• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The roles of neuronal calcium channels on the physiological functions of opioid analgesics

Research Project

Project/Area Number 19603002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KURIHARA Takashi  Tokyo Medical and Dental University, 医歯学総合研究科, 助教 (60282745)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsオピオイド / モルヒネ / 電位依存性カルシウムチャネル / 鎮痛 / 鎮痛耐性 / cDNAマイクロアレイ / 消化管運動抑制
Research Abstract

Opioids like morphine exert strong analgesic effects and have essential therapeutic values to eliminate intractable pain. Thus opioid drugs became indispensable medicine to improve the quality of life of pain patient. However, opioid tolerance and dependence are difficult problems associated with the opioid therapy and opioid addiction. Unfortunately, efficient method to prevent analgesic tolerance based on the underlying mechanism has not been developed yet. We have shown previously that mice lacking R-type voltage-dependent Ca^<2+> channel showed enhanced morphine analgesia but also showed resistance to morphine tolerance. To identify molecules responsible for the altered analgesic responses, we have conducted cDNA microarray analysis using brainstem tissues and found several candidate genes involved in the altered morphine responses. The results from several pharmacological, biochemical and immunohistochemical experiments suggested the existence of new signal transduction mechanisms in the development of morphine tolerance in the brainstem area. We have also indicated that it might be possible to induce tolerance against morphine-evoked constipation by manipulating pharmacologically the similar signal transduction existed in the intestine.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (16 results)

All 2009 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results) Remarks (4 results)

  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice2009

    • Author(s)
      Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S., Tanabe, T.
    • Journal Title

      J.Pharmacol.Sci. 110

      Pages: 55-63

    • NAID

      10025736602

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S, Tanabe, T.
    • Journal Title

      Mol.Pain 5

      Pages: 74-74

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.2009

    • Author(s)
      Kondo, D., Saegusa, H., Yabe, R., Takasaki, I., Kurihara, T., Zong, S., Tanabe, T.
    • Journal Title

      Journal of Pharmacological Sciences 110

      Pages: 55-63

    • NAID

      10025736602

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain.2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S., Tanabe, T.
    • Journal Title

      Molecular Pain 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain.

    • Author(s)
      D. Kondo, H. Saegusa, R. Yabe, I. Takasaki, T. Kurihara, S. Zong & T. Tanabe
    • Journal Title

      Journal of Pharmacological Sciences (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Co-administration of ATP attenuates peripheral type benzodiazepine receptor antagonist-induced antinociception of neuropathic pain2008

    • Author(s)
      Tanabe, T., et. al.
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Co-administration of ATP attenuates peripheral type benzodiazepine receptor antagonist-induced antinociception of neuropathic pain.2008

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa, S. Zong
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain through the activation of microglia2008

    • Author(s)
      Tanabe, T., et. al.
    • Organizer
      Third Asian Pain symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain through the activation of microglia.2008

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa, S. Zong
    • Organizer
      Third Asian Pain symposium
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain2007

    • Author(s)
      Tanabe, T., et. al.
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego CA, USA
    • Year and Date
      2007-11-07
    • Related Report
      2009 Final Research Report
  • [Presentation] Enhanced expression of peripheral-type benzodiazepine receptor induces neuropathic pain.2007

    • Author(s)
      T. Tanabe, D. Kondo, R. Yabe, I. Takasaki, T. Kurihara, H. Saegusa & S. Zong
    • Organizer
      The 37th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego CA, USA
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Is up-regulation of neurosteroid synthesis important for the maintenance of neuropathic pain?2007

    • Author(s)
      Tanabe, T., et. al.
    • Organizer
      Second International Congress on Neuropathic Pain
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-06-09
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/med/mphm/Yakuri.HTM

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi