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The mechanism and its inter-individual variability of the Blood-Brain Barrier penetration of anti-influenza drug, oseltamivir

Research Project

Project/Area Number 19599023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTakasaki University of Health and Welfare

Principal Investigator

MORIMOTO Kaori  Takasaki University of Health and Welfare, 薬学部, 講師 (90401009)

Co-Investigator(Kenkyū-buntansha) OGIHARA Takuo  高崎健康福祉大学, 薬学部, 教授 (80448886)
玉井 郁巳  金沢大学, 自然科学研究科, 教授 (20155237)
Co-Investigator(Renkei-kenkyūsha) TAMAI Ikumi  金沢大学, 自然科学研究科, 教授 (20155237)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,790,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywordsトランスポーター / オセルタミビル / 血液脳関門 / P-糖タンパク質 / 消化管吸収 / 相互作用 / PEPT1 / P-糖蛋白質
Research Abstract

オセルタミビルの体内動態の変動要因として、血液脳関門でオセルタミビルの排出輸送に関与するP-糖タンパク質と、消化管吸収に関与するペプチドトランスポーター、PEPT1を見出した。オセルタミビルの体内動態(脳内濃度)の個人差には、これらのトランスポーターの機能変化を伴なう遺伝子多型、発現量の年齢差および併用する薬物や食物による相互作用等が関与する可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (14 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009

    • Author(s)
      Takuo Ogihara, et al.
    • Journal Title

      Drug Metab Dispos (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein.2008

    • Author(s)
      Morimoto K, Nakakariya M, Shirasaka Y, Kakinuma C, Fujita T, Tamai I, Ogihara T.
    • Journal Title

      Drug Metab Dispos 36

      Pages: 6-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oseltamivir (Tamiful) efflux transport at the Blood-Brain Barrier by P-glycoprotein2008

    • Author(s)
      Kaori Morimoto, et. al.
    • Journal Title

      Drug Metabolism and Disposition 36

      Pages: 6-9

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.

    • Author(s)
      Ogihara T, Kano T, Wagatsuma T, Wada S, Yabuuchi H, Enomoto S, Morimoto K, Shirasaka Y, Kobayashi S, Tamai I.
    • Journal Title

      Drug Metab Dispos in press

      Pages: 0-0

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] オセルタミビルのPEPT1基質認識性と消化管吸収における食事由来ペプチドの影響2009

    • Author(s)
      我妻瑶恵ら
    • Organizer
      日本薬剤学会第24年回
    • Place of Presentation
      静岡
    • Year and Date
      2009-05-23
    • Related Report
      2008 Final Research Report
  • [Presentation] オセルタミビルのPEPT1基質認識性と消化管吸収における食事由来ペプチドの影響2009

    • Author(s)
      我妻 瑶恵 ら
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      静岡コンベンションツアーセンター(静岡)(発表確定)
    • Year and Date
      2009-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 食事由来ペプチドがヒトペプチドトランスポーターPEPT1に基質認識される薬物の消化管吸収に及ぼす影響2009

    • Author(s)
      小林彰子ら
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Oseltamivir (Tamiflu^<TM>) is a substrate of PEPT1.2009

    • Author(s)
      Ogihara T, et al.
    • Organizer
      3rd Asia Pacific Regional ISSX Meeting
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-05-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 食事由来ペプチドがヒトペプチドトランスポーターPEPT1に基質認識される薬物の消化管吸収に与える影響2009

    • Author(s)
      小林 彰子 ら
    • Organizer
      第63回日本栄養・食糧学会
    • Place of Presentation
      長崎ブリックホール(長崎)(発表確定)
    • Year and Date
      2009-05-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oseltamivir (Tamiflu^<TM>)is a substrate of PEPT12009

    • Author(s)
      Takuo Ogihara, et al.
    • Organizer
      3rd Asian Pacific Regional ISSX Meeting
    • Place of Presentation
      Bangkok, Thailand(発表確定)
    • Year and Date
      2009-05-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009

    • Author(s)
      荻原琢男ら
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である2009

    • Author(s)
      荻原 琢男 ら
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Controlled Brain Exposure of Oseltamivir by Drug Transporters. 2^<nd> Asia Pacific Regional ISSX Meeting.2008

    • Author(s)
      Morimoto K, et al.
    • Organizer
      2^<nd> Asia Pacific Regional ISSX Meeting
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Controlled Brain Exposure of Oseltamivir by Drug Transporters2008

    • Author(s)
      Kaori Morimoto, et al.
    • Organizer
      2^<nd> Asian Pacific Regional ISSX Meeting
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2008-05-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-glycoprotein2007

    • Author(s)
      Morimoto K, et al.
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Oseltamivir (Tamiful) efflux transport at the Blood-Brain Barrier by P-glycoprotein2007

    • Author(s)
      Kaori Morimoto, et. al.
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] P糖タンパク質による抗インフルエンザウイルス薬オセルタミビルの中枢移行性制御2007

    • Author(s)
      白坂義之ら
    • Organizer
      第1回トランスポーター研究会東北支部会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-25
    • Related Report
      2008 Final Research Report
  • [Presentation] P糖タンパク質による抗インフルエンザ薬オセルタミビルの中枢移行性制御2007

    • Author(s)
      白坂 善之 ら
    • Organizer
      第1回トランスポーター研究会東北支部会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-25
    • Related Report
      2007 Annual Research Report
  • [Book] 創薬支援研究の展望2008

    • Author(s)
      荻原琢男、森本かおり、玉井郁巳
    • Publisher
      株式会社シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Book] トランスポーター科学最前線2008

    • Author(s)
      荻原琢男、森本かおり
    • Publisher
      京都廣川書店
    • Related Report
      2008 Final Research Report
  • [Book] 創薬支援研究の展望2008

    • Author(s)
      荻原 琢男 ら
    • Publisher
      株式会社シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Book] トランスポーター科学最前線2008

    • Author(s)
      荻原 琢男 ら
    • Publisher
      京都廣川書店
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.takasaki-u.ac.jp/dept/yaku/labo/news/details.htm

    • Related Report
      2008 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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