobayashi T, Sugita N, TaiH, Yoshie H
  • Journal Title: Int. J. Immunogene 34(5) Pages: 369-372
  • Peer Reviewed
• [Journal Article] The FcγRIIa polymorphism influences production of interleukin-1 by mononuclear cells (2007)
  • Author(s): Kouji Yamamoto
  • Journal Title: International Journal of Immunogenetics 31 Pages: 369-372
  • Peer Reviewed
• [Journal Article] The interleukin-1 and Fcγ receptor gene polymorphisms in Japanese patients with rheumatoid arthritis and periodontitis (2007)
  • Author(s): Tetsuo Kobayashi
  • Journal Title: Journal of Periodontology 78 Pages: 2311-2318
  • Peer Reviewed
• [Presentation] 関節リウマチ活動度と歯周疾患重症度との関連性 (2009)
  • Author(s): 小林哲夫
  • Organizer: 日本歯科保存学会2009年度秋季学術大会(第131回)
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-30
• [Presentation] 歯周炎感受性に関わる好中球FcgammaRIIIb遺伝子多型のプロテオーム解析 (2009)
  • Author(s): 横山智子
  • Organizer: 第52回秋季日本歯周病学会学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2009-10-11
• [Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型 (2009)
  • Author(s): 小林哲夫
  • Organizer: 第52回春季日本歯周病学会学術大会
  • Place of Presentation: 岡山.
  • Year and Date: 2009-05-15
• [Presentation] 関節リウマチおよび歯周炎感受性に関わるサイトカイン遺伝子多型 (2009)
  • Author(s): 小林哲夫
  • Organizer: 第52回春季日本歯周病学会学術大会
  • Place of Presentation: 岡山市岡山コンベンションセンター
  • Year and Date: 2009-05-15
• [Presentation] Gene Polymorphisms in Rheumatoid Arthritis and Periodontitis in Japanese (2008)
  • Author(s): Kobayashi T
  • Organizer: The 4th Pan European Federation of International Association for Dental Research
  • Place of Presentation: London
  • Year and Date: 2008-09-11
• [Presentation] Gene polymorphisms in rheumatoid arthritis and periodontitis in Japanese (2008)
  • Author(s): Tetsuo Kobayashi
  • Organizer: The 4th Pan European Federation of International Association for Dental Research
  • Place of Presentation: London, UK
  • Year and Date: 2008-09-11
• [Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis (2007)
  • Author(s): Kobayashi T
  • Organizer: The 93rd. Annual Meeting of the Aerican Academy of Periodontology
  • Place of Presentation: Washington DC
  • Year and Date: 2007-10-29
• [Presentation] Functional gene polymorphisms in rheumatoid arthritis and periodontitis (2007)
  • Author(s): Tetsuo Kobayashi
  • Organizer: The 93rd. Annual Meeting of the American Academy of Periodontology
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2007-10-29
• [Book] Preventive Periodontology臨床を支えるサイエンスを知る、唾液検査を活用する、生活習慣病を予防する (2007)
  • Author(s): 小林哲夫、吉江弘正
  • Publisher: 医歯薬出版