Fibulin upregulated by mechanical strain controls the formation of oxytalan fibers.
Project/Area Number |
19592391
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Fukuoka Dental College |
Principal Investigator |
TSURUGA Eichi Fukuoka Dental College, 歯学部, 准教授 (30295901)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 歯根膜 / オキシタラン線維 / 弾性系線維 / 細胞外基質 / 線維芽細胞 / 細胞・組織 / 歯学 |
Research Abstract |
Human periodontal ligaments (PDL) contain oxytalan fibers. However, the behavior of oxytalan fibers is unclear. We hypothesized that the fibulin-5 contributes to oxytalan fiber formation under mechanical strain. Fibrillin-1 contains the RGD motif. We subjected PDL fibroblasts to stretching strain. The oxytalan fibers coalesced by stretching. Fibulin-5 colocalizes on oxytalan fibers. Stretching increased fibulin-5 gene expression. The fibulin-5 suppression inhibited the coalescence of oxytalan fibers. The treatment with the integrin αvβ3 antagonist inhibited fibrillin-1 deposition. These results suggest that fibulin-5 may control the formation of oxytalan fibers bundles in PDL.
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Report
(4 results)
Research Products
(12 results)