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The role of dendritic cells in regulation of memory CD8 T cell differentiation

Research Project

Project/Area Number 19599007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

IWAI Yoshiko  Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (90362467)

Research Collaborator STEINMAN Ralph M.  Rockefeller University, Professor
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords細胞 / 免疫学的記憶 / 樹状細胞 / T細胞
Research Abstract

免疫学的記憶とは過去に出会った抗原に対してより早く、より大きな免疫応答が起こる現象でワクチンの基礎となる。記憶T細胞の特徴としてはnaive なT 細胞よりも早く増殖することが知られているが、そのメカニズムについてはまったく知られていない。本研究では記憶CD8T 細胞から分泌されるIFN-と樹状細胞から分泌されるIL-18が相互に刺激しあってシグナルループを形成し、記憶T細胞の増殖を加速する役割を果たしていることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (4 results)

All 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] AnIFN-γ-IL-18signaling loop acceleratesmemory CD8+ Tcell proliferation2008

    • Author(s)
      Yoshiko Iwai, Hiroaki Hemmi, Olga Mizenina, Shoko Kuroda, Koji Suda,and Ralph M. Steinman
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective delivery ofbeta cell antigen to dendritic cells invivo leads to deletion and tolerance ofautoreactive CD8+ T cells in NOD mice2008

    • Author(s)
      Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP
    • Journal Title

      Proc Natl Acad Sci USA 105(17)

      Pages: 6374-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An IFN-γ-IL-18 signaling loop accelerates memory CD8+ T cell proliferation2008

    • Author(s)
      Yoshiko Iwai, Hiroaki Hemmi, Olga Mizenina, Shoko Kuroda, Koji Suda, Ralph M. Steinman
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Delivery of β Cell Antigen to Dendritic Cells In Vivo Leads to Deletion and Tolerance of Autoreactive CD8+T Cells in NOD Mice2008

    • Author(s)
      Arunika Mukhopadhaya, Tadashi Hanafusa, Irene Jarchum, Yi-Guang Chen, Yoshiko Iwai, David Serreze, Ralph Steinman, Kristin Tarbell, Teresa DiLorenzo
    • Journal Title

      PNAS (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed

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Published: 2007-04-01   Modified: 2016-04-21  

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