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Roles of plastic changes in glutamate transporter function within the spinal cord in neuropathic pain

Research Project

Project/Area Number 19603010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pain science
Research InstitutionSapporo Medical University

Principal Investigator

YAMAUCHI Masanori  Sapporo Medical University, 医学部, 講師 (00404723)

Co-Investigator(Kenkyū-buntansha) 南 雅文  北海道大学, 大学院・薬学研究院, 教授 (20243040)
Co-Investigator(Renkei-kenkyūsha) MINAMI Masabumi  北海道大学, 大学院・薬学研究院, 教授 (20243040)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsグルタミン酸トランスポーター / 一酸化窒素 / 神経因性疼痛 / 酸化ストレス / GLT-1 / GLAST / アストロサイト / 疼痛 / 過酸化水素水 / ニトロシル化
Research Abstract

グルタミン酸トランスポーター酸化的修飾の神経因性疼痛への関与を明らかにすることを目的として研究を行った。グルタミン酸トランスポーター阻害薬のラット髄腔内投与は、熱性痛覚過敏および機械的アロディニアを惹起した。グルタミン酸トランスポーターの酸化的修飾による活性変化を検討したところ、グルタミン酸トランスポーターGLT-1が酸化的修飾されることが示されたが、酸化的修飾による取り込み活性変化は認められなかった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (4 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery2008

    • Author(s)
      Yamauchi M, Asano M, Watanabe M, Iwasaki S, Furuse S, Namiki A
    • Journal Title

      Anesth Analg 107

      Pages: 1041-1044

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous low dose ketamine improves the analgesic effects of fentanyl patients-controlled analgesia after cervical spine surgery2008

    • Author(s)
      Yamauchi M
    • Journal Title

      Anesth Analg 107

      Pages: 1041-1044

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Emergency percutaneous dilational tracheostomy with transtracheal jet ventilation2008

    • Author(s)
      Seki S, Sugino S, Yamauchi M, Yamakage M, Namiki A
    • Organizer
      The annual meeting of the American society of anesthesiologists
    • Place of Presentation
      米国・オーランド
    • Related Report
      2008 Final Research Report
  • [Presentation] Emergency percutaneous dilational tracheostomy with transtracheal jet ventilation2008

    • Author(s)
      Seki S
    • Organizer
      The annual meeting of the American society of anesthesiologists
    • Place of Presentation
      Orland U. S. A
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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