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Stimulation of graft remodel ing to accelerate returning period to sport activity

Research Project

Project/Area Number 19599014
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKobe University

Principal Investigator

KUBO Seiji  Kobe University, 医学部附属病院, 医員 (30452494)

Co-Investigator(Kenkyū-buntansha) KURODA Ryosuke  神戸大学, 医学部附属病院, 講師 (80379362)
KUROSAKA Masahiro  神戸大学, 大学院・医学研究科, 教授 (70170115)
FUJIOKA Hiroyuki  神戸大学, 大学院・医学研究科, 講師 (10252777)
MIWA Masahiko  神戸大学, 医学部附属病院, 助教 (20397805)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,750,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords前十字靭帯損傷 / 移植腱の成熟 / 幹細胞 / 前十字靭帯再建術 / 移植腱成熟 / 前十字靱帯再建術
Research Abstract

前十字靭帯移植腱の再生を促進する手法に付きその有効なcell sourseとしての関節内血腫、断裂靭帯断端、などから細胞を採取し、それぞれの細胞腫について、増殖能力、分化能力の比較を行った。有用な細胞腫と思われたCD34陽性細胞の局所細胞移植、成長因子としてG-CSFの局所投与に関する実験を動物実験で行い、その効果を組織学的、生体工学的に解析した所、いずれにおいてもその有用性を示す結果を得た。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report

Research Products

(4 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Enhancement of tendon-bone osteointegration of anterior cruciate ligament graft using granulocyte colony-stimulating factor2008

    • Author(s)
      Sasaki K, Kuroda R, Ishida K, Kubo S, Matsumoto T, Mifune Y, Kinoshita K, Tei K, Akisu e T, Tabata Y, Kurosaka M
    • Journal Title

      Am J Sports Med. 36(8)

      Pages: 1519-1527

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administrations of peripheral blood CD34-positive cells contribute to medial collateral ligament healing via vasculogenesis2008

    • Author(s)
      Tei K, Matsumoto T, Mifune Y, Ishida K, Sasaki K, Shoji T, Kubo S, Kawamoto A, Asahara T, Kurosaka M, Kuroda R.
    • Journal Title

      Stew Cells 26(3)

      Pages: 819-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 膝前十字靭帯由来血管幹細胞の分離と同定2008

    • Author(s)
      松本知之, 黒田良祐, 大沢亜紀, 久保晴司, Johnny Huardm Freddie H. Fu, 黒坂昌弘
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      奈良
    • Related Report
      2008 Final Research Report
  • [Presentation] Peripheral blood CD34-positive cells contribute to ligament healing2008

    • Author(s)
      Tei K, Matsumoto T, Mifune Y, Ishida K, Sasaki K, FujitaN, Kubo S, Kurosaka M, Kuroda R
    • Organizer
      54th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

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