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Research of γδ T cells in Sjogren, s syndrome model mouse

Research Project

Project/Area Number 19599009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKanazawa University

Principal Investigator

UEDA Ikuko  Kanazawa University, 医学系, 助教 (80452100)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords皮膚生理学 / シェーグレン症候群 / γδT 細胞 / Id3- / - / γδT細胞
Research Abstract

Id3-/-マウスにおいてγδT細胞の増殖の異常が出現する機序と、シェーグレン症候群様症状発症との関連の検証を行った。γδT細胞の増加は胸腺におけるT 細胞発生の段階のうちβ鎖再編成の進んだ段階でおこっていた。γδT細胞の多くがVγ1陽性でレパトアの異常があり、刺激によるIFN-γ産生は亢進していた。さらにId3-/-γδT細胞を野生型マウスに移入したところ、唾液腺への細胞浸潤を認め、シェーグレン症候群発症への関与が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] Id3 restricts the developmental potential of gd lineage during thymopoiesis2009

    • Author(s)
      Ikuko Ueda-Hayakawa, Josh Malios, and Yuan Zhuang
    • Journal Title

      J Immunol 182

      Pages: 5306-5316

    • Related Report
      2008 Final Research Report
  • [Journal Article] Id3 restricts the developmental potential in gd lineage during thymopoiesis2009

    • Author(s)
      Ikuko Ueda-Hayakawa, Josh Mahlios, Yuan Zhuang
    • Journal Title

      Journal of Immunology 182(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis2008

    • Author(s)
      Yasuhito Hamaguchi, Minoru Hasegawa, Manabu Fujimoto, Ikuko Hayakawa(他9名)
    • Journal Title

      Br J Dermatol 158

      Pages: 487-95

    • Related Report
      2008 Final Research Report
  • [Journal Article] Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies2007

    • Author(s)
      Takamasa Wayaku, Minoru Hasegawa, Kenzo Kaji, Ikuko Hayakawa(他11名)
    • Journal Title

      28

      Pages: 113-119

    • Related Report
      2008 Final Research Report
  • [Journal Article] B-lymphocyte depletion ameliorates Sjogren syndrome in Id3 knockout mice2007

    • Author(s)
      Ikuko Hayakawa, Thomas F. Tedder, Yuan Zhuang
    • Journal Title

      122

      Pages: 73-9

    • Related Report
      2008 Final Research Report
  • [Journal Article] Reduced red blood cell velocity in nailfold capillaries as a sensitive and specific indicator of microcirculation injury in systemic sclerosis

    • Author(s)
      Mugii Naoki, Minoru Hasegawa, Yasuhito Hamaguchi, Ikuko Ueda-Hayakawa(他10 名)
    • Journal Title

      Rheumatology in press

    • Related Report
      2008 Final Research Report
  • [Presentation] Id3 is required to suppress γδ lineage development post TCRβ gene rearrangement2007

    • Author(s)
      Ikuko Hayakawa and Yuan Zhuang
    • Organizer
      第37 回日本免疫学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Id3 is required to suppress Yδ lineage development post TCRβ gene rearrangement2007

    • Author(s)
      早川郁子
    • Organizer
      第37回日本免疫学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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